arXiv subjects

Pengfei Jin

Publications and source records attributed to Pengfei Jin.

At least 19 recordsLinked to original sources

arXiv2026

Coronary Mask Guided Registration for Continuous Time 4D Cardiac CT Dataset Construction

Objective: Clinical cardiac CT multiphase reconstructions generally provide acceptable image quality in end-diastole (ED) or end-systole (ES) phases, but in other phases may exhibit motion artifacts, especially in the right coronary artery (RCA). This limits ground-truth availability in 4D cardiac CT imaging research. We aim to construct a 4D cardiac CT dataset that is generally suitable to serve as pseudo ground truth. Methods: We propose Coronary Mask Guided Registration (CMGR) to produce a motion-preserved, artifact-reduced, and continuous-time 4D cardiac CT sequence from the clinical multiphase reconstruction of each patient. For artifact reduction, CMGR uses the ED or ES phase as the reference phase and warps the reference volume with deformation fields to produce the sequence. For motion preservation, CMGR registers the reference phase to each non-reference phase of the multiphase reconstruction. To capture the motion of both the RCA and other cardiac structures in each registration, CMGR regularizes RCA masks and incorporates them into image-domain registration. Time-continuity is achieved by interpolating the deformation fields for non-reference phases to arbitrary times. Results: CMGR outperformed representative image-domain registration methods in capturing RCA motion and providing reasonable RCA shape, and showed competitive performance in capturing whole-heart motion. Additionally, CMGR reduced motion artifacts from clinical multiphase reconstructions, and intermediate CMGR frames generally provided plausible transitions between discrete cardiac phases. Conclusion: CMGR provides an effective approach for constructing continuous-time 4D cardiac CT datasets. Significance: The dataset can be used in system design simulations and in reconstruction algorithm development, thereby facilitating advances in cardiac CT imaging.

eess.IV↗

arXiv2026

Measurement Geometry and Design for Trustworthy Generative Inverse Problems

Generative models are increasingly used as priors for inverse problems, but their ability to produce realistic images creates a basic trust problem: a plausible reconstruction may be supported by the measurements, or it may be filled in by the prior along unobserved directions. This distinction is especially important in medical imaging, where acquisition operators are designed under scan-time, dose, and calibration constraints. We study generative inverse problems from a measurement-geometry perspective. The central question is whether a fixed measurement operator can distinguish nearby images that are plausible under the generative prior, and whether this relationship can guide better measurements. We introduce a local measurement-manifold compatibility measure that quantifies how well the operator observes prior-relevant tangent directions. Under local regularity assumptions, we prove that this quantity controls the stable part of the reconstruction error, while the generative prior controls off-manifold drift. This worst-direction certificate motivates practical fixed and sequential acquisition rules based on overall local volume preservation, including a posterior-cloud design that adapts measurements at test time without training a sampling policy. Across row-sampling, tomographic, and MR acquisition settings, the proposed scores predict failure modes, explain measurement-induced hallucinations, and guide better sampling. In fastMRI Cartesian sampling, posterior-cloud measurement design improves over strong non-learned ACS-preserving baselines, including variable-density and Poisson-like masks.

cs.LG↗

arXiv2026

Hallucination-Aware Diffusion Sampling for Inverse Problems via Robust Prior Updates

Diffusion-based inverse problem solvers can produce realistic reconstructions, but realism alone does not ensure that the recovered details are supported by the measurement. We study this failure as measurement-conditioned hallucination: visually meaningful content that is either implausible or inconsistent with the measured instance. Our analysis separates Bayes-rule-based diffusion inverse solvers into a prior update and a measurement-conditioning step, showing that hallucinated content can enter through the prior-side proposal before the measurement correction is applied. Motivated by this view, we propose Robust Prior Update (RPU), a solver-level module that probes the local stability of the diffusion prior update, re-anchors the resulting displacement at the current iterate, and leaves the measurement update unchanged. We instantiate RPU in DPS and evaluate it on FFHQ and ImageNet inverse problems using automatic metrics and human faithfulness studies. On FFHQ, RPU improves PSNR and LPIPS over DPS across box inpainting, Gaussian deblurring, and motion deblurring. In human judgments, RPU receives 91.9% of blind non-tie majority preferences and 91.1% of ground-truth-assisted non-tie preferences on FFHQ box inpainting, while the ImageNet Gaussian reader study is tie-heavy but favors RPU among non-tie cases. These results support a targeted claim: robustifying the prior update can improve instance faithfulness in diffusion inverse solvers, especially when the prior shapes weakly constrained content.

