arXiv subjects

Nir Gov

Publications and source records attributed to Nir Gov.

At least 19 recordsLinked to original sources

arXiv2025

Maximal response to a mechanical leader at critical group size in ant collectives

It is widely recognized that biological collectives operate near criticality to amplify their capability of collective response. The peak in susceptibility near criticality renders these groups highly responsive to external stimuli. While this phenomenon has been recognized and supported by evidence from theory, a direct experimental demonstration has been elusive. To bridge this gap, here we record the response of a group of Paratrechina longicornis ants to external stimuli as they join efforts to carry food to their nest. Using a robotic system that mimics a transient leader, we apply tactile ant-scale forces and measure the group's response at sub, near, and supercritical regimes. Supported by theory and simulations, we provide direct experimental evidence to demonstrate that at critical group size, the collective response of the ants to an external force is maximally amplified.

physics.bio-ph↗

arXiv2025

Chemotaxis-Driven Instabilities Govern Size, Shape and Migration Efficiency of Multicellular Clusters

The collective chemotaxis of multicellular clusters is an important phenomenon in various physiological contexts, ranging from embryonic development to cancer metastasis. Such clusters often display interesting shape dynamics and instabilities, but their physical origin, functional benefits, and role in overall chemotactic migration remain unclear. Here, we combine computational modeling and experimental observations of malignant lymphocyte cluster migration in vitro to understand how these dynamics arise from an interplay of chemotactic response and inter-cellular interactions. Our cell-based computational model incorporates active propulsion of cells, contact inhibition of locomotion, chemoattractant response, as well as alignment, adhesive, and exclusion interactions between cells. We find that clusters remain fluid and maintain cohesive forward migration in low chemoattractant gradients. However, above a threshold gradient, clusters display an instability driven by local cluster-shape dependent velocity differentials that causes them to elongate perpendicular to the gradient and eventually break apart. Comparison with our in vitro data shows the predicted transition to the cluster instability regime with increased gradient, as well as quantitative agreement with key features such as cluster aspect ratio, orientation, and breaking frequency. This instability naturally limits the size of multicellular aggregates, and, in addition, clusters in the instability regime display optimal forward migration speeds, suggesting functional implications in vivo. Our work provides valuable insights into generic instabilities of chemotactic clusters, elucidates physical factors that could contribute to metastatic spreading, and can be extended to other living or synthetic systems of active clusters.

q-bio.TO↗

arXiv2025

Photometric Decision-Making During the Dawn Choruses of Cicadas

We report the first quantitative study of the onset of dawn choruses of cicadas in several natural habitats. A time-frequency analysis of the acoustical signals is used to define an order parameter for the development of collective singing. The ensemble of recordings reveals that the chorus onset times accurately track the changing sunrise times over the course of many weeks, occurring within civil twilight at a solar elevation of -$3.8^\circ \pm 0.2^\circ$. Despite day-to-day variations in the amplitude of fully developed choruses, the order parameter data collapse to a common sigmoidal curve when scaled by those amplitudes and shifted by the onset time, revealing a characteristic rise time of ~60 s for a chorus to reach saturation amplitude. The results are used to obtain the cumulative distribution function of singing as a function of ground illumination, from which is obtained a generalized susceptibility which exhibits a narrow peak with a half-width of $\sim\! 12\%$. The variance of the order parameter exhibits a similar peak, suggesting that a generalized fluctuation-dissipation theorem holds for this system. A model of decision-making under ramps of a control parameter is developed and can achieve a quantitative match to the data. It suggest that sharpness of the susceptibility peak reflects cooperative decision-making arising from acoustic communication.

