arXiv subjects

P. Castorina

Publications and source records attributed to P. Castorina.

At least 19 recordsLinked to original sources

arXiv2021

Quantitative predictions of neoadjuvant chemotherapy effects in breast cancer by individual patient data assimililation

Neoadjuvant chemotherapy has been used for breast cancer aiming at downgrading before surgery. In this article we propose a new quantitative analysis of the effects of the neoadjuvant therapy to obtain numerical, personalized, predictions on the shrinkage of the tumor size after the drug doses, by data assimilation of the individual patient. The algorithm has been validated by a sample of 37 patients with histological diagnosis of locally advanced primary breast carcinoma. The biopsy specimen, the initial tumor size and its reduction after each treatment were known for all patients. We find that: a) the measure of tumor size at the diagnosis and after the first dose permits to predict the size reduction for the follow up; b) the results are in agreement with our data sample, within 10-20 %, for about 90% of the patients. The quantitative indications suggest the best time for surgery. The analysis is patient oriented, weakly model dependent and can be applied to other cancer phenotypes.

q-bio.QM↗

arXiv2020

Universality in High Energy Collisions of small and large systems

hep-ph↗

arXiv2020

Containment effort reduction and regrowth patterns of the Covid-19 spreading

In all Countries the political decisions aim to achieve an almost stable configuration with a small number of new infected individuals per day due to Covid-19. When such a condition is reached, the containment effort is usually reduced in favor of a gradual reopening of the social life and of the various economical sectors. However, in this new phase, the infection spread restarts and a quantitative analysis of the regrowth is very useful. We discuss a macroscopic approach which, on the basis of the collected data in the first lockdown, after few days from the beginning of the new phase, outlines different scenarios of the Covid-19 diffusion for longer time. The purpose of this paper is a demonstration-of-concept: one takes simple growth models, considers the available data and shows how the future trend of the spread can be obtained. The method applies a time dependent carrying capacity, analogously to many macroscopic growth laws in biology, economics and population dynamics. The illustrative cases of Singapore, France, Spain and Italy are analyzed.

q-bio.PE↗

arXiv2020

Strangeness enhancement and flow-like effects in $e^+ e^-$ annihilation at high parton density

Strangeness enhancement and collective flow are considered signatures of the quark gluon plasma formation. These phenomena have been detected not only in relativistic heavy ion collisions but also in high energy, high multiplicity events of proton-proton and proton-nucleus ("small systems") scatterings. Indeed, a universal behavior emerges by considering the parton density in the transverse plane as the dynamical quantity to specify the initial condition of the collisions. On the other hand, $e^+ e^-$ annihilation data at LEP and lower energies indicate that there is no strangeness enhancement and no flow-like effect. We show that the parton density in the transverse plane generated in $e^+ e^-$ annihilation at the available energy is too low to expect such effects. The event-by-event multiplicity where strangeness suppression and flow-like phenomenon could show up in $e^+ e^-$ is evaluated.

hep-ph↗

arXiv2020

How macroscopic laws describe complex dynamics: asymptomatic population and CoviD-19 spreading

Macroscopic growth laws, solutions of mean field equations, describe in an effective way an underlying complex dynamics. They are applied to study the spreading of infections, as in the case of CoviD-19, where the counting of the cumulated number $N(t)$ of detected infected individuals is a generally accepted, coarse-grain, variable to understand the epidemic phase. However $N(t)$ does not take into account the unknown number of asymptomatic, not detected, cases $A(t)$. Therefore, the question arises if the observed time series of data of $N(t)$ is a reliable tool for monitoring the evolution of the infectious disease. We study a system of coupled differential equations which includes the dynamics of the spreading among symptomatic and asymptomatic individuals and the strong containment effects due to the social isolation. The solution is therefore compared with a macroscopic law for the population $N(t)$ coming from a single, non-linear, differential equation with no explicit reference to $A(t)$, showing the equivalence of the two methods. Indeed, $N(t)$ takes into account a more complex and detailed population dynamics which permits the evaluation of the number of asymptomatic individuals also. The model is then applied to Covid-19 spreading in Italy where a transition from an exponential behavior to a Gompertz growth for $N(t)$ has been observed in more recent data. Then the information contained in the data analysis of $N(t)$ is reliable to understand the epidemic phase, although it does not describe the total infected population. The asymptomatic population is larger than the symptomatic one in the fast growth phase of the spreading.

q-bio.PE↗

arXiv2020

Data analysis on Coronavirus spreading by macroscopic growth laws

To evaluate the effectiveness of the containment on the epidemic spreading of the new Coronavirus disease 2019, we carry on an analysis of the time evolution of the infection in a selected number of different Countries, by considering well-known macroscopic growth laws, the Gompertz law, and the logistic law. We also propose here a generalization of Gompertz law. Our data analysis permits an evaluation of the maximum number of infected individuals. The daily data must be compared with the obtained fits, to verify if the spreading is under control. From our analysis it appears that the spreading reached saturation in China, due to the strong containment policy of the national government. In Singapore a large growth rate, recently observed, suggests the start of a new strong spreading. For South Korea and Italy, instead, the next data on new infections will be crucial to understand if the saturation will be reached for lower or higher numbers of infected individuals.

