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Peter Elbau

Publications and source records attributed to Peter Elbau.

At least 19 recordsLinked to original sources

Invertibility of the Fourier Diffraction Relation in Raster Scan Diffraction Tomography

Diffraction tomography aims to recover an object's scattering potential from measured wave fields. In the classical setting, the object is illuminated by plane waves from many directions, and the Fourier diffraction theorem provides a direct relation between the Fourier transform of the object's scattering potential and the Fourier transform of the measurements. In many practical imaging systems, however, focused beams are used instead of plane waves. These beams are then translated across the object to bring different regions of interest into focus. This article discusses what information about the scattering potential can be extracted from such measurements. As in the classical case, the analysis is based on a recently derived Fourier diffraction relation that relates the measurements to the Fourier coefficients of the scattering potential. However, this relation does not immediately provide an explicit reconstruction formula, but instead leads to a linear equation system for the Fourier coefficients. We therefore prove in this work that all Fourier coefficients appearing in these relations are in dimensions higher than two generically uniquely determined. In the two-dimensional case, on the other hand, only a particular subset of the Fourier coverage is uniquely recoverable, while on the remaining region distinct coefficients may produce identical data.

math.NA

Raster Scan Diffraction Tomography

Diffraction tomography is a widely used inverse scattering technique for quantitative imaging of weakly scattering media. In its conventional formulation, diffraction tomography assumes monochromatic plane wave illumination. This assumption, however, represents a simplification that often fails to reflect practical imaging systems such as medical ultrasound, where focused beams are used to scan a region of interest of the human body. Such measurement setups, combining focused illumination with scanning, have not yet been incorporated into the diffraction tomography framework. To bridge this gap, we extend diffraction tomography by modeling incident fields as Herglotz waves, thereby incorporating focused beams into the theory. Within this setting, we derive a new Fourier diffraction relation, which forms the basis for quantitative tomographic reconstruction from scanning data. Using this result, we systematically analyze how different scan geometries influence the reconstruction.

math.NA

Uniqueness of Angular Velocity Reconstruction in Parallel-Beam and Diffraction Tomography

This work addresses the problem of uniquely determining a rotational motion from continuous time-dependent measurements within the frameworks of parallel-beam and diffraction tomography. The motivation stems from the challenge of imaging trapped biological samples manipulated and rotated using optical or acoustic tweezers. We analyze the conditions under which the rotation of the unknown sample can be uniquely recovered using the infinitesimal common line and circle method, respectively. We provide explicit criteria for the sample's structure and the induced motion that guarantee unique reconstruction of all rotation parameters. Moreover, we demonstrate that the set of objects for which uniqueness fails is nowhere dense.

math.FA

Quantitative Parameter Reconstruction from Optical Coherence Tomographic Data

Quantitative tissue information, like the light scattering properties, is considered as a key player in the detection of cancerous cells in medical diagnosis. A promising method to obtain these data is optical coherence tomography (OCT). In this article, we will therefore discuss the refractive index reconstruction from OCT data, employing a Gaussian beam based forward model. We consider in particular samples with a layered structure, meaning that the refractive index as a function of depth is well approximated by a piece-wise constant function. For the reconstruction, we present a layer-by-layer method where in every step the refractive index is obtained via a discretized least squares minimization. For an approximated form of the minimization problem, we present an existence and uniqueness result. The applicability of the proposed method is then verified by reconstructing refractive indices of layered media from both simulated and experimental OCT data.

math.NA

A Variant Prescribed Curvature Flow on Closed Surfaces with Negative Euler Characteristic

On a closed Riemannian surface $(M,\bar g)$ with negative Euler characteristic, we study the problem of finding conformal metrics with prescribed volume $A>0$ and the property that their Gauss curvatures $f_\lambda= f + \lambda$ are given as the sum of a prescribed function $f \in C^\infty(M)$ and an additive constant $\lambda$. Our main tool in this study is a new variant of the prescribed Gauss curvature flow, for which we establish local well-posedness and global compactness results. In contrast to previous work, our approach does not require any sign conditions on $f$. Moreover, we exhibit conditions under which the function $f_\lambda$ is sign changing and the standard prescribed Gauss curvature flow is not applicable.

math.AP

Motion Detection in Diffraction Tomography by Common Circle Methods

The method of common lines is a well-established reconstruction technique in cryogenic electron microscopy (cryo-EM), which can be used to extract the relative orientations of an object given tomographic projection images from different directions. In this paper, we deal with an analogous problem in optical diffraction tomography. Based on the Fourier diffraction theorem, we show that rigid motions of the object, i.e., rotations and translations, can be determined by detecting common circles in the Fourier-transformed data. We introduce two methods to identify common circles. The first one is motivated by the common line approach for projection images and detects the relative orientation by parameterizing the common circles in the two images. The second one assumes a smooth motion over time and calculates the angular velocity of the rotational motion via an infinitesimal version of the common circle method. Interestingly, using the stereographic projection, both methods can be reformulated as common line methods, but these lines are, in contrast to those used in cryo-EM, not confined to pass through the origin and allow for a full reconstruction of the relative orientations. Numerical proof-of-the-concept examples demonstrate the performance of our reconstruction methods.

