arXiv subjects

O. Bénichou

Publications and source records attributed to O. Bénichou.

At least 37 records · Page 2Linked to original sources

arXiv2015

Nonlinear response and emerging nonequilibrium micro-structures for biased diffusion in confined crowding environments

We study analytically the dynamics and the micro-structural changes of a host medium caused by a driven tracer particle moving in a confined, quiescent molecular crowding environment. Imitating typical settings of active micro-rheology experiments, we consider here a minimal model comprising a geometrically confined lattice system -- a two-dimensional strip-like or a three-dimensional capillary-like -- populated by two types of hard-core particles with stochastic dynamics -- a tracer particle driven by a constant external force and bath particles moving completely at random. Resorting to a decoupling scheme, which permits us to go beyond the linear-response approximation (Stokes regime) for arbitrary densities of the lattice gas particles, we determine the force-velocity relation for the tracer particle and the stationary density profiles of the host medium particles around it. These results are validated a posteriori by extensive numerical simulations for a wide range of parameters. Our theoretical analysis reveals two striking features: a) We show that, under certain conditions, the terminal velocity of the driven tracer particle is a nonmonotonic function of the force, so that in some parameter range the differential mobility becomes negative, and b) the biased particle drives the whole system into a nonequilibrium steady-state with a stationary particle density profile past the tracer, which decays exponentially, in sharp contrast with the behavior observed for unbounded lattices, where an algebraic decay is known to take place.

cond-mat.stat-mech↗

arXiv2015

Diffusion and subdiffusion of interacting particles on comb-like structures

We study the dynamics of a tracer particle (TP) on a comb lattice populated by randomly moving hard-core particles in the dense limit. We first consider the case where the TP is constrained to move on the backbone of the comb only, and, in the limit of high density of particles, we present exact analytical results for the cumulants of the TP position, showing a subdiffusive behavior $\sim t^{3/4}$. At longer times, a second regime is observed, where standard diffusion is recovered, with a surprising non analytical dependence of the diffusion coefficient on the particle density. When the TP is allowed to visit the teeth of the comb, based on a mean-field-like Continuous Time Random Walk description, we unveil a rich and complex scenario, with several successive subdiffusive regimes, resulting from the coupling between the inhomogeneous comb geometry and particle interactions. Remarkably, the presence of hard-core interactions speeds up the TP motion along the backbone of the structure in all regimes.

cond-mat.stat-mech↗

arXiv2015

Mean perimeter of the convex hull of a random walk in a semi-infinite medium

We study various properties of the convex hull of a planar Brownian motion, defined as the minimum convex polygon enclosing the trajectory, in the presence of an infinite reflecting wall. Recently, in a Rapid Communication [Phys. Rev. E \textbf{91}, 050104(R) (2015)], we announced that the mean perimeter of the convex hull at time $t$, rescaled by $\sqrt{Dt}$, is a non-monotonous function of the initial distance to the wall. In the present article, we first give all the details of the derivation of this mean rescaled perimeter, in particular its value when starting from the wall and near the wall. We then determine the physical mechanism underlying this surprising non-monotonicity of the mean rescaled perimeter by analyzing the impact of the wall on two complementary parts of the convex hull. Finally, we provide a further quantification of the convex hull by determining the mean length of the portion of the reflecting wall visited by the Brownian motion as a function of the initial distance to the wall.

cond-mat.stat-mech↗

arXiv2015

Optimal strategy to capture a skittish lamb wandering near a precipice

We study the splitting probabilities for a one-dimensional Brownian motion in a cage whose two boundaries move at constant speeds $c_1$ and $c_2$. This configuration corresponds to the capture of a diffusing, but skittish lamb, with an approaching shepherd on the left and a precipice on the right. We derive compact expressions for these splitting probabilities when the cage is expanding. We also obtain the time-dependent first-passage probability to the left boundary, as well as the splitting probability to this boundary, when the cage is either expanding or contracting. The boundary motions have a non-trivial impact on the splitting probabilities, leading to multiple regimes of behavior that depend on the expansion or contraction speed of the cage. In particular, the probability to capture the lamb is maximized when the shepherd moves at a non-zero optimal speed if the initial lamb position and the ratio between the two boundary speeds satisfy certain conditions.

