arXiv subjects

Oleg V. Gradov

Publications and source records attributed to Oleg V. Gradov.

4 recordsLinked to original sources

arXiv2018

Can graphene bilayers be the membrane mimetic materials?

Since the pioneering works of the founder of membrane mimetic chemistry Janos H. Fendler it is known that a number of atomic or molecular clusters and films (including nanoscale ones) are capable of mimicking the membrane functions. Membrane mimetic materials can be either soft matter or solid state materials. Conducting films (including those with magnetic properties) and semiconductors are also known to possess membrane mimetic properties. If we consider the agent exchange through the membrane in the operator form, the chemical composition of the membranes and their models, as well as the difference between the atomic and molecular clusters or layers become not so essential, and hence, membrane mimetic chemistry of nano- and mesostructures do not differ significantly within the agent-based approach. This invited review containing several parts reflects the main aspects of the author's report at the conference "Graphene: a molecule and 2D-crystal" (September 8-12, 2015, Novosibirsk, Russia) and considers various aspects of the similarity between the graphene nanostructures, membranes and bionic membrane-like nanomaterials.

physics.bio-ph↗

arXiv2018

Can graphene bilayers be the membrane mimetic materials? "Ion channels" in graphene-based nanostructures

The prospects of application of graphene and related structures as the membrane mimetic materials, capable of reproducing several biomembrane functions up to the certain limit, are analyzed in the series of our papers. This paper considers the possibility of the ion channel function modeling using graphene and its derivatives. The physical mechanisms providing selective permeability for different membrane mimetic materials, as well as the limits of the adequate simulation of the transport, catalytic, sensing and electrogenic properties of the cell membrane ion channels using bilayered graphene-based structures are discussed.

q-bio.SC↗

arXiv2018

Multiparametric qualimetric microsurgical scanning chip-lancet model: theoretical metrological and biomedical considerations

The construction of a novel surgical instrument is considered, which is also a probing device providing a signal to the measuring equipment, which after its interpretation allows to obtain useful information about the section quality and the biomaterial properties. We propose here some formalized considerations on the possibility of its implementation for different variables registration. The idea is also extrapolated into the field of micrurgy which refers to the microelectrode techniques and the local potential registration in situ.

q-bio.SC↗

arXiv2015

Cryoelectron Microscopy as a Functional Instrument for Systems Biology, Structural Analysis & Experimental Manipulations with Living Cells. A comprehensive review of the current works

The aim of this paper is to give an introductory review of the cryoelectron microscopy as a complex data source for the most of the system biology branches, including the most perspective non-local approaches known as "localomics" and "dynamomics". A brief summary of various cryoelectron mi-croscopy methods and corresponding system biological ap-proaches is given in the text. The above classification can be considered as a useful framework for the primary comprehen-sions about cryoelectron microscopy aims and instrumental tools. We do not discuss any of these concepts in details, but merely point out that their methodological complexity follows only from the structure-functional complexity of biological systems which are investigated in this manner. We also postu-late that one can employ some of the cryoelectron microscopic techniques not only for observation, but also for modification and structural refunctionalization of some biological and similar soft matter objects and microscopic samples. In other worlds, we start with the cryoelectron microscopy as a tool for the sys-tem biology and progress to its applying as an instrument for system biology and functional biomimetics; i.e. "system cryobi-ology" goes over into "synthetic cryobiology" or "cryogenic biomimetics". All these conclusions can be deduced from the most recent works of the latest years, including just submitted foreign papers. This article provides an up-to-date description of the conceptual basis for the novel view on the computational cryoelectron microscopy (in silico) approaches and the data mining principles which lie at the very foundation of modern structural analysis and reconstruction.

q-bio.SC↗