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Pedro A. Valdés-Sosa

Publications and source records attributed to Pedro A. Valdés-Sosa.

4 recordsLinked to original sources

EEG Foundation Challenge: From Cross-Task to Cross-Subject EEG Decoding

Current electroencephalogram (EEG) decoding models are typically trained on small numbers of subjects performing a single task. Here, we introduce a large-scale, code-submission-based competition comprising two challenges. First, the Transfer Challenge asks participants to build and test a model that can zero-shot decode new tasks and new subjects from their EEG data. Second, the Psychopathology factor prediction Challenge asks participants to infer subject measures of mental health from EEG data. For this, we use an unprecedented, multi-terabyte dataset of high-density EEG signals (128 channels) recorded from over 3,000 child to young adult subjects engaged in multiple active and passive tasks. We provide several tunable neural network baselines for each of these two challenges, including a simple network and demographic-based regression models. Developing models that generalise across tasks and individuals will pave the way for ML network architectures capable of adapting to EEG data collected from diverse tasks and individuals. Similarly, predicting mental health-relevant personality trait values from EEG might identify objective biomarkers useful for clinical diagnosis and design of personalised treatment for psychological conditions. Ultimately, the advances spurred by this challenge could contribute to the development of computational psychiatry and useful neurotechnology, and contribute to breakthroughs in both fundamental neuroscience and applied clinical research.

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FKreg: A MATLAB toolbox for fast Multivariate Kernel Regression

Kernel smooth is the most fundamental technique for data density and regression estimation. However, time-consuming is the biggest obstacle for the application that the direct evaluation of kernel smooth for $N$ samples needs ${O}\left( {{N}^{2}} \right)$ operations. People have developed fast smooth algorithms using the idea of binning with FFT. Unfortunately, the accuracy is not controllable, and the implementation for multivariable and its bandwidth selection for the fast method is not available. Hence, we introduce a new MATLAB toolbox for fast multivariate kernel regression with the idea of non-uniform FFT (NUFFT), which implemented the algorithm for $M$ gridding points with ${O}\left( N+M\log M \right)$ complexity and accuracy controllability. The bandwidth selection problem utilizes the Fast Monte-Carlo algorithm to estimate the degree of freedom (DF), saving enormous cross-validation time even better when data share the same grid space for multiple regression. Up to now, this is the first toolbox for fast-binning high-dimensional kernel regression. Moreover, the estimation for local polynomial regression, the conditional variance for the heteroscedastic model, and the complex-valued datasets are also implemented in this toolbox. The performance is demonstrated with simulations and an application on the quantitive EEG.

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Multiple penalized least squares and sign constraints with modified Newton-Raphson algorithms: application to EEG source imaging

Multiple penalized least squares (MPLS) models are a flexible approach to find adaptive least squares solutions required to be simultaneously sparse and smooth. This is particularly important when addressing real-life inverse problems where there is no ground truth available, such as electrophysiological source imaging. In this work we formalize a modified Newton-Raphson (MNR) algorithm to estimate general MPLS models and propose its extension to perform efficient optimization over the active set of selected features (AMNR). This algorithm can be used to minimize continuously differentiable objective functions with multiple restrictions, including sign constraints. We show that these algorithms provide solutions with acceptable reconstruction in simulated scenarios that do not cope with model assumptions, and for low n/p ratios. We then use both algorithms for estimating different electroencephalography (EEG) inverse models with multiple penalties. We also show how the AMNR allows us to estimate new models in the EEG inverse problem context, such as nonnegative versions of Smooth Garrote and Smooth LASSO. Synthetic data were used for a comparison between solutions obtained using the two algorithms proposed here and the least angle regression (LARS) algorithm, according to well-known quality measures. A visual event-related EEG from healthy young subjects and a resting-state EEG study on the relationship between cognitive ageing and walking speed decline in active elders, were used to illustrate the usefulness of the proposed methods in the analysis of real experimental data.

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Empirical bayes formulation of the elastic net and mixed-norm models: application to the eeg inverse problem

The estimation of EEG generating sources constitutes an Inverse Problem (IP) in Neuroscience. This is an ill-posed problem, due to the non-uniqueness of the solution, and many kinds of prior information have been used to constrain it. A combination of smoothness (L2 norm-based) and sparseness (L1 norm-based) constraints is a flexible approach that have been pursued by important examples such as the Elastic Net (ENET) and mixed-norm (MXN) models. The former is used to find solutions with a small number of smooth non-zero patches, while the latter imposes sparseness and smoothness simultaneously along different dimensions of the spatio-temporal matrix solutions. Both models have been addressed within the penalized regression approach, where the regularization parameters are selected heuristically, leading usually to non-optimal solutions. The existing Bayesian formulation of ENET allows hyperparameter learning, but using computationally intensive Monte Carlo/Expectation Maximization methods. In this work we attempt to solve the EEG IP using a Bayesian framework for models based on mixtures of L1/L2 norms penalization functions (Laplace/Normal priors) such as ENET and MXN. We propose a Sparse Bayesian Learning algorithm based on combining the Empirical Bayes and the iterative coordinate descent procedures to estimate both the parameters and hyperparameters. Using simple but realistic simulations we found that our methods are able to recover complicated source setups more accurately and with a more robust variable selection than the ENET and LASSO solutions using classical algorithms. We also solve the EEG IP using data coming from a visual attention experiment, finding more interpretable neurophysiological patterns with our methods, as compared with other known methods such as LORETA, ENET and LASSO FUSION using the classical regularization approach.

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