cond-mat.stat-mech↗

arXiv2014

Convex hull of a Brownian motion in confinement

We study the effect of confinement on the mean perimeter of the convex hull of a planar Brownian motion, defined as the minimum convex polygon enclosing the trajectory. We use a minimal model where an infinite reflecting wall confines the walk to its one side. We show that the mean perimeter displays a surprising minimum with respect to the starting distance to the wall and exhibits a non-analyticity for small distances. In addition, the mean span of the trajectory in a fixed direction {$θ\in ]0,π/2[$}, which can be shown to yield the mean perimeter by integration over $θ$, presents these same two characteristics. This is in striking contrast with the one dimensional case, where the mean span is an increasing analytical function. The non-monotonicity in the 2D case originates from the competition between two antagonistic effects due to the presence of the wall: reduction of the space accessible to the Brownian motion and effective repulsion.

cond-mat.stat-mech↗

arXiv2014

Microscopic theory for negative differential mobility in crowded environments

We study the behavior of the stationary velocity of a driven particle in an environment of mobile hard-core obstacles. Based on a lattice gas model, we demonstrate analytically that the drift velocity can exhibit a nonmonotonic dependence on the applied force, and show quantitatively that such negative differential mobility (NDM), observed in various physical contexts, is controlled by both the density and diffusion time scale of obstacles. Our study unifies recent numerical and analytical results obtained in specific regimes, and makes it possible to determine analytically the region of the full parameter space where NDM occurs. These results suggest that NDM could be a generic feature of biased (or active) transport in crowded environments.

cond-mat.stat-mech↗

arXiv2014

Gradual Diffusive Capture: Slow Death by Many Mosquito Bites

We study the dynamics of a single diffusing particle (a "man") with diffusivity $D_M$ that is attacked by another diffusing particle (a "mosquito") with fixed diffusivity $D_m$. Each time the mosquito meets and bites the man, the diffusivity of the man is reduced by a fixed amount, while the diffusivity of the mosquito is unchanged. The mosquito is also displaced by a small distance $\pm a$ with respect to the man after each encounter. The man is defined as dead when $D_M$ reaches zero. At the moment when the man dies, his probability distribution of displacements $x$ is given by a Cauchy form, which asymptotically decays as $x^{-2}$, while the distribution of times $t$ when the man dies asymptotically decays as $t^{-3/2}$, which has the same form as the one-dimensional first-passage probability.

cond-mat.stat-mech↗

arXiv2014

Exit time distribution in spherically symmetric two-dimensional domains

The distribution of exit times is computed for a Brownian particle in spherically symmetric two- dimensional domains (disks, angular sectors, annuli) and in rectangles that contain an exit on their boundary. The governing partial differential equation of Helmholtz type with mixed Dirichlet- Neumann boundary conditions is solved analytically. We propose both an exact solution relying on a matrix inversion, and an approximate explicit solution. The approximate solution is shown to be exact for an exit of vanishing size and to be accurate even for large exits. For angular sectors, we also derive exact explicit formulas for the moments of the exit time. For annuli and rectangles, the approximate expression of the mean exit time is shown to be very accurate even for large exits. The analysis is also extended to biased diffusion. Since the Helmholtz equation with mixed boundary conditions is encountered in microfluidics, heat propagation, quantum billiards, and acoustics, the developed method can find numerous applications beyond exit processes.

physics.comp-ph↗

arXiv2014

Mean exit time for surface-mediated diffusion: spectral analysis and asymptotic behavior

We consider a model of surface-mediated diffusion with alternating phases of pure bulk and surface diffusion. For this process, we compute the mean exit time from a disk through a hole on the circle. We develop a spectral approach to this escape problem in which the mean exit time is explicitly expressed through the eigenvalues of the related self-adjoint operator. This representation is particularly well suited to investigate the asymptotic behavior of the mean exit time in the limit of large desorption rate $λ$. For a point-like target, we show that the mean exit time diverges as $\sqrtλ$. For extended targets, we establish the asymptotic approach to a finite limit. In both cases, the mean exit time is shown to asymptotically increase as $λ$ tends to infinity. We also revise the optimality regime of surface-mediated diffusion. Although the presentation is limited to the unit disk, the spectral approach can be extended to other domains such as rectangles or spheres.

