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Neha Agarwala

Publications and source records attributed to Neha Agarwala.

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Conic Sparsity: Estimation of Regression Parameters in Closed Convex Polyhedral Cones

Statistical problems often involve linear equality and inequality constraints on model parameters. Direct estimation of parameters restricted to general polyhedral cones, particularly when one is interested in estimating low dimensional features, may be challenging. We use a dual form parameterization to characterize parameter vectors restricted to lower dimensional faces of polyhedral cones and use the characterization to define a notion of 'sparsity' on such cones. We show that the proposed notion agrees with the usual notion of sparsity in the unrestricted case and prove the validity of the proposed definition as a measure of sparsity. The identifiable parameterization of the lower dimensional faces allows a generalization of popular spike-and-slab priors to a closed convex polyhedral cone. The prior measure utilizes the geometry of the cone by defining a Markov random field over the adjacency graph of the extreme rays of the cone. We describe an efficient way of computing the posterior of the parameters in the restricted case. We illustrate the usefulness of the proposed methodology for imposing linear equality and inequality constraints by using wearables data from the National Health and Nutrition Examination Survey (NHANES) actigraph study where the daily average activity profiles of participants exhibit patterns that seem to obey such constraints.

stat.ME

Efficient Integration of Aggregate Data and Individual Patient Data in One-Way Mixed Models

Often both Aggregate Data (AD) studies and Individual Patient Data (IPD) studies are available for specific treatments. Combining these two sources of data could improve the overall meta-analytic estimates of treatment effects. Moreover, often for some studies with AD, the associated IPD maybe available, albeit at some extra effort or cost to the analyst. We propose a method for combining treatment effects across trials when the response is from the exponential family of distribution and hence a generalized linear model structure can be used. We consider the case when treatment effects are fixed and common across studies. Using the proposed combination method, we evaluate the wisdom of choosing AD when IPD is available by studying the relative efficiency of analyzing all IPD studies versus combining various percentages of AD and IPD studies. For many different models design constraints under which the AD estimators are the IPD estimators, and hence fully efficient, are known. For such models we advocate a selection procedure that chooses AD studies over IPD studies in a manner that force least departure from design constraints and hence ensures a fully efficient combined AD and IPD estimator.

stat.ME