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Nazir Lone

Publications and source records attributed to Nazir Lone.

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Bayesian Supervised Causal Clustering

Finding patient subgroups with similar characteristics is crucial for personalized decision-making in various disciplines such as healthcare and policy evaluation. While most existing approaches rely on unsupervised clustering methods, there is a growing trend toward using supervised clustering methods that identify operationalizable subgroups in the context of a specific outcome of interest. We propose Bayesian Supervised Causal Clustering (BSCC), with treatment effect as outcome to guide the clustering process. BSCC identifies homogenous subgroups of individuals who are similar in their covariate profiles as well as their treatment effects. We evaluate BSCC on simulated datasets as well as real-world dataset from the third International Stroke Trial to assess the practical usefulness of the framework.

stat.ML

What do we mean when we say we are clustering multimorbidity?

Clustering multimorbidity has been a global research priority in recent years. Existing studies usually identify these clusters using one of several popular clustering methods and then explore various characteristics of these clusters, e.g., their genetic underpinning or their sociodemographic drivers, as downstream analysis. These studies make several choices during clustering that are often not explicitly acknowledged in the literature, e.g., whether they are clustering conditions or clustering individuals, and thus, they lead to different clustering solutions. We observe that, in general, clustering multimorbidity might mean different things in different studies, and argue that making these choices more explicit and, more importantly, letting the downstream analysis, or the purpose of identifying multimorbidity clusters, guide these choices, might lead to more transparent and operationalizable multimorbidity clusters. In this study, we discuss various purposes of identifying multimorbidity clusters and build a case for how different purposes can justify the different choices in data and methods.

stat.AP