arXiv subjects

Pedja Klasnja

Publications and source records attributed to Pedja Klasnja.

4 recordsLinked to original sources

arXiv2026

A Diffusion-Model Subpopulation Digital Twin for Mobile Health Deployment: A Case Study on the HeartSteps Intervention

Mobile-health interventions increasingly use online learning and decision making algorithms to personalize when to nudge users toward healthier behavior, but a poorly designed algorithm can burden and disengage participants. New algorithm design decisions should therefore be vetted against realistic simulated users before each real-life deployment. We propose a method to develop ``JITAI-Twins'': digital twins of a target subpopulation for comparing candidate online algorithms before a just-in-time adaptive intervention (JITAI) deployment. The method builds on a conditional time-series diffusion model that is temporally consistent (future actions do not affect the generated past), and it supports repeated updating from three sources of information, in three steps: pre-training on a large observational dataset, fine-tuning on small prior intervention deployments in related populations, and inference-time calibration to the next target population from domain-scientist expertise. We validate the twin at each pre-deployment stage of the long-running HeartSteps series (v2 through v4) of physical-activity suggestion intervention deployments, treating each successive deployment as an upcoming study. The proposed method reproduces the target subpopulation's temporal and between-participant structure better than simpler simulators. These results suggest that our twin can be used to simulate a target deployment before it runs, the prerequisite for testing and informing online algorithm design decisions.

cs.LG↗

arXiv2025

Evaluation of the HeartSteps Online Sampling Algorithm

Micro-randomized trials (MRTs), which sequentially randomize participants at multiple decision times, have gained prominence in digital intervention development. These sequential randomizations are often subject to certain constraints. In the MRT called HeartSteps V2V3, where an intervention is designed to interrupt sedentary behavior, two core design constraints need to be managed: an average of 1.5 interventions across days and the uniform delivery of interventions across decision times. Meeting both constraints, especially when the times allowed for randomization are not determined beforehand, is challenging. An online algorithm was implemented to meet these constraints in the HeartSteps V2V3 MRT. We present a case study using data from the HeartSteps V2V3 MRT, where we select appropriate metrics, discuss issues in making an accurate evaluation, and assess the algorithm's performance. Our evaluation shows that the algorithm performed well in meeting the two constraints. Furthermore, we identify areas for improvement and provide recommendations for designers of MRTs that need to satisfy these core design constraints.

stat.AP↗

arXiv2022

BayesLDM: A Domain-Specific Language for Probabilistic Modeling of Longitudinal Data

In this paper we present BayesLDM, a system for Bayesian longitudinal data modeling consisting of a high-level modeling language with specific features for modeling complex multivariate time series data coupled with a compiler that can produce optimized probabilistic program code for performing inference in the specified model. BayesLDM supports modeling of Bayesian network models with a specific focus on the efficient, declarative specification of dynamic Bayesian Networks (DBNs). The BayesLDM compiler combines a model specification with inspection of available data and outputs code for performing Bayesian inference for unknown model parameters while simultaneously handling missing data. These capabilities have the potential to significantly accelerate iterative modeling workflows in domains that involve the analysis of complex longitudinal data by abstracting away the process of producing computationally efficient probabilistic inference code. We describe the BayesLDM system components, evaluate the efficiency of representation and inference optimizations and provide an illustrative example of the application of the system to analyzing heterogeneous and partially observed mobile health data.

cs.LG↗

arXiv2021

Online structural kernel selection for mobile health

Motivated by the need for efficient and personalized learning in mobile health, we investigate the problem of online kernel selection for Gaussian Process regression in the multi-task setting. We propose a novel generative process on the kernel composition for this purpose. Our method demonstrates that trajectories of kernel evolutions can be transferred between users to improve learning and that the kernels themselves are meaningful for an mHealth prediction goal.

cs.LG↗