arXiv subjects

Nicholas R. Rasmussen

Publications and source records attributed to Nicholas R. Rasmussen.

3 recordsLinked to original sources

arXiv2026

Robust and Clinically Reliable EEG Biomarkers: A Cross Population Framework for Generalizable Parkinson's Disease Detection

Developing robust and clinically reliable EEG biomarkers requires evaluation frameworks that explicitly address cross population generalization in multi site settings such as Parkinsons disease (PD) detection. Models trained under i.i.d. assumptions often capture population specific artifacts rather than disease relevant neural structure, leading to poor generalization across clinical cohorts. EEG further amplifies this challenge due to low signal to noise ratio and heterogeneous acquisition conditions. We propose a population aware evaluation framework to assess the robustness and clinical reliability of EEG biomarkers under distribution shift. Using an n gram expansion strategy, we enumerate all cross population train test configurations across five independent cohorts, resulting in 75 directional evaluations. A nested cross validation design with integrated channel selection ensures prospective biomarker identification without population leakage. Results show that cross population transfer is asymmetric and that both accuracy and biomarker stability improve with increasing training population diversity, achieving up to 94.1% accuracy on held out cohorts. A theoretical analysis based on mixture risk optimization and hypothesis space contraction explains these trends, showing that multi population training promotes population robust representations. This work establishes a principled framework for learning robust, generalizable, and clinically reliable EEG biomarkers for multi site biomedical applications.

cs.LG↗

arXiv2025

Channel Selected Stratified Nested Cross Validation for Clinically Relevant EEG Based Parkinsons Disease Detection

The early detection of Parkinsons disease remains a critical challenge in clinical neuroscience, with electroencephalography offering a noninvasive and scalable pathway toward population level screening. While machine learning has shown promise in this domain, many reported results suffer from methodological flaws, most notably patient level data leakage, inflating performance estimates and limiting clinical translation. To address these modeling pitfalls, we propose a unified evaluation framework grounded in nested cross validation and incorporating three complementary safeguards: (i) patient level stratification to eliminate subject overlap and ensure unbiased generalization, (ii) multi layered windowing to harmonize heterogeneous EEG recordings while preserving temporal dynamics, and (iii) inner loop channel selection to enable principled feature reduction without information leakage. Applied across three independent datasets with a heterogeneous number of channels, a convolutional neural network trained under this framework achieved 80.6% accuracy and demonstrated state of the art performance under held out population block testing, comparable to other methods in the literature. This performance underscores the necessity of nested cross validation as a safeguard against bias and as a principled means of selecting the most relevant information for patient level decisions, providing a reproducible foundation that can extend to other biomedical signal analysis domains.

eess.SP↗

arXiv2025

GetNetUPAM: Ecologically Informed Nested Cross-Validation and Noise-Robust Attention for Marine Bioacoustic Monitoring

Deploying reliable bioacoustic monitoring systems requires models that generalize under high-noise, low-SNR conditions and evaluation protocols that expose deployment-relevant failure modes, gaps largely unaddressed in current UPAM practice. Intrinsic noise, variable propagation, and mixed biological and anthropogenic sources induce distribution shifts that conventional models and single-split evaluations obscure, inflating performance and masking instability. We introduce GetNetUPAM, a hierarchical nested cross-validation framework that uses the nested stage to quantify model stability rather than tune for inflated hold-out scores. By partitioning data into site-year blocks, GetNetUPAM preserves ecological heterogeneity and forces each outer fold to represent a distinct environmental regime, preventing overfitting to localized noise or sensor artifacts. Inner stratified folds measure generalization across the full UPAM signal distribution, enforcing strict separation between model development and the outer held-out deployment condition. Using GetNetUPAM, we evaluate the Adaptive Resolution Pooling and Attention Network (ARPA-N), a CNN architecture for irregular spectrogram dimensions. ARPA-N integrates CBAM spatial attention as a learned noise suppressor, producing attention maps that localize true call structure and avoid the global, non-biological cues exploited by standard CNNs on long-window data. Under GetNetUPAM, ARPA-N generalizes robustly across diverse environmental regimes. In the zero-training support Balleny Islands region, it reduces false positives per hour by over an order of magnitude (approximately 10x) at fixed 90 percent recall, yielding consistently improved metrics across folds. These advances provide a reproducible benchmark and move UPAM toward scalable, deployment-reliable ecological monitoring.

cs.SD↗