SearcharxivSearch

arXiv subjects

Nicolas Garnier

Publications and source records attributed to Nicolas Garnier.

At least 19 recordsLinked to original sources

Entrainment of the suprachiasmatic nucleus network by a light-dark cycle

The synchronization of biological activity with the alternation of day and night (circadian rhythm) is performed in the brain by a group of neurons, constituting the suprachiasmatic nucleus (SCN). The SCN is divided into two subgroups of oscillating cells: the ventro-lateral (VL) neurons, which are exposed to light (photic signal) and the dorso-medial (DM) neurons which are coupled to the VL cells. When the coupling between these neurons is strong enough, the system synchronizes with the photic period. Upon increasing the cell coupling, the entrainment of the DM cells has been recently shown to occur via a very sharp (jumping) transition when the period of the photic input is larger than the intrinsic period of the cells. Here, we characterize this transition with a simple realistic model. We show that two bifurcations possibly lead to the disappearance of the endogenous mode. Using a mean field model, we show that the jumping transition results from a supercritical Hopf-like bifurcation. This finding implies that both the period and strength of the stimulating photic signal, and the relative fraction of cells in the VL and DM compartments are crucial in determining the synchronization of the system.

nlin.AO

Information theory for non-stationary processes with stationary increments

We describe how to analyze the wide class of non stationary processes with stationary centered increments using Shannon information theory. To do so, we use a practical viewpoint and define ersatz quantities from time-averaged probability distributions. These ersatz versions of entropy, mutual information and entropy rate can be estimated when only a single realization of the process is available. We abundantly illustrate our approach by analyzing Gaussian and non-Gaussian self-similar signals, as well as multi-fractal signals. Using Gaussian signals allow us to check that our approach is robust in the sense that all quantities behave as expected from analytical derivations. Using the stationarity (independence on the integration time) of the ersatz entropy rate, we show that this quantity is not only able to fine probe the self-similarity of the process but also offers a new way to quantify the multi-fractality.

cs.IT

Information Theory to probe Intrapartum Fetal Heart Rate Dynamics

Intrapartum fetal heart rate (FHR) monitoring constitutes a reference tool in clinical practice to assess the baby health status and to detect fetal acidosis. It is usually analyzed by visual inspection grounded on FIGO criteria. Characterization of Intrapartum fetal heart rate temporal dynamics remains a challenging task and continuously receives academic research efforts. Complexity measures, often implemented with tools referred to as \emph{Approximate Entropy} (ApEn) or \emph{Sample Entropy} (SampEn), have regularly been reported as significant features for intrapartum FHR analysis. We explore how Information Theory, and especially {\em auto mutual information} (AMI), is connected to ApEn and SampEn and can be used to probe FHR dynamics. Applied to a large (1404 subjects) and documented database of FHR data, collected in a French academic hospital, it is shown that i) auto mutual information outperforms ApEn and SampEn for acidosis detection in the first stage of labor and continues to yield the best performance in the second stage; ii) Shannon entropy increases as labor progresses, and is always much larger in the second stage;iii) babies suffering from fetal acidosis additionally show more structured temporal dynamics than healthy ones and that this progressive structuration can be used for early acidosis detection.

physics.med-ph

Large variability in dynamical transitions in biological systems with quenched disorder

Coherent oscillatory activity can arise spontaneously as a result of increased coupling in a system of excitable and passive cells, each being quiescent in isolation. This can potentially explain the appearance of spontaneous rhythmic contractions in the pregnant uterus close to term. We investigate the transition to periodic activity using a model system comprising a lattice of excitable cells, each being coupled to a variable number of passive cells whose distribution defines a quenched realization (replica) of spatial disorder. Close to the transition between quiescent state and sustained oscillations in the system we observe large fluctuations between different replicas induced by variations in the local density of passive cells around an excitable cell. We demonstrate that the disorder-induced fluctuations can be described in terms of a simple scaling relation which involves the strength of coupling between excitable cells, the mean passive cell density, as well as the logarithm of the system size. Our results can be interpreted as suggesting that larger organs will have greater variability in the onset of persistent activity.

cond-mat.dis-nn

Spatiotemporal chaos: the microscopic perspective

Extended nonequilibrium systems can be studied in the framework of field theory or from dynamical systems perspective. Here we report numerical evidence that the sum of a well-defined number of instantaneous Lyapunov exponents for the complex Ginzburg-Landau equation is given by a simple function of the space average of the square of the macroscopic field. This relationship follows from an explicit formula for the time-dependent values of almost all the exponents.