physics.soc-ph↗

arXiv2019

High Energy Hadron Production, Self-Organized Criticality and Absorbing State Phase Transition

In high energy nuclear collisions, production rates of light nuclei agree with the predictions of an ideal gas at a temperature $T=155 \pm 10$ MeV. In an equilibrium hadronic medium of this temperature, light nuclei cannot survive. In this contribution, we suggest that the observed behavior is due to an evolution in global non-equilibrium, leading to self-organized criticality and to hadron formation as an absorbing state phase transition for color degrees of freedom. At the confinement point, the initial quark-gluon medium becomes quenched by the vacuum, breaking up into all allowed free hadronic and nuclear mass states, without (or with a very short-live) subsequent formation of thermal hadronic medium.

hep-ph↗

arXiv2019

Dark matter search in a Beam-Dump eXperiment (BDX) at Jefferson Lab -- 2018 update to PR12-16-001

This document complements and completes what was submitted last year to PAC45 as an update to the proposal PR12-16-001 "Dark matter search in a Beam-Dump eXperiment (BDX)" at Jefferson Lab submitted to JLab-PAC44 in 2016. Following the suggestions contained in the PAC45 report, in coordination with the lab, we ran a test to assess the beam-related backgrounds and validate the simulation framework used to design the BDX experiment. Using a common Monte Carlo framework for the test and the proposed experiment, we optimized the selection cuts to maximize the reach considering simultaneously the signal, cosmic-ray background (assessed in Catania test with BDX-Proto) and beam-related backgrounds (irreducible NC and CC neutrino interactions as determined by simulation). Our results confirmed what was presented in the original proposal: with 285 days of a parasitic run at 65 $μ$A (corresponding to $10^{22}$ EOT) the BDX experiment will lower the exclusion limits in the case of no signal by one to two orders of magnitude in the parameter space of dark-matter coupling versus mass.

physics.ins-det↗

arXiv2019

Thermodynamic Geometry of Nambu -- Jona Lasinio model

The formalism of Riemannian geometry is applied to study the phase transitions in Nambu -Jona Lasinio (NJL) model. Thermodynamic geometry reliably describes the phase diagram, both in the chiral limit and for finite quark masses. The comparison between the geometrical study of NJL model and of (2+1) Quantum Chromodynamics at high temperature and small baryon density shows a clear connection between chiral symmetry restoration/breaking and deconfinement/confinement regimes.

nucl-th↗

arXiv2018

Thermodynamic Geometry of Strongly Interacting Matter

The thermodynamic geometry formalism is applied to strongly interacting matter to estimate the deconfinement temperature. The curved thermodynamic metric for Quantum Chromodynamics (QCD) is evaluated on the basis of lattice data, whereas the hadron resonance gas model is used for the hadronic sector. Since the deconfinement transition is a crossover, the geometric criterion used to define the \mbox{(pseudo-)critical} temperature, as a function of the baryonchemical potential $μ_B$, is $R(T,μ_B)=0$, where $R$ is the scalar curvature. The (pseudo-)critical temperature, $T_c$, resulting from QCD thermodynamic geometry is in good agreement with lattice and phenomenological freeze-out temperature estimates. The crossing temperature, $T_h$, evaluated by the hadron resonance gas, which suffers of some model dependence, is larger than $T_c$ (about $20\%$) signaling remnants of confinement above the transition.

nucl-th↗

arXiv2018

Deconfinement Transition Effects on Cosmological Parameters and Primordial Gravitational Wave Spectrum

The cosmological evolution can be described in terms of directly measurable cosmological scalar parameters (deceleration $q$, jerk $j$, snap $s$, etc...) constructed out of high order derivatives of the scale factor. Their behavior at the critical temperature of the Quantum Chromodynamics (QCD) phase transition in early universe could be a specific tool to study the transition, analogously to the fluctuations of conserved charges in QCD. We analyze the effect of the crossover transition from quarks and gluons to hadrons in early universe on the cosmological scalars and on the gravitational wave spectrum, by using the recent lattice QCD equation of state and including the electroweak degrees of freedom and different models of dark matter. Near the transition the cosmological parameters follow the behavior of QCD trace anomaly and of the speed of sound of the entire system. The effects of deconfinement turn out to be more relevant for the modification of the primordial spectrum of gravitational waves and our complete analysis, based on lattice QCD simulations and on the hadron resonance gas below the critical temperature, refines previous results.

hep-ph↗

arXiv2018

Addendum to Strangeness Production and Color Deconfinement

Recent extensive data from the beam energy scan of the STAR collaboration at BNL-RHIC provide the basis for a detailed update for the universal behavior of the strangeness suppression factor gamma_s as function of the initial entropy density, as proposed in our recent paper [1]. [1] P. Castorina, S. Plumari and H. Satz, Int. J. Mod. Phys. E26 (2017) 1750081 (arXiv:1709.02706)

nucl-th↗

arXiv2018

Dark matter search in a Beam-Dump eXperiment (BDX) at Jefferson Lab: an update on PR12-16-001

