arXiv subjects

Perrine Chassat

Publications and source records attributed to Perrine Chassat.

4 recordsLinked to original sources

arXiv2025

Shape Analysis of Euclidean Curves under Frenet-Serret Framework

Geometric frameworks for analyzing curves are common in applications as they focus on invariant features and provide visually satisfying solutions to standard problems such as computing invariant distances, averaging curves, or registering curves. We show that for any smooth curve in R^d, d>1, the generalized curvatures associated with the Frenet-Serret equation can be used to define a Riemannian geometry that takes into account all the geometric features of the shape. This geometry is based on a Square Root Curvature Transform that extends the square root-velocity transform for Euclidean curves (in any dimensions) and provides likely geodesics that avoid artefacts encountered by representations using only first-order geometric information. Our analysis is supported by simulated data and is especially relevant for analyzing human motions. We consider trajectories acquired from sign language, and show the interest of considering curvature and also torsion in their analysis, both being physically meaningful.

stat.ME↗

arXiv2025

Toward Valid Generative Clinical Trial Data with Survival Endpoints

Clinical trials face mounting challenges: fragmented patient populations, slow enrollment, and unsustainable costs, particularly for late phase trials in oncology and rare diseases. While external control arms built from real-world data have been explored, a promising alternative is the generation of synthetic control arms using generative AI. A central challenge is the generation of time-to-event outcomes, which constitute primary endpoints in oncology and rare disease trials, but are difficult to model under censoring and small sample sizes. Existing generative approaches, largely GAN-based, are data-hungry, unstable, and rely on strong assumptions such as independent censoring. We introduce a variational autoencoder (VAE) that jointly generates mixed-type covariates and survival outcomes within a unified latent variable framework, without assuming independent censoring. Across synthetic and real trial datasets, we evaluate our model in two realistic scenarios: (i) data sharing under privacy constraints, where synthetic controls substitute for original data, and (ii) control-arm augmentation, where synthetic patients mitigate imbalances between treated and control groups. Our method outperforms GAN baselines on fidelity, utility, and privacy metrics, while revealing systematic miscalibration of type I error and power. We propose a post-generation selection procedure that improves calibration, highlighting both progress and open challenges for generative survival modeling.

cs.LG↗

arXiv2022

How to Register a Live onto a Liver ? Partial Matching in the Space of Varifolds

Partial shapes correspondences is a problem that often occurs in computer vision (occlusion, evolution in time...). In medical imaging, data may come from different modalities and be acquired under different conditions which leads to variations in shapes and topologies. In this paper we use an asymmetric data dissimilarity term applicable to various geometric shapes like sets of curves or surfaces, assessing the embedding of a shape into another one without relying on correspondences. It is designed as a data attachment for the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework, allowing to compute a meaningful deformation of one shape onto a subset of the other. We refine it in order to control the resulting non-rigid deformations and provide consistent deformations of the shapes along with their ambient space. We show that partial matching can be used for robust multi-modal liver registration between a Computed Tomography (CT) volume and a Cone Beam Computed Tomography (CBCT) volume. The 3D imaging of the patient CBCT at point of care that we call live is truncated while the CT pre-intervention provides a full visualization of the liver. The proposed method allows the truncated surfaces from CBCT to be aligned non-rigidly, yet realistically, with surfaces from CT with an average distance of 2.6mm(+/- 2.2). The generated deformations extend consistently to the liver volume, and are evaluated on points of interest for the physicians, with an average distance of 5.8mm (+/- 2.7) for vessels bifurcations and 5.13mm (+/- 2.5) for tumors landmarks. Such multi-modality volumes registrations would help the physicians in the perspective of navigating their tools in the patient's anatomy to locate structures that are hardly visible in the CBCT used during their procedures. Our code is available at https://github.com/plantonsanti/PartialMatchingVarifolds.

eess.IV↗

arXiv2022

Curvature and Torsion estimation of 3D functional data: A geometric approach to build the mean shape under the Frenet Serret framework

The analysis of curves has been routinely dealt with using tools from functional data analysis. However its extension to multi-dimensional curves poses a new challenge due to its inherent geometric features that are difficult to capture with the classical approaches that rely on linear approximations. We develop an alternative characterization of a mean that reflects shape variation of the curves. Based on a geometric representation of the curves through the Frenet-Serret ordinary differential equations, we introduce a new definition of mean curvature and mean torsion, as well as mean shape through the notion of mean vector field. This new formulation of the mean for multi-dimensional curves allows us to integrate the parameters for the shape features into the unified functional data modelling framework. We formulate the estimation problem of the functional parameters in a penalized regression and develop an efficient algorithm. We demonstrate our approach with both simulated data and real data examples.

stat.ME↗