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Panpan Chen

Publications and source records attributed to Panpan Chen.

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Benchmarking Deep Learning-Based Reconstruction Methods for Photoacoustic Computed Tomography with Clinically Relevant Synthetic Datasets

Deep learning (DL)-based image reconstruction methods for photoacoustic computed tomography (PACT) have developed rapidly in recent years. However, most existing methods have not employed standardized datasets, and their evaluations rely on traditional image quality (IQ) metrics that may lack clinical relevance. The absence of a standardized framework for clinically meaningful IQ assessment hinders fair comparison and raises concerns about the reproducibility and reliability of reported advancements in PACT. A benchmarking framework is proposed that provides open-source, anatomically plausible synthetic datasets and evaluation strategies for DL-based acoustic inversion methods in PACT. The datasets each include over 11,000 two-dimensional (2D) stochastic breast objects with clinically relevant lesions and paired measurements at varying modeling complexity. The evaluation strategies incorporate both traditional and task-based IQ measures to assess fidelity and clinical utility. A preliminary benchmarking study is conducted to demonstrate the framework's utility by comparing DL-based and physics-based reconstruction methods. The benchmarking study demonstrated that the proposed framework enabled comprehensive, quantitative comparisons of reconstruction performance and revealed important limitations in certain DL-based methods. Although they performed well according to traditional IQ measures, they often failed to accurately recover lesions. This highlights the inadequacy of traditional metrics and motivates the need for task-based assessments. The proposed benchmarking framework enables systematic comparisons of DL-based acoustic inversion methods for 2D PACT. By integrating clinically relevant synthetic datasets with rigorous evaluation protocols, it enables reproducible, objective assessments and facilitates method development and system optimization in PACT.

physics.med-ph

Beyond Carleman Linearization of Nonlinear Dynamical System: Insights from a Case Study

Nonlinear dynamical systems are widely encountered in various scientific and engineering fields. Despite significant advances in theoretical understanding, developing complete and integrated frameworks for analyzing and designing these systems remains challenging, which underscores the importance of efficient linearization methods. In this paper, we introduce a general linearization framework with emphasis on Carleman linearization and Carleman-Fourier linearization. A detailed case study on finite-section approximation to the lifted infinite-dimensional dynamical system is provided for the dynamical system with its governing function being a trigonometric polynomial of degree one.

math.DS

Learning a Filtered Backprojection Reconstruction Method for Photoacoustic Computed Tomography with Hemispherical Measurement Geometries

In certain three-dimensional (3D) applications of photoacoustic computed tomography (PACT), including \textit{in vivo} breast imaging, hemispherical measurement apertures that enclose the object within their convex hull are employed for data acquisition. Data acquired with such measurement geometries are referred to as \textit{half-scan} data, as only half of a complete spherical measurement aperture is employed. Although previous studies have demonstrated that half-scan data can uniquely and stably reconstruct the sought-after object, no closed-form reconstruction formula for use with half-scan data has been reported. To address this, a semi-analytic reconstruction method in the form of filtered backprojection (FBP), referred to as the half-scan FBP method, is developed in this work. Because the explicit form of the filtering operation in the half-scan FBP method is not currently known, a learning-based method is proposed to approximate it. The proposed method is systematically investigated by use of virtual imaging studies of 3D breast PACT that employ ensembles of numerical breast phantoms and a physics-based model of the data acquisition process. The method is subsequently applied to experimental data acquired in an \textit{in vivo} breast PACT study. The results confirm that the half-scan FBP method can accurately reconstruct 3D images from half-scan data. Importantly, because the sought-after inverse mapping is well-posed, the reconstruction method remains accurate even when applied to data that differ considerably from those employed to learn the filtering operation.

physics.med-ph

Carleman-Fourier Linearization of Complex Dynamical Systems: Convergence and Explicit Error Bounds

This paper presents a Carleman-Fourier linearization method for nonlinear dynamical systems with periodic vector fields involving multiple fundamental frequencies. By employing Fourier basis functions, the nonlinear dynamical system is transformed into a linear model on an infinite-dimensional space. The proposed approach yields accurate approximations over extended regions around equilibria and for longer time horizons, compared to traditional Carleman linearization with monomials. Additionally, we develop a finite-section approximation for the resulting infinite-dimensional system and provide explicit error bounds that demonstrate exponential convergence to the original system's solution as the truncation length increases. For specific classes of dynamical systems, exponential convergence is achieved across the entire time horizon. The practical significance of these results lies in guiding the selection of suitable truncation lengths for applications such as model predictive control, safety verification through reachability analysis, and efficient quantum computing algorithms. The theoretical findings are validated through illustrative simulations.

math.DS

Which is a better programming assistant? A comparative study between chatgpt and stack overflow

Programmers often seek help from Q\&A websites to resolve issues they encounter during programming. Stack Overflow has been a widely used platform for this purpose for over a decade. Recently, revolutionary AI-powered platforms like ChatGPT have quickly gained popularity among programmers for their efficient and personalized programming assistance via natural language interactions. Both platforms can offer valuable assistance to programmers, but it's unclear which is more effective at enhancing programmer productivity. In our paper, we conducted an exploratory user study to compare the performance of Stack Overflow and ChatGPT in enhancing programmer productivity. Two groups of students with similar programming abilities were instructed to use the two platforms to solve three different types of programming tasks: algorithmic challenges, library usage, and debugging. During the experiments, we measured and compared the quality of code produced and the time taken to complete tasks for the two groups. The results show that, concerning code quality, ChatGPT outperforms Stack Overflow significantly in helping complete algorithmic and library-related tasks, while Stack Overflow is better for debugging tasks. Regarding task completion speed, the ChatGPT group is obviously faster than the Stack Overflow group in the algorithmic challenge, but the two groups have a similar performance in the other two tasks. Additionally, we conducted a post-experiment survey with the participants to understand how the platforms have helped them complete the programming tasks. We analyzed the questionnaires to summarize ChatGPT and Stack Overflow's strengths and weaknesses pointed out by the participants. By comparing these, we identified the reasons behind the two platforms' divergent performances in programming assistance.

cs.SE