cs.CV↗

arXiv2026

LiFT: Lifted Inter-slice Feature Trajectories for 3D Image Generation from 2D Generators

High-resolution 3D medical image generation remains challenging because fully volumetric models are computationally expensive, while efficient 2D slice generators often fail to preserve anatomical consistency across the third dimension. We propose LiFT, a framework for Lifted inter-slice Feature Trajectories that factorizes 3D volume synthesis into per-slice image generation and inter-slice trajectory learning. Rather than modeling the volumetric distribution end-to-end, LiFT treats a volume as an ordered trajectory in feature space, capturing how anatomical structures appear, transform, and disappear across depth. A tri-planar drifting loss aligns the trajectory of generated slices with the trajectories of real volumes, enabling distributional learning over inter-slice progressions in unconditional generation; in paired translation, a bidirectional $z$-context mixer trained against the registered target supplies through-plane coherence while preserving per-slice fidelity. We evaluate LiFT on BraTS 2023 (unconditional and missing-modality MR) and SynthRAD2023 (MR-to-CT). Across these settings, LiFT preserves per-slice quality, approaches the reported cWDM missing-MR reconstruction quality at $\sim$$135\times$ lower inference cost (without formal equivalence testing), and improves through-plane coherence on MR-to-CT relative to a no-mapper ablation, demonstrating that lightweight inter-slice trajectory learning is a viable route to high-resolution 3D medical synthesis.

cs.CV↗

arXiv2026

DuetFair: Coupling Inter- and Intra-Subgroup Robustness for Fair Medical Image Segmentation

Medical image segmentation models can perform unevenly across subgroups. Most existing fairness methods focus on improving average subgroup performance, implicitly treating each subgroup as internally homogeneous. However, this can hide difficult cases within a subgroup, where high-loss samples are obscured by the subgroup mean. We call this problem \textbf{intra-group hidden failure}. To solve this, we propose \textbf{DuetFair} mechanism, a dual-axis fairness framework that jointly considers inter-subgroup adaptation and intra-subgroup robustness. Based on DuetFair, we introduce \textbf{FairDRO}, which combines distribution-aware mixture-of-experts (dMoE) with subgroup-conditioned distributionally robust optimization (DRO) loss aggregation. This design allows the model to adapt across subgroups while also reducing hidden failures within each subgroup. We evaluate FairDRO on three medical image segmentation benchmarks with varying degrees of within-group heterogeneity. FairDRO achieves the best equity-scaled performance on Harvard-FairSeg and improves worst-case subgroup performance on HAM10000 under both age- and race-based grouping schemes. On the 3D radiotherapy target cohort, FairDRO further improves worst-group Dice by 3.5 points ($\uparrow 6.0\%$) under the tumor-stage grouping and by 4.1 points ($\uparrow 7.4\%$) under the institution grouping over the strongest baseline.

cs.CV↗

arXiv2026

Local Intrinsic Dimension Unveils Hallucinations in Diffusion Models

Diffusion models are prone to generating structural hallucinations - samples that match the statistical properties of the training data yet defy underlying structural rules, resulting in anomalies like hands with more than five fingers. Recent research studied this failure mode from several viewpoints, offering partial explanations to their occurrence, such as mode interpolation. In this work, we propose a complementary perspective that treats hallucinations as instabilities on the model-induced manifold. We begin by showing that a hallucination filter based on such instabilities matches or exceeds the performance of the recently proposed temporal one. By tracing the source of these instabilities, we identify local intrinsic dimension (LID) as their primary driver and propose Intrinsic Quenching (IQ), a direct corrective mechanism that deflates it to alleviate hallucinations. IQ consistently outperforms standard hallucination reduction baselines across a wide array of benchmarks and offers a highly promising solution for enforcing anatomical consistency in downstream medical imaging tasks.

