arXiv subjects

P. Bakule

Publications and source records attributed to P. Bakule.

4 recordsLinked to original sources

arXiv2026

Controlled kHz laser-driven electron irradiations for pre-clinical applications

We report the first in-air irradiations of biological samples with kHz laser-driven electrons with beam energy 20 MeV, high-energy tail extending to 40 MeV, and average dose rate up to 30 Gy/min. An in-house procedure has been developed to characterize and deliver on-demand (i.e. pre-agreed date and time) the target electron beam energy, dose and dose uniformity. We present a tolerance analysis on the laser electron parameters, highlighting the importance of beam stability for precise irradiations of in vivo zebrafish embryos and in vitro U251 glioblastoma cell line. The observed improvement in the survival rate of the zebrafish embryos, combined with unchanged cytotoxicity in the cell cultures, indicates promising results for normal tissue sparing while maintaining anticancer efficacy. The pre-clinical results of this work represent an important milestone towards the clinical translation of laser-plasma accelerators.

physics.med-ph↗

arXiv2023

Ultrarelativistic electron beams accelerated by terawatt scalable kHz laser

We show the laser-driven acceleration of unprecedented, collimated ($ 2 \ \mathrm{mrad} $ divergence), and quasi-monoenergetic ($ 25 \ \% $ energy spread) electron beams with energy up to $ 50 \ \mathrm{MeV} $ at $ 1 \ \mathrm{kHz} $ repetition rate. The laser driver is a multi-cycle ($ 15 \ \mathrm{fs} $) $ 1 \ \mathrm{kHz} $ optical parametric chirped pulse amplification (OPCPA) system, operating at $ 26 \ \mathrm{mJ} $ ($ 1.7 \ \mathrm{TW} $). The scalability of the driver laser technology and the electron beams reported in this work pave the way towards developing high-brilliance x-ray sources for medical imaging, innovative devices for brain cancer treatment, and represent a step towards the realization of a kHz GeV electron beamline.

physics.plasm-ph↗

arXiv2013

Measurement of muonium emission from silica aerogel

Emission of muonium ($μ^{+}e^{-}$) atoms from silica aerogel into vacuum was observed. Characteristics of muonium emission were established from silica aerogel samples with densities in the range from 29 mg cm$^{-3}$ to 178 mg cm$^{-3}$. Spectra of muonium decay times correlated with distances from the aerogel surfaces, which are sensitive to the speed distributions, follow general features expected from a diffusion process, while small deviations from a simple room-temperature thermal diffusion model are identified. The parameters of the diffusion process are deduced from the observed yields.

physics.atom-ph↗

arXiv1999

Measurement of the 1s-2s energy interval in muonium

The 1s-2s interval has been measured in the muonium ({$μ^+e^-$}) atom by Doppler-free two-photon laser spectroscopy. The frequency separation of the states was determined to be 2 455 528 941.0(9.8) MHz in good agreement with quantum electrodynamics. The muon-electron mass ratio can be extracted and is found to be 206.768 38(17). The result may be interpreted as measurement of the muon-electron charge ratio as $-1- 1.1(2.1)\cdot 10^{-9}$.

hep-ex↗