arXiv subjects

Omer Tzang

Publications and source records attributed to Omer Tzang.

3 recordsLinked to original sources

arXiv2025

High resolution Fluorescence lifetime IMaging Micro-Endoscopy (FLIMME) using a single multimode fiber

Endoscopic optical imaging using a single multimode fiber (MMF) has emerged as a promising approach for highly compact, minimally invasive, and high-resolution imaging. Unlike conventional fiber bundles, MMF-based endomicroscopes exploit the controlled excitation of multiple spatially overlapping modes in a single MMF. of core diameters of tens of micrometers. to deliver and collect light to form images with sub-micrometer resolution. Here, we introduce a fluorescence lifetime imaging microscopy (FLIM) modality to the MMF endomicroscope. We use amplitude modulation of a 405 nm single-mode light source at radio frequency (RF) and lock-in detection of autofluorescence to obtain intensity and lifetime images at sub-micrometer resolution. We experimentally demonstrate the capability of the ultrathin endomicroscope to perform label-free imaging in thick ex vivo murine submandibular gland tissue. With a temporal resolution of 0.03 ns, the FLIM images show distinguished structures of lifetime differences down to 0.5 ns. The combination of sub-micrometer fluorescence intensity and lifetime images in a minimally invasive endomicroscope opens new avenues for label-free cancer detection.

physics.optics↗

arXiv2018

Wavefront shaping in complex media at 350 KHz with a 1D-to-2D transform

Controlling the propagation and interaction of light in complex media has sparked major interest in the last few years. Unfortunately, spatial light modulation devices suffer from limited speed that precludes real-time applications such as imaging in live tissue. To address this critical problem we introduce a phase-control technique to characterize complex media based on the use of fast 1D spatial light modulators and a 1D-to-2D transformation performed by the same medium being analyzed. We implement the concept using a micro-electro-mechanical grating light valve (GLV) with 1088 degrees of freedom modulated at 350 KHz, enabling unprecedented high-speed wavefront measurements. We continuously measure the transmission matrix, calculate the optimal wavefront and project a focus through various dynamic scattering samples in real-time, all within 2.4 ms per cycle. These results improve prior wavefront shaping modulation speed by more than an order of magnitude and open new opportunities for optical processing using 1D-to-2D transformations.

eess.IV↗

arXiv2017

Wave-front shaping in nonlinear multimode fibers

Recent remarkable progress in wave-front shaping has enabled control of light propagation inside linear media to focus and image through scattering objects. In particular, light propagation in multimode fibers comprises complex intermodal interactions and rich spatiotemporal dynamics. Control of physical phenomena in multimode fibers and its applications is in its infancy, opening opportunities to take advantage of complex mode interactions. In this work, we demonstrate a wave-front shaping approach for controlling nonlinear phenomena in multimode fibers. Using a spatial light modulator at the fiber input and a genetic algorithm optimization, we control a highly nonlinear stimulated Raman scattering cascade and its interplay with four wave mixing via a flexible implicit control on the superposition of modes that are coupled into the fiber. We show for the first time versatile spectrum manipulations including shifts, suppression, and enhancement of Stokes and anti-Stokes peaks. These demonstrations illustrate the power of wave-front shaping to control and optimize nonlinear wave propagation.

nlin.AO↗