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Nathan B. Wikle

Publications and source records attributed to Nathan B. Wikle.

3 recordsLinked to original sources

Calibrated Bayesian Inference for Stochastic Intervention Effects

Causal inference increasingly extends beyond classical causal effects defined by deterministic treatment assignments, such as the average treatment effect, to stochastic intervention effects that can weaken positivity requirements and offer greater policy relevance. Nonparametric Bayesian models are attractive for estimating these effects due to their flexibility and inherent uncertainty propagation, but this posterior uncertainty need not be well calibrated for the causal effect of interest. We develop a simple post-processing correction that can be applied to posterior samples without changing the prior or fitting algorithm. We prove that, for a broad class of stochastic interventions, the corrected posterior yields asymptotically efficient inference and credible intervals with asymptotically valid frequentist coverage; formally, it satisfies a semiparametric Bernstein-von Mises theorem. The theory covers interventions specified independently of the observed treatment process, as well as interventions that modify it, including incremental propensity score interventions and a new power-tilt intervention. A central contribution is new theory for SoftBART, including conditions under which this flexible tree-based Bayesian model supports calibrated Bayesian inference for stochastic intervention effects. In simulations, the correction reduces bias and improves coverage relative to the uncorrected Bayesian analysis while remaining competitive with frequentist alternatives. We illustrate the method by estimating how expected LDL cholesterol would change under hypothetical increases or decreases in the odds of receiving statin therapy.

stat.ME

Causal health impacts of power plant emission controls under modeled and uncertain physical process interference

Causal inference with spatial environmental data is often challenging due to the presence of interference: outcomes for observational units depend on some combination of local and non-local treatment. This is especially relevant when estimating the effect of power plant emissions controls on population health, as pollution exposure is dictated by (i) the location of point-source emissions, as well as (ii) the transport of pollutants across space via dynamic physical-chemical processes. In this work, we estimate the effectiveness of air quality interventions at coal-fired power plants in reducing two adverse health outcomes in Texas in 2016: pediatric asthma ED visits and Medicare all-cause mortality. We develop methods for causal inference with interference when the underlying network structure is not known with certainty and instead must be estimated from ancillary data. Notably, uncertainty in the interference structure is propagated to the resulting causal effect estimates. We offer a Bayesian, spatial mechanistic model for the interference mapping which we combine with a flexible non-parametric outcome model to marginalize estimates of causal effects over uncertainty in the structure of interference. Our analysis finds some evidence that emissions controls at upwind power plants reduce asthma ED visits and all-cause mortality, however accounting for uncertainty in the interference renders the results largely inconclusive.

stat.AP

A Mechanistic Model of Annual Sulfate Concentrations in the United States

We develop a mechanistic model to analyze the impact of sulfur dioxide emissions from coal-fired power plants on average sulfate concentrations in the central United States. A multivariate Ornstein-Uhlenbeck (OU) process is used to approximate the dynamics of the underlying space-time chemical transport process, and its distributional properties are leveraged to specify novel probability models for spatial data (i.e., spatially-referenced data with no temporal replication) that are viewed as either a snapshot or a time-averaged observation of the OU process. Air pollution transport dynamics determine the mean and covariance structure of our atmospheric sulfate model, allowing us to infer which process dynamics are driving observed air pollution concentrations. We use these inferred dynamics to assess the regulatory impact of flue-gas desulfurization (FGD) technologies on human exposure to sulfate aerosols.

stat.ME