cs.CV↗

arXiv2026

A Pilot Kinematic Study on the Forehand Reverse Flick: Feasibility of a Novel Short Return Technique in Table Tennis

Background Following changes in table tennis ball materials, offensive returns have become more important for initiating sustained topspin offense. However, using the backhand flick (BF) to return forehand short balls often increases the difficulty of recovery and continuity, revealing a technical gap. This study preliminarily verified a novel forehand short return technique, the forehand reverse flick (FRF), and analyzed its similarities and differences with the BF. Methods Four elite athletes completed seven consecutive days of FRF specific training. Infrared motion capture and ultra-high-speed cameras were used to collect data on racket kinematics, movement duration, and ball performance. Results The success rate of the FRF increased steadily, reaching 86%. Racket trajectories of the two techniques were highly similar along the X (r = 1) and Y (r = 0.99) axes but differed along the Z (r = -0.04) axis. Racket and ball velocities were comparable between techniques, whereas the FRF showed lower resultant acceleration (approximately 265.57 m/s) and required about 0.03 s more for movement duration. Ball velocity was comparable between techniques, for the ball spin, the FRF generated lower spin (approximately 76.61 r/s) about 64% of the BF value (approximately 120.13 r/s). The highest participant mean spin rate reached 93 r/s, about 77% of the BF mean. Conclusion Overall, the FRF was found to have favorable learnability and training value, with potential for further optimization and competitive application.

physics.med-ph↗

arXiv2025

Projection Embedded Diffusion Bridge for CT Reconstruction from Incomplete Data

Reconstructing CT images from incomplete projection data remains challenging due to the ill-posed nature of the problem. Diffusion bridge models have recently shown promise in restoring clean images from their corresponding Filtered Back Projection (FBP) reconstructions, but incorporating data consistency into these models remains largely underexplored. Incorporating data consistency can improve reconstruction fidelity by aligning the reconstructed image with the observed projection data, and can enhance detail recovery by integrating structural information contained in the projections. In this work, we propose the Projection Embedded Diffusion Bridge (PEDB). PEDB introduces a novel reverse stochastic differential equation (SDE) to sample from the distribution of clean images conditioned on both the FBP reconstruction and the incomplete projection data. By explicitly conditioning on the projection data in sampling the clean images, PEDB naturally incorporates data consistency. We embed the projection data into the score function of the reverse SDE. Under certain assumptions, we derive a tractable expression for the posterior score. In addition, we introduce a free parameter to control the level of stochasticity in the reverse process. We also design a discretization scheme for the reverse SDE to mitigate discretization error. Extensive experiments demonstrate that PEDB achieves strong performance in CT reconstruction from three types of incomplete data, including sparse-view, limited-angle, and truncated projections. For each of these types, PEDB outperforms evaluated state-of-the-art diffusion bridge models across standard, noisy, and domain-shift evaluations.

