arXiv subjects

Panagiota Gatoula

Publications and source records attributed to Panagiota Gatoula.

4 recordsLinked to original sources

arXiv2026

EndoFSA: Endoscopic Few-Shot Image Generation via Rank-Constrained Parameter Adaptation

WCE produces large-scale gastrointestinal image data yet pathological findings remain significantly underrepresented limiting the generalization performance of deep-learning based abnormality detection systems. SDG methods offer a practical solution to mitigate this imbalance. However their training directly on scarce abnormal samples often results in instability overfitting and structural distortions. Addressing these challenges requires controlled adaptation mechanisms that preserve anatomical priors while enabling realistic pathological variation. This paper presents EndoFSA a GAN-based model for Endoscopic Few-Shot image generation by Adaptation in WCE imaging. EndoFSA leverages a generator pretrained on abundant normal data and adapts it to abnormal domains using limited number of training samples through a rank-constrained parameter adaptation where only a small number of modulation parameters is updated while the pretrained weights remain frozen. By restricting parameter updates to a low dimensional subspace and incorporating perceptual boundary regularization and cluster-wise diversity control EndoFSA enables efficient model adaptation under limited data conditions and mitigates mode collapse while preserving the anatomical priors learned from normal data. Importantly EndoFSA operates without requiring pixel-level annotations, masks or bounding box supervision. Evaluation on publicly available WCE benchmark datasets spanning various abnormal categories demonstrates that EndoFSA generates abnormal images reproducing real lesions morphology. Moreover in a downstream classification task training an image classifier solely on synthetic abnormal images generated by EndoFSA yields performance comparable to that obtained with real images.

cs.CV↗

arXiv2026

Interpretable Similarity of Synthetic Image Utility

Synthetic medical image data can unlock the potential of deep learning (DL)-based clinical decision support (CDS) systems through the creation of large scale, privacy-preserving, training sets. Despite the significant progress in this field, there is still a largely unanswered research question: "How can we quantitatively assess the similarity of a synthetically generated set of images with a set of real images in a given application domain?". Today, answers to this question are mainly provided via user evaluation studies, inception-based measures, and the classification performance achieved on synthetic images. This paper proposes a novel measure to assess the similarity between synthetically generated and real sets of images, in terms of their utility for the development of DL-based CDS systems. Inspired by generalized neural additive models, and unlike inception-based measures, the proposed measure is interpretable (Interpretable Utility Similarity, IUS), explaining why a synthetic dataset could be more useful than another one in the context of a CDS system based on clinically relevant image features. The experimental results on publicly available benchmark datasets from various color medical imaging modalities including endoscopic, dermoscopic and fundus imaging, indicate that selecting synthetic images of high utility similarity using IUS can result in relative improvements of up to 54.6% in terms of classification performance. The generality of IUS for synthetic data assessment is demonstrated also for grayscale X-ray and ultrasound imaging modalities. IUS implementation is available at https://github.com/innoisys/ius.

cs.CV↗

arXiv2025

Clinical Evaluation of Medical Image Synthesis: A Case Study in Wireless Capsule Endoscopy

Synthetic Data Generation (SDG) based on Artificial Intelligence (AI) can transform the way clinical medicine is delivered by overcoming privacy barriers that currently render clinical data sharing difficult. This is the key to accelerating the development of digital tools contributing to enhanced patient safety. Such tools include robust data-driven clinical decision support systems, and example-based digital training tools that will enable healthcare professionals to improve their diagnostic performance for enhanced patient safety. This study focuses on the clinical evaluation of medical SDG, with a proof-of-concept investigation on diagnosing Inflammatory Bowel Disease (IBD) using Wireless Capsule Endoscopy (WCE) images. Its scientific contributions include a) a novel protocol for the systematic Clinical Evaluation of Medical Image Synthesis (CEMIS); b) a novel variational autoencoder-based model for the generation of high-resolution synthetic WCE images; and c) a comprehensive evaluation of the synthetic images using the CEMIS protocol by 10 international WCE specialists, in terms of image quality, diversity, and realism, as well as their utility for clinical decision-making. The results show that TIDE-II generates clinically plausible, very realistic WCE images, of improved quality compared to relevant state-of-the-art generative models. Concludingly, CEMIS can serve as a reference for future research on medical image-generation techniques, while the adaptation/extension of the architecture of TIDE-II to other imaging domains can be promising.

cs.CV↗

arXiv2023

This Intestine Does Not Exist: Multiscale Residual Variational Autoencoder for Realistic Wireless Capsule Endoscopy Image Generation

Medical image synthesis has emerged as a promising solution to address the limited availability of annotated medical data needed for training machine learning algorithms in the context of image-based Clinical Decision Support (CDS) systems. To this end, Generative Adversarial Networks (GANs) have been mainly applied to support the algorithm training process by generating synthetic images for data augmentation. However, in the field of Wireless Capsule Endoscopy (WCE), the limited content diversity and size of existing publicly available annotated datasets, adversely affect both the training stability and synthesis performance of GANs. Aiming to a viable solution for WCE image synthesis, a novel Variational Autoencoder architecture is proposed, namely "This Intestine Does not Exist" (TIDE). The proposed architecture comprises multiscale feature extraction convolutional blocks and residual connections, which enable the generation of high-quality and diverse datasets even with a limited number of training images. Contrary to the current approaches, which are oriented towards the augmentation of the available datasets, this study demonstrates that using TIDE, real WCE datasets can be fully substituted by artificially generated ones, without compromising classification performance. Furthermore, qualitative and user evaluation studies by experienced WCE specialists, validate from a medical viewpoint that both the normal and abnormal WCE images synthesized by TIDE are sufficiently realistic.

cs.CV↗