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Olivier Witteveen

Publications and source records attributed to Olivier Witteveen.

2 recordsLinked to original sources

Statistical mechanics for Scrabble predicts strategy, entropy and language

The crossword-like patterns of tiles in Scrabble form connected graphs of occupied sites on a square lattice. We find the most structureless description that reproduces means and covariances observed in real Scrabble games by adapting a maximum entropy approach to connected graphs. This pairwise model captures the data well, and predicts word-length statistics and geometric features of the Scrabble graphs correctly; in addition, the parameters of this model are interpretable and allow us to understand Scrabble playing strategies. Using this pairwise model, we calculate entropy differences and distinguishability of Scrabble graphs across languages, without having access to the letters on the tiles. Notably, we find that the entropy is predicted better by strategic gameplay -- such as word length on the board -- than lexicon size. Finally, we find that we can use the pairwise model to correctly assign Scrabble graphs to languages, avoiding explicit feature selection and at relatively low computational cost.

physics.bio-ph↗

Optimizing information transmission in optogenetic Wnt signaling

Populations of cells regulate gene expression in response to external signals, but their ability to make reliable collective decisions is limited by both intrinsic noise in molecular signaling and variability between individual cells. In this work, we use optogenetic control of the canonical Wnt pathway as an example to study how reliably information about an external signal is transmitted to a population of cells, and determine an optimal encoding strategy to maximize information transmission from Wnt signals to gene expression. We find that it is possible to reach an information capacity beyond 1 bit only through an appropriate, discrete encoding of signals: using either no Wnt, a short Wnt pulse, or a sustained Wnt signal. By averaging over an increasing number of outputs, we systematically vary the effective noise in the pathway. As the effective noise decreases, the optimal encoding comprises more discrete input signals. These signals do not need to be fine-tuned to achieve near-optimal information transmission. The optimal code transitions into a continuous code in the small-noise limit, which can be shown to be consistent with the Jeffreys prior. We visualize the performance of different signal encodings using decoding maps. Our results suggest optogenetic Wnt signaling allows for regulatory control beyond a simple binary switch, and provides a framework to apply ideas from information processing to single-cell in vitro experiments.

physics.bio-ph↗