cs.CV↗

arXiv2025

PIRF: Physics-Informed Reward Fine-Tuning for Diffusion Models

Diffusion models have demonstrated strong generative capabilities across scientific domains, but often produce outputs that violate physical laws. We propose a new perspective by framing physics-informed generation as a sparse reward optimization problem, where adherence to physical constraints is treated as a reward signal. This formulation unifies prior approaches under a reward-based paradigm and reveals a shared bottleneck: reliance on diffusion posterior sampling (DPS)-style value function approximations, which introduce non-negligible errors and lead to training instability and inference inefficiency. To overcome this, we introduce Physics-Informed Reward Fine-tuning (PIRF), a method that bypasses value approximation by computing trajectory-level rewards and backpropagating their gradients directly. However, a naive implementation suffers from low sample efficiency and compromised data fidelity. PIRF mitigates these issues through two key strategies: (1) a layer-wise truncated backpropagation method that leverages the spatiotemporally localized nature of physics-based rewards, and (2) a weight-based regularization scheme that improves efficiency over traditional distillation-based methods. Across five PDE benchmarks, PIRF consistently achieves superior physical enforcement under efficient sampling regimes, highlighting the potential of reward fine-tuning for advancing scientific generative modeling.

cs.LG↗

arXiv2025

RODS: Robust Optimization Inspired Diffusion Sampling for Detecting and Reducing Hallucination in Generative Models

Diffusion models have achieved state-of-the-art performance in generative modeling, yet their sampling procedures remain vulnerable to hallucinations-often stemming from inaccuracies in score approximation. In this work, we reinterpret diffusion sampling through the lens of optimization and introduce RODS (Robust Optimization-inspired Diffusion Sampler), a novel method that detects and corrects high-risk sampling steps using geometric cues from the loss landscape. RODS enforces smoother sampling trajectories and adaptively adjusts perturbations, reducing hallucinations without retraining and at minimal additional inference cost. Experiments on AFHQv2, FFHQ, and 11k-hands demonstrate that RODS maintains comparable image quality and preserves generation diversity. More importantly, it improves both sampling fidelity and robustness, detecting over 70% of hallucinated samples and correcting more than 25%, all while avoiding the introduction of new artifacts. We release our code at https://github.com/Yiqi-Verna-Tian/RODS.

cs.CV↗

arXiv2025

System-Embedded Diffusion Bridge Models

Solving inverse problems -- recovering signals from incomplete or noisy measurements -- is fundamental in science and engineering. Score-based generative models (SGMs) have recently emerged as a powerful framework for this task. Two main paradigms have formed: unsupervised approaches that adapt pretrained generative models to inverse problems, and supervised bridge methods that train stochastic processes conditioned on paired clean and corrupted data. While the former typically assume knowledge of the measurement model, the latter have largely overlooked this structural information. We introduce System embedded Diffusion Bridge Models (SDBs), a new class of supervised bridge methods that explicitly embed the known linear measurement system into the coefficients of a matrix-valued SDE. This principled integration yields consistent improvements across diverse linear inverse problems and demonstrates robust generalization under system misspecification between training and deployment, offering a promising solution to real-world applications.

cs.LG↗

arXiv2025

Cascaded 3D Diffusion Models for Whole-body 3D 18-F FDG PET/CT synthesis from Demographics

We propose a cascaded 3D diffusion model framework to synthesize high-fidelity 3D PET/CT volumes directly from demographic variables, addressing the growing need for realistic digital twins in oncologic imaging, virtual trials, and AI-driven data augmentation. Unlike deterministic phantoms, which rely on predefined anatomical and metabolic templates, our method employs a two-stage generative process. An initial score-based diffusion model synthesizes low-resolution PET/CT volumes from demographic variables alone, providing global anatomical structures and approximate metabolic activity. This is followed by a super-resolution residual diffusion model that refines spatial resolution. Our framework was trained on 18-F FDG PET/CT scans from the AutoPET dataset and evaluated using organ-wise volume and standardized uptake value (SUV) distributions, comparing synthetic and real data between demographic subgroups. The organ-wise comparison demonstrated strong concordance between synthetic and real images. In particular, most deviations in metabolic uptake values remained within 3-5% of the ground truth in subgroup analysis. These findings highlight the potential of cascaded 3D diffusion models to generate anatomically and metabolically accurate PET/CT images, offering a robust alternative to traditional phantoms and enabling scalable, population-informed synthetic imaging for clinical and research applications.

eess.IV↗

arXiv2025

Surf2CT: Cascaded 3D Flow Matching Models for Torso 3D CT Synthesis from Skin Surface

