arXiv subjects

Oscar Rodriguez

Publications and source records attributed to Oscar Rodriguez.

5 recordsLinked to original sources

arXiv2025

Deep-SITAR: A SITAR-Based Deep Learning Framework for Growth Curve Modeling via Autoencoders

Several approaches have been developed to capture the complexity and nonlinearity of human growth. One widely used is the Super Imposition by Translation and Rotation (SITAR) model, which has become popular in studies of adolescent growth. SITAR is a shape-invariant mixed-effects model that represents the shared growth pattern of a population using a natural cubic spline mean curve while incorporating three subject-specific random effects -- timing, size, and growth intensity -- to account for variations among individuals. In this work, we introduce a supervised deep learning framework based on an autoencoder architecture that integrates a deep neural network (neural network) with a B-spline model to estimate the SITAR model. In this approach, the encoder estimates the random effects for each individual, while the decoder performs a fitting based on B-splines similar to the classic SITAR model. We refer to this method as the Deep-SITAR model. This innovative approach enables the prediction of the random effects of new individuals entering a population without requiring a full model re-estimation. As a result, Deep-SITAR offers a powerful approach to predicting growth trajectories, combining the flexibility and efficiency of deep learning with the interpretability of traditional mixed-effects models.

stat.ML↗

arXiv2023

Learning quantities of interest from parametric PDEs: An efficient neural-weighted Minimal Residual approach

The efficient approximation of parametric PDEs is of tremendous importance in science and engineering. In this paper, we show how one can train Galerkin discretizations to efficiently learn quantities of interest of solutions to a parametric PDE. The central component in our approach is an efficient neural-network-weighted Minimal-Residual formulation, which, after training, provides Galerkin-based approximations in standard discrete spaces that have accurate quantities of interest, regardless of the coarseness of the discrete space.

math.NA↗

arXiv2021

Predicting Mood Disorder Symptoms with Remotely Collected Videos Using an Interpretable Multimodal Dynamic Attention Fusion Network

We developed a novel, interpretable multimodal classification method to identify symptoms of mood disorders viz. depression, anxiety and anhedonia using audio, video and text collected from a smartphone application. We used CNN-based unimodal encoders to learn dynamic embeddings for each modality and then combined these through a transformer encoder. We applied these methods to a novel dataset - collected by a smartphone application - on 3002 participants across up to three recording sessions. Our method demonstrated better multimodal classification performance compared to existing methods that employed static embeddings. Lastly, we used SHapley Additive exPlanations (SHAP) to prioritize important features in our model that could serve as potential digital markers.

cs.LG↗

arXiv2021

Diversity in immunogenomics: the value and the challenge

With the advent of high-throughput sequencing technologies, the fields of immunogenomics and adaptive immune receptor repertoire research are facing both opportunities and challenges. Adaptive immune receptor repertoire sequencing (AIRR-seq) has become an increasingly important tool to characterize T and B cell responses in settings of interest. However, the majority of AIRR-seq studies conducted so far were performed in individuals of European ancestry, restricting the ability to identify variation in human adaptive immune responses across populations and limiting their applications. As AIRR-seq studies depend on the ability to assign VDJ sequence reads to the correct germline gene segments, efforts to characterize the genomic loci that encode adaptive immune receptor genes in different populations are urgently needed. The availability of comprehensive germline gene databases and further applications of AIRR-seq studies to individuals of non-European ancestry will substantially enhance our understanding of human adaptive immune responses, promote the development of effective diagnostics and treatments, and eventually advance precision medicine.

q-bio.GN↗

arXiv2013

Perturbations to aquatic photosynthesis due to high-energy cosmic ray induced muon flux in the extragalactic shock model

We modify a mathematical model of photosynthesis to quantify the perturbations that high energy muons could make on aquatic primary productivity. Then we apply this in the context of the extragalactic shock model, according to which Earth receives an enhanced dose of high-energy cosmic rays when it is at the galactic north. We obtain considerable reduction in the photosynthesis rates, consistent with potential drops in biodiversity.

astro-ph.EP↗