cond-mat.soft↗

arXiv2024

Motility driven glassy dynamics in confluent epithelial monolayers

As wounds heal, embryos develop, cancer spreads, or asthma progresses, the cellular monolayer undergoes glass transition between solid-like jammed and fluid-like flowing states. During some of these processes, the cells undergo an epithelial-to-mesenchymal transition (EMT): they acquire in-plane polarity and become motile. Thus, how motility drives the glassy dynamics in epithelial systems is critical for the EMT process. However, no analytical framework that is indispensable for deeper insights exists. Here, we develop such a theory inspired by a well-known glass theory. One crucial result of this work is that the confluency affects the effective persistence time-scale of active force, described by its rotational diffusivity, $D_r^{\text{eff}}$. $D_r^{\text{eff}}$ differs from the bare rotational diffusivity, $D_r$, of the motile force due to cell shape dynamics, which acts to rectify the force dynamics: $D_r^{\text{eff}}$ is equal to $D_r$ when $D_r$ is small and saturates when $D_r$ is large. We test the theoretical prediction of $D_r^{\text{eff}}$ and how it affects the relaxation dynamics in our simulations of active Vertex model. This novel effect of $D_r^{\text{eff}}$ is crucial to understanding the new and previously published simulation data of active glassy dynamics in epithelial monolayers.

cond-mat.soft↗

arXiv2024

Numerical studies of triangulated vesicles with anisotropic membrane inclusions

In this study, we implement the deviatoric curvature model to examine dynamically triangulated surfaces with anisotropic membrane inclusions. The Monte-Carlo numerical scheme is devised to not only minimize the total bending energy of the membrane but also the in-plane nematic order of the inclusions by considering the mismatch between the curvature of the membrane and the intrinsic curvature of the inclusion. Neighboring inclusions can either attract with nearest-neighbor interaction or with a nematic interaction derived from liquid crystal theory. Orientational order determines whether vesicles fully covered with inclusions result in bulbs connected by necks or long tubes. Remarkably, when inclusions on vesicles with no vacancies interact non-nematically, a spontaneous local order can lead to a bulb transition which may have implications in cell or organelle division. Furthermore we find that average nematic order is inversely proportional to the number of thin necks formed in the vesicles. Our method shows good convergence and is suitable for further upgrades, for example to vesicles constrained by volume.

cond-mat.soft↗

arXiv2023

Modelling how curved active proteins and shear flow pattern cellular shape and motility

Cell spreading and motility on an adhesive substrate are driven by the active physical forces generated by the actin cytoskeleton. We have recently shown that coupling curved membrane complexes to protrusive forces, exerted by the actin polymerization that they recruit, provides a mechanism that can give rise to spontaneous membrane shapes and patterns. In the presence of an adhesive substrate, this model was shown to give rise to an emergent motile phenotype, resembling a motile cell. Here, we utilize this ``minimal-cell" model to explore the impact of external shear flow on the cell shape and migration on a uniform adhesive flat substrate. We find that in the presence of shear the motile cell reorients such that its leading edge, where the curved active proteins aggregate, faces the shear flow. The flow-facing configuration is found to minimize the adhesion energy by allowing the cell to spread more efficiently over the substrate. For the non-motile vesicle shapes, we find that they mostly slide and roll with the shear flow. We compare these theoretical results with experimental observations, and suggest that the tendency of many cell types to move against the flow may arise from the very general, and non-cell-type-specific mechanism predicted by our model.

cond-mat.soft↗

arXiv2019

The active trap model

Motivated by the dynamics of particles embedded in active gels, both in-vitro and inside the cytoskeleton of living cells, we study an active generalization of the classical trap model. We demonstrate that activity leads to dramatic modifications in the diffusion compared to the thermal case: the mean square displacement becomes sub-diffusive, spreading as a power-law in time, when the trap depth distribution is a Gaussian and is slower than any power-law when it is drawn from an exponential distribution. The results are derived for a simple, exactly solvable, case of harmonic traps. We then argue that the results are robust for more realistic trap shapes when the activity is strong.

physics.bio-ph↗

arXiv2018

Theoretical study of vesicle shapes driven by coupling curved proteins and active cytoskeletal forces

Eukaryote cells have a flexible shape, which dynamically changes according to the function performed by the cell. One mechanism for deforming the cell membrane into the desired shape is through the expression of curved membrane proteins. Furthermore, these curved membrane proteins are often associated with the recruitment of the cytoskeleton, which then applies active forces that deform the membrane. This coupling between curvature and activity was previously explored theoretically in the linear limit of small deformations, and low dimensionality. Here we explore the unrestricted shapes of vesicles that contain active curved membrane proteins, in three-dimensions, using Monte-Carlo numerical simulations. The activity of the proteins is in the form of protrusive forces that push the membrane outwards, as may arise from the cytoskeleton of the cell due to actin or microtubule polymerization occurring near the membrane. For proteins that have an isotropic convex shape, the additional protrusive force enhances their tendency to aggregate and form membrane protrusions (buds). In addition, we find another transition from deformed spheres with necklace type aggregates, to flat pancake-shaped vesicles, where the curved proteins line the outer rim. This second transition is driven by the active forces, coupled to the spontaneous curvature, and the resulting configurations may shed light on the organization of the lamellipodia of adhered and motile cells.