We present Surf2CT, a novel cascaded flow matching framework that synthesizes full 3D computed tomography (CT) volumes of the human torso from external surface scans and simple demographic data (age, sex, height, weight). This is the first approach capable of generating realistic volumetric internal anatomy images solely based on external body shape and demographics, without any internal imaging. Surf2CT proceeds through three sequential stages: (1) Surface Completion, reconstructing a complete signed distance function (SDF) from partial torso scans using conditional 3D flow matching; (2) Coarse CT Synthesis, generating a low-resolution CT volume from the completed SDF and demographic information; and (3) CT Super-Resolution, refining the coarse volume into a high-resolution CT via a patch-wise conditional flow model. Each stage utilizes a 3D-adapted EDM2 backbone trained via flow matching. We trained our model on a combined dataset of 3,198 torso CT scans (approximately 1.13 million axial slices) sourced from Massachusetts General Hospital (MGH) and the AutoPET challenge. Evaluation on 700 paired torso surface-CT cases demonstrated strong anatomical fidelity: organ volumes exhibited small mean percentage differences (range from -11.1% to 4.4%), and muscle/fat body composition metrics matched ground truth with strong correlation (range from 0.67 to 0.96). Lung localization had minimal bias (mean difference -2.5 mm), and surface completion significantly improved metrics (Chamfer distance: from 521.8 mm to 2.7 mm; Intersection-over-Union: from 0.87 to 0.98). Surf2CT establishes a new paradigm for non-invasive internal anatomical imaging using only external data, opening opportunities for home-based healthcare, preventive medicine, and personalized clinical assessments without the risks associated with conventional imaging techniques.

eess.IV↗

arXiv2025

OWT: A Foundational Organ-Wise Tokenization Framework for Medical Imaging

Recent advances in representation learning often rely on holistic embeddings that entangle multiple semantic components, limiting interpretability and generalization. These issues are especially critical in medical imaging, where downstream tasks depend on anatomically interpretable features. To address these limitations, we propose an Organ-Wise Tokenization (OWT) framework with a Token Group-based Reconstruction (TGR) training paradigm. Unlike conventional approaches, OWT explicitly disentangles an image into separable token groups, each corresponding to a distinct organ or semantic entity. Our design ensures each token group encapsulates organ-specific information, boosting interpretability, generalization, and efficiency while enabling fine-grained control for targeted clinical applications. Experiments on CT and MRI datasets demonstrate OWT's power: it not only achieves strong performance on standard tasks like image reconstruction and segmentation, but also unlocks novel, high-impact clinical capabilities including organ-specific tumor identification, organ-level retrieval and semantic-level generation, without requiring any additional training. These findings underscore the potential of OWT as a foundational framework for semantically disentangled representation learning, offering broad scalability and a new perspective on how representations can be leveraged.

cs.CV↗

arXiv2025

MAST-Pro: Dynamic Mixture-of-Experts for Adaptive Segmentation of Pan-Tumors with Knowledge-Driven Prompts

Accurate tumor segmentation is crucial for cancer diagnosis and treatment. While foundation models have advanced general-purpose segmentation, existing methods still struggle with: (1) limited incorporation of medical priors, (2) imbalance between generic and tumor-specific features, and (3) high computational costs for clinical adaptation. To address these challenges, we propose MAST-Pro (Mixture-of-experts for Adaptive Segmentation of pan-Tumors with knowledge-driven Prompts), a novel framework that integrates dynamic Mixture-of-Experts (D-MoE) and knowledge-driven prompts for pan-tumor segmentation. Specifically, text and anatomical prompts provide domain-specific priors, guiding tumor representation learning, while D-MoE dynamically selects experts to balance generic and tumor-specific feature learning, improving segmentation accuracy across diverse tumor types. To enhance efficiency, we employ Parameter-Efficient Fine-Tuning (PEFT), optimizing MAST-Pro with significantly reduced computational overhead. Experiments on multi-anatomical tumor datasets demonstrate that MAST-Pro outperforms state-of-the-art approaches, achieving up to a 5.20% improvement in average DSC while reducing trainable parameters by 91.04%, without compromising accuracy.