math-ph↗

arXiv2013

Geometric friction directs cell migration

In the absence of environmental cues, a migrating cell performs an isotropic random motion. Recently, the breaking of this isotropy has been observed when cells move in the presence of asymmetric adhesive patterns. However, up to now the mechanisms at work to direct cell migration in such environments remain unknown. Here, we show that a non-adhesive surface with asymmetric micro-geometry consisting of dense arrays of tilted micro-pillars can direct cell motion. Our analysis reveals that most features of cell trajectories, including the bias, can be reproduced by a simple model of active Brownian particle in a ratchet potential, which we suggest originates from a generic elastic interaction of the cell body with the environment. The observed guiding effect, independent of adhesion, is therefore robust and could be used to direct cell migration both in vitro and in vivo.

cond-mat.soft↗

arXiv2013

Fluctuations and correlations of a driven tracer in a hard-core lattice gas

We consider a driven tracer particle (TP) in a bath of hard-core particles undergoing continuous exchanges with a reservoir. We develop an analytical framework which allows us to go beyond the standard force-velocity relation used for this minimal model of active microrheology and quantitatively analyze, for any density of the bath particles, the fluctuations of the TP position and their correlations with the occupation number of the bath particles. We obtain an exact Einstein-type relation which links these fluctuations in the absence of a driving force and the bath particles density profiles in the linear driving regime. For the one-dimensional case we also provide an approximate but very accurate explicit expression for the variance of the TP position and show that it can be a non-monotoneous function of the bath particles density: counter-intuitively, an increase of the density may increase the dispersion of the TP position. We show that this non trivial behavior, which could in principle be observed in active microrheology experiments, is induced by subtle cross-correlations quantified by our approach.

cond-mat.stat-mech↗

arXiv2013

Active transport in dense diffusive single-file systems

We study a minimal model of active transport in crowded single-file environments which generalises the emblematic model of single file diffusion to the case when the tracer particle (TP) performs either an autonomous directed motion or is biased by an external force, while all other particles of the environment (bath) perform unbiased diffusions. We derive explicit expressions, valid in the limit of high density of bath particles, of the full distribution $P_n(X)$ of the TP position and of all its cumulants, for arbitrary values of the bias $f$ and for any time $n$. Our analysis reveals striking features, such as the anomalous scaling $\propto\sqrt{n}$ of all cumulants, the equality of cumulants of the same parity characteristic of a Skellam distribution and a convergence to a Gaussian distribution in spite of asymmetric density profiles of bath particles. Altogether, our results provide the full statistics of the TP position, and set the basis for a refined analysis of real trajectories of active particles in crowded single-file environments.

cond-mat.stat-mech↗

arXiv2012

Reactive conformations and non-Markovian cyclization kinetics of a Rouse polymer

We investigate theoretically the physics of diffusion-limited intramolecular polymer reactions. The present work completes and goes beyond a previous study [Nat. Chem. 4, 268 (2012)] that showed that the distribution of the polymer conformations at the very instant of reaction plays a key role in the cyclization kinetics, and takes explicitly into account the non-Markovian nature of the reactant motion. Here, we present in detail this non-Markovian theory, and compare it explicitly with existing Markovian theories and with numerical stochastic simulations. A large focus is made on the description of the non-equilibrium reactive conformations, with both numerical and analytical tools. We show that the reactive conformations are elongated and are characterized by a spectrum with a slowly decreasing tail, implying that the monomers that neighbor the reactive monomers are significantly shifted at the instant of reaction. We complete the study by deriving explicit formulas for the reaction rates in the Markovian Wilemski-Fixman theory when the reactants are located in arbitrary positions in the chain. We also give a simple scaling argument to understand the existence of two regimes in the reaction time, that come from two possible behaviors of monomer motion which can be either diffusive or subdiffusive.