This document is an update to the proposal PR12-16-001 Dark matter search in a Beam-Dump eXperiment (BDX) at Jefferson Lab submitted to JLab-PAC44 in 2016 reporting progress in addressing questions raised regarding the beam-on backgrounds. The concerns are addressed by adopting a new simulation tool, FLUKA, and planning measurements of muon fluxes from the dump with its existing shielding around the dump. First, we have implemented the detailed BDX experimental geometry into a FLUKA simulation, in consultation with experts from the JLab Radiation Control Group. The FLUKA simulation has been compared directly to our GEANT4 simulations and shown to agree in regions of validity. The FLUKA interaction package, with a tuned set of biasing weights, is naturally able to generate reliable particle distributions with very small probabilities and therefore predict rates at the detector location beyond the planned shielding around the beam dump. Second, we have developed a plan to conduct measurements of the muon ux from the Hall-A dump in its current configuration to validate our simulations.

physics.ins-det↗

arXiv2017

Universal strangeness production and size fluctuactions in small and large systems

Strangeness production in high multiplicity events gives indications on the transverse size fluctuactions in nucleus-nucleus ($AA$), proton-nucleus ($pA$) and proton-proton ($pp$) collisions. In particular the behavior of strange particle hadronization in "small" ($pp,pA$) and "large" ($AA$) initial configurations of the collision can be tested for the specific particle species, for different centralities and for large fluctuations of the transverse size in $pA$ and $pp$ by using the recent ALICE data. A universality of strange hadron production emerges by introducing a dynamical variable proportional to the initial parton density in the transverse plane.

nucl-th↗

arXiv2016

Unruh thermalization, gluon condensation and freeze-out

The deconfinement transition and the hadronization mechanism at high energy are related to the quark-antiquark string breaking and the corresponding temperature depends on the string tension $σ$. In the Unruh scheme of hadron production it turns out $T = \sqrt{σ/2π}$, with $σ\simeq \E$, the vacuum energy density. In heavy ion collisions at lower energy, i.e. large baryonchemical potential, $μ_B$, the dynamics is dominated by Fermi statistics and baryon repulsion. However one can still consider $\E$ as the relevant physical scale and its evaluation as a function of the baryon density, in a nuclear matter approach, gives dynamical information on the $μ_B$ dependence of the hadronization temperature and on the value of the critical end point in the $T-μ_B$ plane.

hep-ph↗

arXiv2016

Universal Strangeness Production in Hadronic and Nuclear Collisions

We show that strangeness suppression in hadronic and nuclear collisions is fully determined by the initial energy density of the collision. The suppression factor $γ_s(s)$, with $\sqrt s$ denoting the collision energy, can be expressed as a universal function of the initial energy density $ε_0(s)$, and the resulting pattern is in excellent agreement with data from $p-p,~p-Pb,~Cu-Cu,~Au-Au$ and $Pb-Pb$ data over a wide range of energies and for different centralities.

hep-ph↗

arXiv2016

Strangeness Production in AA and pp Collisions

Boost-invariant hadron production in high energy collisions occurs in causally disconnected regions of finite space-time size. As a result, globally conserved quantum numbers (charge, strangeness, baryon number) are conserved locally in spatially restricted correlation clusters. Their size is determined by two time scales: the equilibration time specifying the formation of a quark-gluon plasma, and the hadronization time, specifying the onset of confinement. The expected values for these scales provide the theoretical basis for the suppression observed for strangeness production in elementary interactions ($pp$, $e^+e^-$) below LHC energies. In contrast, the space-time superposition of individual collisions in high energy heavy ion interactions leads to higher energy densities, resulting in much later hadronization and hence much larger hadronization volumes. This largely removes the causality constraints and results in an ideal hadronic resonance gas in full chemical equilibrium. In the present paper, we determine the collision energies needed for that; we also estimate when $pp$ collisions reach comparable hadronization volumes and thus determine when strangeness suppression should disappear there as well.

hep-ph↗

arXiv2015

Hawking-Unruh hadronization and strangeness production in high energy collisions

The interpretation of quark ($q$)- antiquark ($\bar q$) pairs production and the sequential string breaking as tunneling through the event horizon of colour confinement leads to a thermal hadronic spectrum with a universal Unruh temperature, $T \simeq 165$ Mev,related to the quark acceleration, $a$, by $T=a/2π$. The resulting temperature depends on the quark mass and then on the content of the produced hadrons, causing a deviation from full equilibrium and hence a suppression of strange particle production in elementary collisions. In nucleus-nucleus collisions, where the quark density is much bigger, one has to introduce an average temperature (acceleration) which dilutes the quark mass effect and the strangeness suppression almost disappears.

hep-ph↗