cond-mat.stat-mech

Self-organized transition to coherent activity in disordered media

Synchronized oscillations are of critical functional importance in many biological systems. We show that such oscillations can arise without centralized coordination in a disordered system of electrically coupled excitable and passive cells. Increasing the coupling strength results in waves that lead to coherent periodic activity, exhibiting cluster, local and global synchronization under different conditions. Our results may explain the self-organized transition in a pregnant uterus from transient, localized activity initially to system-wide coherent excitations just before delivery.

nlin.AO

Fluctuation-dissipation relation on a Melde string in a turbulent flow, considerations on a "dynamical temperature"

We report on measurements of the transverse fluctuations of a string in a turbulent air jet flow. Harmonic modes are excited by the fluctuating drag force, at different wave-numbers. This simple mechanical probe makes it possible to measure excitations of the flow at specific scales, averaged over space and time: it is a scale-resolved, global measurement. We also measure the dissipation associated to the string motion, and we consider the ratio of the fluctuations over dissipation (FDR). In an exploratory approach, we investigate the concept of {\it effective temperature} defined through the FDR. We compare our observations with other definitions of temperature in turbulence. From the theory of Kolmogorov (1941), we derive the exponent -11/3 expected for the spectrum of the fluctuations. This simple model and our experimental results are in good agreement, over the range of wave-numbers, and Reynolds number accessible ($74000 \leq Re \leq 170000$).

cond-mat.stat-mech

Reflexion and Diffraction of Internal Waves analyzed with the Hilbert Transform

We apply the Hilbert transform to the physics of internal waves in two-dimensional fluids. Using this demodulation technique, we can discriminate internal waves propagating in different directions: this is very helpful in answering several fundamental questions in the context of internal waves. We focus more precisely in this paper on phenomena associated with dissipation, diffraction and reflection of internal waves.

physics.flu-dyn

Work and dissipation fluctuations near the stochastic resonance of a colloidal particle

We study experimentally the fluctuations of the injected and dissipated energy in a system of a colloidal particle trapped in a double well potential periodically modulated by an external perturbation. The work done by the external force and the dissipated energy are measured close to the stochastic resonance where the injected power is maximum. We show that the steady state fluctuation theorem holds in this system.

cond-mat.soft

Fluctuations of the total entropy production in stochastic systems

Fluctuations of the excess heat in an out of equilibrium steady state are experimentally investigated in two stochastic systems : an electric circuit with an imposed mean current and a harmonic oscillator driven out of equilibrium by a periodic torque. In these two linear systems, we study excess heat that represents the difference between the dissipated heat out of equilibrium and the dissipated heat at equilibrium. Fluctuation theorem holds for the excess heat in the two experimental systems for all observation times and for all fluctuation magnitudes.

cond-mat.stat-mech

Thermodynamic time asymmetry in nonequilibrium fluctuations

We here present the complete analysis of experiments on driven Brownian motion and electric noise in a $RC$ circuit, showing that thermodynamic entropy production can be related to the breaking of time-reversal symmetry in the statistical description of these nonequilibrium systems. The symmetry breaking can be expressed in terms of dynamical entropies per unit time, one for the forward process and the other for the time-reversed process. These entropies per unit time characterize dynamical randomness, i.e., temporal disorder, in time series of the nonequilibrium fluctuations. Their difference gives the well-known thermodynamic entropy production, which thus finds its origin in the time asymmetry of dynamical randomness, alias temporal disorder, in systems driven out of equilibrium.

cond-mat.stat-mech

Entropy production and time asymmetry in nonequilibrium fluctuations

The time-reversal symmetry of nonequilibrium fluctuations is experimentally investigated in two out-of-equilibrium systems namely, a Brownian particle in a trap moving at constant speed and an electric circuit with an imposed mean current. The dynamical randomness of their nonequilibrium fluctuations is characterized in terms of the standard and time-reversed entropies per unit time of dynamical systems theory. We present experimental results showing that their difference equals the thermodynamic entropy production in units of Boltzmann's constant.