physics.bio-ph↗

arXiv2017

Frustration induced phases in migrating cell clusters

Collective motion of cells is common in many physiological processes, including tissue development, repair, and tumor formation. Recent experiments have shown that certain malignant cancer cells form clusters in a chemoattractant gradient, which display three different phases of motion: translational, rotational, and random. Intriguingly, all three phases are observed simultaneously, with clusters spontaneously switching between these modes of motion. The origin of this behavior is not understood at present, especially the robust appearance of cluster rotations. Guided by experiments on the motion of two-dimensional clusters in-vitro, we developed an agent based model in which the cells form a cohesive cluster due to attractive and alignment interactions but with potentially different behaviors based on their local environment. We find that when cells at the cluster rim are more motile, all three phases of motion coexist, in excellent agreement with the observations. Using the model we can identify that the transitions between different phases are driven by a competition between an ordered rim and a disordered core accompanied by the creation and annihilation of topological defects in the velocity field. The model makes definite predictions regarding the dependence of the motility phase of the cluster on its size and external chemical gradient, which agree with our experimental data. Our results suggest that heterogeneous behavior of individuals, based on local environment, can lead to novel, experimentally observed phases of collective motion.

physics.bio-ph↗

arXiv2005

Dynamics of membranes driven by actin polymerization

A motile cell, when stimulated, shows a dramatic increase in the activity of its membrane, manifested by the appearance of dynamic membrane structures such as lamellipodia, filopodia and membrane ruffles. The external stimulus turns on membrane bound activators, like Cdc42 and PIP2, which cause increased branching and polymerization of the actin cytoskeleton in their vicinity leading to a local protrusive force on the membrane. The emergence of the complex membrane structures is a result of the coupling between the dynamics of the membrane, the activators and the protrusive forces. We present a simple model that treats the dynamics of a membrane under the action of actin polymerization forces that depend on the local density of freely diffusing activators on the membrane. We show that, depending on the spontaneous membrane curvature associated with the activators, the resulting membrane motion can be wave-like, corresponding to membrane ruffling and actin-waves, or unstable, indicating the tendency of filopodia to form. Our model also quantitatively explains a variety of related experimental observations and makes several testable predictions.

cond-mat.soft↗

arXiv2003

Rychtmyer-Meshkov instability and solid $^4$He melting driven by acoustic pulse

Recent experiments have shown remarkable dynamics of solid $^4$He melting and growth, driven by the normal incidence of an acoustic pulse on the solid-liquid interface. The theory of solid growth/melting, driven by the radiation pressure of the acoustic pulse, accounts well for the temperature dependence of the measured data. There is however an observed source of extra, temperature-independent, melting. We here propose that this extra melting is due to solid-liquid mixing (and consequent melting) at the interface, in a process similar to the Richtmyer-Meshkov instability: Initial undulations of the rough interface, grow when accelerated by the acoustic pressure oscillations. This model predicts a temperature-independent extra melting and its dependence on the acoustic power, which is in agreement with the measured data.

cond-mat↗

arXiv2002

Non-adiabatic dissociation of molecules and BEC loss due to shock-waves

Recent experiments have shown the likely appearance of coherent BEC atom-molecule oscillations in the vicinity of a Feshbach resonance. In addition, a new loss mechanism was observed, whereby the loss of atoms from the BEC is inversely dependent on the rate of change of the applied magnetic field. We present here a phenomenological model which gives a good description of the scaling properties of this new decay process, by attributing it to non-adiabatic dissociation of molecules by a propagating shock-wave. The model has only two free parameters, which specify the size of the "shocked-region", and can be readily tested by future experiments.

