arXiv subjects

Neerja Aggarwal

Publications and source records attributed to Neerja Aggarwal.

3 recordsLinked to original sources

arXiv2026

Spectral DiffuserScope: a compact snapshot hyperspectral microscope

Hyperspectral fluorescence microscopy enables important biological and clinical applications, but conventional systems are bulky or require scanning, limiting temporal resolution and throughput. We introduce a computational snapshot hyperspectral microscope that uses compressed sensing to achieve higher spatial-spectral resolution than traditional snapshot systems. Our device is compact (~15 cm x 6 cm x 6 cm) and easily attaches to standard fluorescence microscopes. We benchmark our system against existing snapshot methods through simulations to evaluate its spatial and spectral performance. Experimental imaging of fluorescent beads, labeled cells, and lanthanide hydrogel beads demonstrates a practical, high-throughput solution for hyperspectral microscopy in biological and clinical applications.

physics.optics↗

arXiv2026

The Need for Neural ISP in the Small-Pixel Era: How Shrinking Pixels Push Optics to the Limit and Neural Restoration Pushes Back

Smartphone telephoto cameras are approaching a "telephoto physics wall": as pixel pitches shrink toward sub-0.5 micron, the optics remain limited by geometric aberrations, leading to diminishing returns on resolution. Traditional Image Signal Processors (ISPs) cannot eliminate these aberrations, because they operate through local, stage-wise processing with no explicit model of the underlying point spread function (PSF). We demonstrate how a learning-based Neural ISP for image restoration, trained on the underlying degradations, inverts what stage-wise pipelines cannot, turning small-pixel designs into a net advantage. We investigate this through a controlled simulation of a representative telephoto module, evaluating five configurations (0.35--0.75 micron pixel pitch). The aperture is scaled proportionally to keep per-pixel SNR and diffraction spot size fixed, thereby isolating geometric aberration and spatial sampling. While the traditional ISP improves only modestly with smaller pixels, the Neural ISP scales substantially: at 0.35 micron} it reaches 745 cycles/mm MTF50 (vertical), a 2.5--3x resolution improvement over the traditional ISP, and LPIPS improves significantly from 0.244 to 0.151 while traditional results stay comparatively flat. In a low-SNR extension (15 dB per-frame bursts at 0.35 micron), a multi-frame Neural ISP recovers performance close to the bright-light single-frame baseline, whereas a multi-frame traditional ISP shows no meaningful improvement -- indicating that traditional pipelines at small pixels are bottlenecked by uncorrected PSF blur rather than by noise. These results point to a design philosophy in which Neural ISPs enable high-resolution telephoto modules by correcting residual optical aberrations rather than requiring increasingly complex optics.

eess.IV↗

arXiv2020

Spectral DiffuserCam: lensless snapshot hyperspectral imaging with a spectral filter array

Hyperspectral imaging is useful for applications ranging from medical diagnostics to agricultural crop monitoring; however, traditional scanning hyperspectral imagers are prohibitively slow and expensive for widespread adoption. Snapshot techniques exist but are often confined to bulky benchtop setups or have low spatio-spectral resolution. In this paper, we propose a novel, compact, and inexpensive computational camera for snapshot hyperspectral imaging. Our system consists of a tiled spectral filter array placed directly on the image sensor and a diffuser placed close to the sensor. Each point in the world maps to a unique pseudorandom pattern on the spectral filter array, which encodes multiplexed spatio-spectral information. By solving a sparsity-constrained inverse problem, we recover the hyperspectral volume with sub-super-pixel resolution. Our hyperspectral imaging framework is flexible and can be designed with contiguous or non-contiguous spectral filters that can be chosen for a given application. We provide theory for system design, demonstrate a prototype device, and present experimental results with high spatio-spectral resolution.

eess.IV↗