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Pau Closas

Publications and source records attributed to Pau Closas.

40 records · Page 3Linked to original sources

Importance Gaussian Quadrature

Importance sampling (IS) and numerical integration methods are usually employed for approximating moments of complicated target distributions. In its basic procedure, the IS methodology randomly draws samples from a proposal distribution and weights them accordingly, accounting for the mismatch between the target and proposal. In this work, we present a general framework of numerical integration techniques inspired by the IS methodology. The framework can also be seen as an incorporation of deterministic rules into IS methods, reducing the error of the estimators by several orders of magnitude in several problems of interest. The proposed approach extends the range of applicability of the Gaussian quadrature rules. For instance, the IS perspective allows us to use Gauss-Hermite rules in problems where the integrand is not involving a Gaussian distribution, and even more, when the integrand can only be evaluated up to a normalizing constant, as it is usually the case in Bayesian inference. The novel perspective makes use of recent advances on the multiple IS (MIS) and adaptive (AIS) literatures, and incorporates it to a wider numerical integration framework that combines several numerical integration rules that can be iteratively adapted. We analyze the convergence of the algorithms and provide some representative examples showing the superiority of the proposed approach in terms of performance.

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Kalman Filtering and Expectation Maximization for Multitemporal Spectral Unmixing

The recent evolution of hyperspectral imaging technology and the proliferation of new emerging applications presses for the processing of multiple temporal hyperspectral images. In this work, we propose a novel spectral unmixing (SU) strategy using physically motivated parametric endmember representations to account for temporal spectral variability. By representing the multitemporal mixing process using a state-space formulation, we are able to exploit the Bayesian filtering machinery to estimate the endmember variability coefficients. Moreover, by assuming that the temporal variability of the abundances is small over short intervals, an efficient implementation of the expectation maximization (EM) algorithm is employed to estimate the abundances and the other model parameters. Simulation results indicate that the proposed strategy outperforms state-of-the-art multitemporal SU algorithms.

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Mean Square Error bounds for parameter estimation under model misspecification

In parameter estimation, assumptions about the model are typically considered which allow us to build optimal estimation methods under many statistical senses. However, it is usually the case where such models are inaccurately known or not capturing the complexity of the observed phenomenon. A natural question arises to whether we can find fundamental estimation bounds under model mismatches. This paper derives a general bound on the mean square error (MSE) following the Ziv-Zakai methodology for the widely used additive Gaussian model. The general result accounts for erroneous functionals, hyperparameters, and distributions differing from the Gaussian. The result is then particularized to gain some insight into specific problems and some illustrative examples demonstrate the predictive capabilities of the bound.

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Sequential estimation of intrinsic activity and synaptic input in single neurons by particle filtering with optimal importance density

This paper deals with the problem of inferring the signals and parameters that cause neural activity to occur. The ultimate challenge being to unveil brain's connectivity, here we focus on a microscopic vision of the problem, where single neurons (potentially connected to a network of peers) are at the core of our study. The sole observation available are noisy, sampled voltage traces obtained from intracellular recordings. We design algorithms and inference methods using the tools provided by stochastic filtering, that allow a probabilistic interpretation and treatment of the problem. Using particle filtering we are able to reconstruct traces of voltages and estimate the time course of auxiliary variables. By extending the algorithm, through PMCMC methodology, we are able to estimate hidden physiological parameters as well, like intrinsic conductances or reversal potentials. Last, but not least, the method is applied to estimate synaptic conductances arriving at a target cell, thus reconstructing the synaptic excitatory/inhibitory input traces. Notably, these estimations have a bound-achieving performance even in spiking regimes.

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