cond-mat.stat-mech↗

arXiv2012

Exact mean exit time for surface-mediated diffusion

We present an exact expression for the mean exit time through the cap of a confining sphere for particles alternating phases of surface and of bulk diffusion. The present approach is based on an integral equation which can be solved analytically. In contrast to the statement of Berezhkovskii and Barzykin [J. Chem. Phys. 136, 54115 (2012)], we show that the mean exit time can be optimized with respect to the desorption rate, under analytically determined criteria.

cond-mat.stat-mech↗

arXiv2012

Reactive conformations and non-Markovian reaction kinetics of a Rouse polymer searching for a target in confinement

We investigate theoretically a diffusion-limited reaction between a reactant attached to a Rouse polymer and an external fixed reactive site in confinement. The present work completes and goes beyond a previous study [T. Guérin, O. Bénichou and R. Voituriez, Nat. Chem., 4, 268 (2012)] that showed that the distribution of the polymer conformations at the very instant of reaction plays a key role in the reaction kinetics, and that its determination enables the inclusion of non-Markovian effects in the theory. Here, we describe in detail this non-Markovian theory and we compare it with numerical stochastic simulations and with a Markovian approach, in which the reactive conformations are approximated by equilibrium ones. We establish the following new results. Our analysis reveals a strongly non-Markovian regime in 1D, where the Markovian and non-Markovian dependance of the relation time on the initial distance are different. In this regime, the reactive conformations are so different from equilibrium conformations that the Markovian expressions of the reaction time can be overestimated by several orders of magnitudes for long chains. We also show how to derive qualitative scaling laws for the reaction time in a systematic way that takes into account the different behaviors of monomer motion at all time and length scales. Finally, we also give an analytical description of the average elongated shape of the polymer at the instant of the reaction and we show that its spectrum behaves a a slow power-law for large wave numbers.

cond-mat.stat-mech↗

arXiv2012

Kinetics of active surface-mediated diffusion in spherically symmetric domains

We present an exact calculation of the mean first-passage time to a target on the surface of a 2D or 3D spherical domain, for a molecule alternating phases of surface diffusion on the domain boundary and phases of bulk diffusion. We generalize the results of [J. Stat. Phys. {\bf 142}, 657 (2011)] and consider a biased diffusion in a general annulus with an arbitrary number of regularly spaced targets on a partially reflecting surface. The presented approach is based on an integral equation which can be solved analytically. Numerically validated approximation schemes, which provide more tractable expressions of the mean first-passage time are also proposed. In the framework of this minimal model of surface-mediated reactions, we show analytically that the mean reaction time can be minimized as a function of the desorption rate from the surface.

cond-mat.stat-mech↗

arXiv2012

Non-Gaussianity and Dynamical Trapping in Locally Activated Random Walks

We propose a minimal model of \emph{locally-activated diffusion}, in which the diffusion coefficient of a one-dimensional Brownian particle is modified in a prescribed way --- either increased or decreased --- upon each crossing of the origin. Such a local mobility decrease arises in the formation of atherosclerotic plaques due to diffusing macrophage cells accumulating lipid particles. We show that spatially localized mobility perturbations have remarkable consequences on diffusion at all scales, such as the emergence of a non-Gaussian multi-peaked probability distribution and a dynamical transition to an absorbing static state. In the context of atherosclerosis, this dynamical transition can be viewed as a minimal mechanism that causes macrophages to aggregate in lipid-enriched regions and thereby to the formation of atherosclerotic plaques.

cond-mat.stat-mech↗

arXiv2012

Optimizing persistent random searches

We consider a minimal model of persistent random searcher with short range memory. We calculate exactly for such searcher the mean first-passage time to a target in a bounded domain and find that it admits a non trivial minimum as function of the persistence length. This reveals an optimal search strategy which differs markedly from the simple ballistic motion obtained in the case of Poisson distributed targets. Our results show that the distribution of targets plays a crucial role in the random search problem. In particular, in the biologically relevant cases of either a single target or regular patterns of targets, we find that, in strong contrast with repeated statements in the literature, persistent random walks with exponential distribution of excursion lengths can minimize the search time, and in that sense perform better than any Levy walk.

cond-mat.stat-mech↗