arXiv subjects

Pearson W. Miller

Publications and source records attributed to Pearson W. Miller.

3 recordsLinked to original sources

arXiv2026

Optimal control of symmetry-breaking dynamics near criticality

We study the problem of optimal control for dynamical systems near a pitchfork bifurcation, motivated by the role of external cues in guiding symmetry-breaking transitions in cell-fate selection and other natural processes. Using an asymptotic expansion of the optimality conditions obtained from the Pontryagin maximum principle, the leading-order optimal control law for a general n-dimensional system is examined across three dynamical regimes distinguished by scaling of control strength with respect to the distance from criticality. While in the strong control limit the results reduce to known approximations from linear-quadratic control, we derive generalized amplitude equations for the co-evolution of state and costate variables describing the optimized trajectory in the weak and intermediate control regimes. These control normal forms are validated against numerical solutions of the full optimal control problem for a canonical model of a bistable biochemical switch. The bifurcation structure of the optimal control problem is analyzed in the weak control regime. Finally, we demonstrate the construction of asymptotic solutions in the long time limit in this regime using boundary-layer methods.

math.OC↗

arXiv2022

Generation and motion of interfaces in a mass-conserving reaction-diffusion system

Reaction-diffusion models with nonlocal constraints naturally arise as limiting cases of coupled bulk-surface models of intracellular signalling. In this paper, a minimal, mass-conserving model of cell-polarization on a curved membrane is analyzed in the limit of slow surface diffusion. Using the tools of formal asymptotics and calculus of variations, we study the characteristic wave-pinning behavior of this system on three dynamical timescales. On the short timescale, generation of an interface separating high- and low-concentration domains is established under suitable conditions. Intermediate timescale dynamics is shown to lead to a uniform growth or shrinking of these domains to sizes which are fixed by global parameters. Finally, the long time dynamics reduces to area-preserving geodesic curvature flow that may lead to multi-interface steady state solutions. These results provide a foundation for studying cell polarization and related phenomena in biologically relevant geometries.

nlin.PS↗

arXiv2018

Geometry of wave propagation on active deformable surfaces

Fundamental biological and biomimetic processes, from tissue morphogenesis to soft robotics, rely on the propagation of chemical and mechanical surface waves to signal and coordinate active force generation. The complex interplay between surface geometry and contraction wave dynamics remains poorly understood, but will be essential for the future design of chemically-driven soft robots and active materials. Here, we couple prototypical chemical wave and reaction-diffusion models to non-Euclidean shell mechanics to identify and characterize generic features of chemo-mechanical wave propagation on active deformable surfaces. Our theoretical framework is validated against recent data from contractile wave measurements on ascidian and starfish oocytes, producing good quantitative agreement in both cases. The theory is then applied to illustrate how geometry and preexisting discrete symmetries can be utilized to focus active elastic surface waves. We highlight the practical potential of chemo-mechanical coupling by demonstrating spontaneous wave-induced locomotion of elastic shells of various geometries. Altogether, our results show how geometry, elasticity and chemical signaling can be harnessed to construct dynamically adaptable, autonomously moving mechanical surface wave guides.

cond-mat.soft↗