cond-mat.soft↗

arXiv2002

Dipolar corrections to the static magnetic susceptibility of condensed $^3$He

We examine the consequences of a recent model describing correlated zero-point polarization of the electronic cloud in solid $^3$He. This polarization arises from the highly anisotropic and correlated dynamic mixing of the $s$ and $p$ electronic levels ($\sim1$%). The magnetic polarization introduces a small paramagnetic correction, of $1-0.1$%, to the static susceptibility of condensed $^3$He. This correction could explain recent measurements in liquid $^3$He.

cond-mat↗

arXiv2002

Velocity dependent interactions and a new sum rule in bcc He

Recent neutron scattering experiments [PRL,{\bf 88},p.195301 (2002)] on solid $^4$He, discovered a new optic-like mode in the bcc phase. This excitation was predicted by a recently proposed model that describes the correlated atomic zero-point motion in bcc Helium in terms of dynamic electric dipole moments. Modulations of the relative phase of these dipoles between different atoms describes the anomalously soft T$_1$(110) phonon and two new optic-like modes, one of which was recently found in the neutron scattering experiments. In this work we show that the correlated dipolar interactions can be written as a velocity dependent interaction. This then results in a modified f-sum rule for the T$_1$(110) phonon, in good agreement with the recent experimental data.

cond-mat↗

arXiv2001

Vortex-loops and solid nucleation in superfluid $^4$He and $^3$He

We propose a new model for the nature of the nucleation of solid from the superfluid phases of $^4$He and $^3$He. Unique to the superfluid phases the solid nucleation involves an extremely fast solidification front. This results in a local release of pressure and a velocity field in the superfluid. The superfluid velocity in turn facilitates the nucleation of vortex-loops. The kinetic energy gain of this process balances the surface tension, as the solid surface is quickly covered by many vortex-loops ("hairy snow-ball"). We show that this scenario gives good agreement with experiments on heterogeneous nucleation, which differ with the classical theory of homogeneous nucleation by 8 orders of magnitude. We propose several experiments that could show the involvement of vortices with solid nucleation.

cond-mat↗

arXiv2001

Quantum nature of dislocations in pure bcc Helium

Recent experiments show the thermal growth of dislocation lines in unlta-pure bcc $^{3}$He. The activation energy for the growth of the dislocation lines is found to agree with the activation energy of mass diffusion. We propose that these dislocations are topological defects in the phase of the complex order-parameter which describes the dynamic zero-point atomic correlations, unique to the bcc phase. These is a shear strain field associated with these topological defects. We show that the smallest topological defect is a localized excitation, a loop-defect, which leads to the exponential growth of the dislocation lines with temperature.

cond-mat↗

arXiv2000

Bcc ^4He as a Coherent Quantum Solid: "Super-Solid" ?

In this work we investigate the quantum nature of bcc $^{4}$He. We show that it is a solid phase with an Off-Diagonal Long Range Order of coherently oscillating local electric dipole moments. These dipoles arise from the correlated zero-point motion of the atoms in the crystal potential, which oscillate in synchrony so that the dipolar interaction energy is minimized. This coherent state has a three-component complex order parameter. The condensation energy of these dipoles in the bcc phase further stabilizes it over the hcp phase at finite temperatures. This condensation of the dipoles is not a 'super-solid'. We further show that there can be fermionic excitations of this ground-state and predict that they form an optic-like branch in the (110) direction.

cond-mat↗

arXiv2000

Coherent dipolar correlations in the ground-state of Kagome frustrated antiferromagnets

We propose a new model for the nature of the low temperature phase of a geometrically frustrated antiferromgnet (AFM) with a Kagome lattice, SrCr$_{8-x}$Ga$_{4+x}$O$_{19}$. We propose that the long-range dipolar interaction between the magnetic Cr$^{3+}$ ions introduces correlations in their dynamics. The dipolar ground-state has the spins performing correlated zero-point oscillations in a coherent state with a well defined global phase and a complex order-parameter (i.e. Off-Diagonal Long Range Order). We calculate the magnon excitations of such a dipolar array and we find good agreement with the spin-wave velocities infered from measurements of the specific-heat. Various experimental properties of these materials are naturally explained by such a model.

cond-mat↗