arXiv subjects

Pascal Helson

Publications and source records attributed to Pascal Helson.

6 recordsLinked to original sources

arXiv2025

Mean-field analysis of a neural network with stochastic STDP

Analysing biological spiking neural network models with synaptic plasticity has proven to be challenging both theoretically and numerically. In a network with N all-to-all connected neurons, the number of synaptic connections is on the order of $N^2$, making these models computationally demanding. Furthermore, the intricate coupling between neuron and synapse dynamics, along with the heterogeneity generated by plasticity, hinder the use of classic theoretical tools such as mean-field or slow-fast analyses. To address these challenges, we introduce a new variable which we term a typical neuron X. Viewed as a post-synaptic neuron, X is composed of the activity state V , the time since its last spike S, and the empirical distribution $\xi$ of the triplet V , S and W (incoming weight) associated to the pre-synaptic neurons. In particular, we study a stochastic spike-timing-dependent plasticity (STDP) model of connection in a probabilistic Wilson-Cowan spiking neural network model, which features binary neural activity. Taking the large N limit, we obtain from the empirical distribution of the typical neuron a simplified yet accurate representation of the original spiking network. This mean-field limit is a piecewise deterministic Markov process (PDMP) of McKean-Vlasov type, where the typical neuron dynamics depends on its own distribution. We term this analysis McKean-Vlasov mean-field (MKV-MF). Our approach not only reduces computational complexity but also provides insights into the dynamics of this spiking neural network with plasticity. The model obtained is mathematically exact and capable of tracking transient changes. This analysis marks the first exploration of MKV-MF dynamics in a network of spiking neurons interacting with STDP.

physics.bio-ph↗

arXiv2025

Pursuit of biomarkers of brain diseases: Beyond cohort comparisons

Despite the diversity and volume of brain data acquired and advanced AI-based algorithms to analyze them, brain features are rarely used in clinics for diagnosis and prognosis. Here we argue that the field continues to rely on cohort comparisons to seek biomarkers, despite the well-established degeneracy of brain features. Using a thought experiment (Brain Swap), we show that more data and more powerful algorithms will not be sufficient to identify biomarkers of brain diseases. We argue that instead of comparing patient versus healthy controls using single data type, we should use multimodal (e.g. brain activity, neurotransmitters, neuromodulators, brain imaging) and longitudinal brain data to guide the grouping before defining multidimensional biomarkers for brain diseases.

q-bio.NC↗

arXiv2025

Renormalization group analysis of noisy neural field

Neurons in the brain show great diversity in their individual properties and their connections to other neurons. To develop an understanding of how neuronal diversity contributes to brain dynamics and function at large scales we start with a linearized version of the Wilson-Kowan model and introduce a random anisotropy to inter-neuron connection. The resultant model is Edwards-Wilkinson model with a random anisotropic term. Averaging over the quenched randomness with the replica method we obtain a bi-quadratic nonlinearity. We use Wilsonian dynamic renormalization group to analyze this model. We find that, up to one loop order, for dimensions higher than two, the effect of the noise is to change dynamic exponent from two to one.

cond-mat.dis-nn↗

arXiv2023

Structural constraints on the emergence of oscillations in multi-population neural networks

Oscillations arise in many real-world systems and are associated with both functional and dysfunctional states. Whether a network can oscillate can be estimated if we know the strength of interaction between nodes. But in real-world networks (in particular in biological networks) it is usually not possible to know the exact connection weights. Therefore, it is important to determine the structural properties of a network necessary to generate oscillations. Here, we provide a proof that uses dynamical system theory to prove that an odd number of inhibitory nodes and strong enough connections are necessary to generate oscillations in a single cycle threshold-linear network. We illustrate these analytical results in a biologically plausible network with either firing-rate based or spiking neurons. Our work provides structural properties necessary to generate oscillations in a network. We use this knowledge to reconcile recent experimental findings about oscillations in basal ganglia with classical findings.

q-bio.NC↗

arXiv2019

A Mathematical Analysis of Memory Lifetime in a simple Network Model of Memory

We study the learning of an external signal by a neural network and the time to forget it when this network is submitted to noise. The presentation of an external stimulus to the recurrent network of binary neurons may change the state of the synapses. Multiple presentations of a unique signal leads to its learning. Then, during the forgetting time, the presentation of other signals (noise) may also modify the synaptic weights. We construct an estimator of the initial signal thanks to the synaptic currents and define by this way a probability of error. In our model, these synaptic currents evolve as Markov chains. We study the dynamics of these Markov chains and obtain a lower bound on the number of external stimuli that the network can receive before the initial signal is considered as forgotten (probability of error above a given threshold). Our results hold for finite size networks as well as in the large size asymptotic. Our results are based on a finite time analysis rather than large time asymptotic. We finally present numerical illustrations of our results.

math.PR↗

arXiv2017

A new stochastic STDP Rule in a neural Network Model

Thought to be responsible for memory, synaptic plasticity has been widely studied in the past few decades. One example of plasticity models is the popular Spike Timing Dependent Plasticity (STDP). The huge litterature of STDP models are mainly based deterministic rules whereas the biological mechanisms involved are mainly stochastic ones. Moreover, there exist only few mathematical studies on plasticity taking into account the precise spikes timings. In this article, we aim at proposing a new stochastic STDP rule with discrete synaptic weights which allows a mathematical analysis of the full network dynamics under the hypothesis of separation of timescales. This model attempts to answer the need for understanding the interplay between the weights dynamics and the neurons ones.

math.PR↗