cs.CV↗

arXiv2025

Prediction of Frozen Region Growth in Kidney Cryoablation Intervention Using a 3D Flow-Matching Model

This study presents a 3D flow-matching model designed to predict the progression of the frozen region (iceball) during kidney cryoablation. Precise intraoperative guidance is critical in cryoablation to ensure complete tumor eradication while preserving adjacent healthy tissue. However, conventional methods, typically based on physics driven or diffusion based simulations, are computationally demanding and often struggle to represent complex anatomical structures accurately. To address these limitations, our approach leverages intraoperative CT imaging to inform the model. The proposed 3D flow matching model is trained to learn a continuous deformation field that maps early-stage CT scans to future predictions. This transformation not only estimates the volumetric expansion of the iceball but also generates corresponding segmentation masks, effectively capturing spatial and morphological changes over time. Quantitative analysis highlights the model robustness, demonstrating strong agreement between predictions and ground-truth segmentations. The model achieves an Intersection over Union (IoU) score of 0.61 and a Dice coefficient of 0.75. By integrating real time CT imaging with advanced deep learning techniques, this approach has the potential to enhance intraoperative guidance in kidney cryoablation, improving procedural outcomes and advancing the field of minimally invasive surgery.

eess.IV↗

arXiv2025

Distribution-aware Fairness Learning in Medical Image Segmentation From A Control-Theoretic Perspective

Ensuring fairness in medical image segmentation is critical due to biases in imbalanced clinical data acquisition caused by demographic attributes (e.g., age, sex, race) and clinical factors (e.g., disease severity). To address these challenges, we introduce Distribution-aware Mixture of Experts (dMoE), inspired by optimal control theory. We provide a comprehensive analysis of its underlying mechanisms and clarify dMoE's role in adapting to heterogeneous distributions in medical image segmentation. Furthermore, we integrate dMoE into multiple network architectures, demonstrating its broad applicability across diverse medical image analysis tasks. By incorporating demographic and clinical factors, dMoE achieves state-of-the-art performance on two 2D benchmark datasets and a 3D in-house dataset. Our results highlight the effectiveness of dMoE in mitigating biases from imbalanced distributions, offering a promising approach to bridging control theory and medical image segmentation within fairness learning paradigms. The source code will be made available. The source code is available at https://github.com/tvseg/dMoE.

eess.IV↗

arXiv2024

An Ordinary Differential Equation Sampler with Stochastic Start for Diffusion Bridge Models

Diffusion bridge models have demonstrated promising performance in conditional image generation tasks, such as image restoration and translation, by initializing the generative process from corrupted images instead of pure Gaussian noise. However, existing diffusion bridge models often rely on Stochastic Differential Equation (SDE) samplers, which result in slower inference speed compared to diffusion models that employ high-order Ordinary Differential Equation (ODE) solvers for acceleration. To mitigate this gap, we propose a high-order ODE sampler with a stochastic start for diffusion bridge models. To overcome the singular behavior of the probability flow ODE (PF-ODE) at the beginning of the reverse process, a posterior sampling approach was introduced at the first reverse step. The sampling was designed to ensure a smooth transition from corrupted images to the generative trajectory while reducing discretization errors. Following this stochastic start, Heun's second-order solver is applied to solve the PF-ODE, achieving high perceptual quality with significantly reduced neural function evaluations (NFEs). Our method is fully compatible with pretrained diffusion bridge models and requires no additional training. Extensive experiments on image restoration and translation tasks, including super-resolution, JPEG restoration, Edges-to-Handbags, and DIODE-Outdoor, demonstrated that our sampler outperforms state-of-the-art methods in both visual quality and Frechet Inception Distance (FID).

cs.CV↗