arXiv subjects

Panagiotis Fytas

Publications and source records attributed to Panagiotis Fytas.

3 recordsLinked to original sources

arXiv2026

Rethinking Clinical Relevance in Chest X-ray Machine Learning: How Evaluation References Define Performance

Chest X-ray (CXR) machine learning relies heavily on automated evaluation using reference standards that aim to approximate clinical judgment. However, commonly used report-derived labels for pathology classification or generic image quality metrics for reconstruction may not reliably reflect clinical judgment. We systematically investigate how evaluation-reference choices affect model performance and ranking in both pathology classification and image quality assessment (IQA). To enable controlled comparison across evaluation references, we collected paired expert image- and report-derived labels for thoracic findings from a clinical cohort at Cambridge University Hospitals (CUH) and curated a subset of the public MIMIC-CXR dataset, along with expert ratings of diagnostic image quality. We show that for supervised image classifiers (ResNet, DenseNet), several zero-shot and fine-tuned vision-language models (e.g., MedKLIP, GLoRIA, and ConVIRT), changing the label source leads to substantial differences not only in performance estimates but also in model rankings. In parallel, alignment of IQA measures with expert judgment depends heavily on the choice of measure, and commonly used IQA metrics such as SSIM and PSNR often fail to align with expert assessments of diagnostic usability. Our results demonstrate that evaluation choices are crucial: they can determine which models and methods appear best and are therefore selected for further development or deployment. The selection of evaluation references should therefore be treated as a central component of clinical validity in CXR machine learning, and justified with respect to the pathology, imaging task, and intended downstream clinical use.

eess.IV↗

arXiv2024

Can Rule-Based Insights Enhance LLMs for Radiology Report Classification? Introducing the RadPrompt Methodology

Developing imaging models capable of detecting pathologies from chest X-rays can be cost and time-prohibitive for large datasets as it requires supervision to attain state-of-the-art performance. Instead, labels extracted from radiology reports may serve as distant supervision since these are routinely generated as part of clinical practice. Despite their widespread use, current rule-based methods for label extraction rely on extensive rule sets that are limited in their robustness to syntactic variability. To alleviate these limitations, we introduce RadPert, a rule-based system that integrates an uncertainty-aware information schema with a streamlined set of rules, enhancing performance. Additionally, we have developed RadPrompt, a multi-turn prompting strategy that leverages RadPert to bolster the zero-shot predictive capabilities of large language models, achieving a statistically significant improvement in weighted average F1 score over GPT-4 Turbo. Most notably, RadPrompt surpasses both its underlying models, showcasing the synergistic potential of LLMs with rule-based models. We have evaluated our methods on two English Corpora: the MIMIC-CXR gold-standard test set and a gold-standard dataset collected from the Cambridge University Hospitals.

cs.CL↗

arXiv2021

What Makes a Scientific Paper be Accepted for Publication?

Despite peer-reviewing being an essential component of academia since the 1600s, it has repeatedly received criticisms for lack of transparency and consistency. We posit that recent work in machine learning and explainable AI provide tools that enable insights into the decisions from a given peer review process. We start by extracting global explanations in the form of linguistic features that affect the acceptance of a scientific paper for publication on an open peer-review dataset. Second, since such global explanations do not justify causal interpretations, we provide a methodology for detecting confounding effects in natural language in order to generate causal explanations, under assumptions, in the form of lexicons. Our proposed linguistic explanation methodology indicates the following on a case dataset of ICLR submissions: a) the organising committee follows, for the most part, the recommendations of reviewers, and, b) the paper's main characteristics that led to reviewers recommending acceptance for publication are originality, clarity and substance.

cs.CL↗