cond-mat.stat-mech

Fluctuation theorems for harmonic oscillators

We study experimentally the thermal fluctuations of energy input and dissipation in a harmonic oscillator driven out of equilibrium, and search for Fluctuation Relations. We study transient evolution from the equilibrium state, together with non equilibrium steady states. Fluctuations Relations are obtained experimentally for both the work and the heat, for the stationary and transient evolutions. A Stationary State Fluctuation Theorem is verified for the two time prescriptions of the torque. But a Transient Fluctuation Theorem is satisfied for the work given to the system but not for the heat dissipated by the system in the case of linear forcing. Experimental observations on the statistical and dynamical properties of the fluctuation of the angle, we derive analytical expressions for the probability density function of the work and the heat. We obtain for the first time an analytic expression of the probability density function of the heat. Agreement between experiments and our modeling is excellent.

cond-mat.stat-mech

Experimental study of work fluctuations in a harmonic oscillator

The work fluctuations of a harmonic oscillator in contact with a thermostat and driven out of equilibrium by an external force are studied experimentally. For the work both the transient and stationary state fluctuation theorems hold. The finite time corrections are very different from those of a first order Langevin equation. The heat and work fluctuations are studied when a periodic forcing is applied to the oscillator. The importance of the choice of the ''good work'' to compute the free energy from the Jarzinsky equality is discussed.

cond-mat.stat-mech

Nonequilibrium fluctuations in a resistor

In small systems where relevant energies are comparable to thermal agitation, fluctuations are of the order of average values. In systems in thermodynamical equilibrium, the variance of these fluctuations can be related to the dissipation constant in the system, exploiting the Fluctuation-Dissipation Theorem (FDT). In non-equilibrium steady systems, Fluctuations Theorems (FT) additionally describe symmetry properties of the probability density functions (PDFs) of the fluctuations of injected and dissipated energies. We experimentally probe a model system: an electrical dipole driven out of equilibrium by a small constant current $I$, and show that FT are experimentally accessible and valid. Furthermore, we stress that FT can be used to measure the dissipated power $\bar{\cal P}=RI^2$ in the system by just studying the PDFs symmetries.

cond-mat.stat-mech

Effects of curvature on hydrothermal waves instability of radial thermocapillary flows

The stability of a thermocapillary flow in an extended cylindrical geometry is analyzed. This flow occurs in a thin liquid layer with a disk shape when a radial temperature gradient is applied along the horizontal free surface. Besides the aspect ratio, a second parameter related to the local curvature is introduced to describe completely the geometrical effects. We recover classical hydrothermal waves as predicted by Smith and Davis but the properties of these waves are shown to evolve with the curvature parameter, thus leading to a non uniform pattern over the cell. Moreover, it is shown that the problem is not invariant with respect to the exchange of the hot and cold sides.

physics.flu-dyn

Nonlinear dynamics of waves and modulated waves in 1D thermocapillary flows. I: General presentation and periodic solutions

We present experimental results on hydrothermal traveling-waves dynamics in long and narrow 1D channels. The onset of primary traveling-wave patterns is briefly presented for different fluid heights and for annular or bounded channels, i.e., within periodic or non-periodic boundary conditions. For periodic boundary conditions, by increasing the control parameter or changing the discrete mean-wavenumber of the waves, we produce modulated waves patterns. These patterns range from stable periodic phase-solutions, due to supercritical Eckhaus instability, to spatio-temporal defect-chaos involving traveling holes and/or counter-propagating-waves competition, i.e., traveling sources and sinks. The transition from non-linearly saturated Eckhaus modulations to transient pattern-breaks by traveling holes and spatio-temporal defects is documented. Our observations are presented in the framework of coupled complex Ginzburg-Landau equations with additional fourth and fifth order terms which account for the reflection symmetry breaking at high wave-amplitude far from onset. The second part of this paper (nlin.PS/0208030) extends this study to spatially non-periodic patterns observed in both annular and bounded channel.

nlin.PS

Nonlinear dynamics of waves and modulated waves in 1D thermocapillary flows. II: Convective/absolute transitions

We present experimental results on hydrothermal waves in long and narrow 1D channels. In a bounded channel, we describe the primary and secondary instabilities leading to waves and modulated waves in terms of convective/absolute transitions. Because of on the combined effect of finite group velocity and of the presence of boundaries, the wave-patterns are non-uniform in space. We also investigate non-uniform wave-patterns observed in an annular channel in the presence of sources and sinks of hydrothermal waves. We connect our observations with the complex Ginzburg-Landau model equation in the very same way as in the first part of the paper (nlin.PS/0208029).

nlin.PS