math.NA

Development of mathematical models for quantitative OCT: A review

We review mathematical models describing how Optical Coherence Tomography works. Hereby, we focus on models based on Maxwell's equations and their simplifications. We highlight especially the effects of different modeling assumptions for the incident illumination, the medium, the light propagation, and the measurement setup and illustrate the qualitatively differing behavior in numerical simulations of the OCT data and compare them with real data from OCT measurements.

physics.optics

A Quantitative Model for Optical Coherence Tomography

Optical coherence tomography (OCT) is a widely used imaging technique in the micrometer regime, which gained accelerating interest in medical imaging in the last twenty years. In up-to-date OCT literature [5,6] certain simplifying assumptions are made for the reconstructions, but for many applications a more realistic description of the OCT imaging process is of interest. In mathematical models, for example, the incident angle of light onto the sample is usually neglected or a plane wave description for the light-sample interaction in OCT is used, which ignores almost completely the occurring effects within an OCT measurement process. In this article, we make a first step to a quantitative model by considering the measured intensity as a combination of back-scattered Gaussian beams affected by the system. In contrast to the standard plane wave simplification, the presented model includes system relevant parameters such as the position of the focus and the spot size of the incident laser beam, which allow a precise prediction of the OCT data and therefore ultimately serves as a forward model. The accuracy of the proposed model - after calibration of all necessary system parameters - is illustrated by simulations and validated by a comparison with experimental data obtained from a 1300 nm swept-source OCT system.

physics.med-ph

Reconstructing the Optical Parameters of a Layered Medium with Optical Coherence Elastography

In this work we consider the inverse problem of reconstructing the optical properties of a layered medium from an elastography measurement where optical coherence tomography is used as the imaging method. We hereby model the sample as a linear dielectric medium so that the imaging parameter is given by its electric susceptibility, which is a frequency- and depth-dependent parameter. Additionally to the layered structure (assumed to be valid at least in the small illuminated region), we allow for small scatterers which we consider to be randomly distributed, a situation which seems more realistic compared to purely homogeneous layers. We then show that a unique reconstruction of the susceptibility of the medium (after averaging over the small scatterers) can be achieved from optical coherence tomography measurements for different compression states of the medium.

math.NA

Inverse Problems of Trapped Objects

Optical and acoustical trapping has been established as a tool for holding and moving microscopic particles suspended in a liquid in a contact-free and non-invasive manner. Opposed to standard microscopic imaging where the probe is fixated, this technique allows imaging in a more natural environment. This paper provides a method for estimating the movement of a transparent particle which is maneuvered by tweezers, assuming that the inner structure of the probe is not subject to local movements. The mathematical formulation of the motion estimation shows some similarities to Cryo-EM single particle imaging, where the recording orientations of the probe need to be estimated.

math.NA

Quantitative OCT reconstructions for dispersive media

We consider the problem of reconstructing the position and the time-dependent optical properties of a linear dispersive medium from OCT measurements. The medium is multi-layered described by a piece-wise inhomogeneous refractive index. The measurement data are from a frequency-domain OCT system and we address also the phase retrieval problem. The parameter identification problem can be formulated as an one-dimensional inverse problem. Initially, we deal with a non-dispersive medium and we derive an iterative scheme that is the core of the algorithm for the frequency-dependent parameter. The case of absorbing medium is also addressed.

math.NA

Convergence Rates of First and Higher Order Dynamics for Solving Linear Ill-posed Problems

Recently, there has been a great interest in analysing dynamical flows, where the stationary limit is the minimiser of a convex energy. Particular flows of great interest have been continuous limits of Nesterov's algorithm and the Fast Iterative Shrinkage-Thresholding Algorithm (FISTA), respectively. In this paper we approach the solutions of linear ill-posed problems by dynamical flows. Because the squared norm of the residuum of a linear operator equation is a convex functional, the theoretical results from convex analysis for energy minimising flows are applicable. We prove that the proposed flows for minimising the residuum of a linear operator equation are optimal regularisation methods and that they provide optimal convergence rates for the regularised solutions. In particular we show that in comparison to convex analysis results the rates can be significantly higher, which is possible by constraining the investigations to the particular convex energy functional, which is the squared norm of the residuum.

math.OC

Quantitative reconstructions in multi-modal photoacoustic and optical coherence tomography imaging

In this paper we perform quantitative reconstruction of the electric susceptibility and the Grüneisen parameter of a non-magnetic linear dielectric medium using measurement of a multi-modal photoacoustic and optical coherence tomography system. We consider the mathematical model presented in [11], where a Fredholm integral equation of the first kind for the Grüneisen parameter was derived. For the numerical solution of the integral equation we consider a Galerkin type method.

math.AP

The inverse scattering problem for orthotropic media in Polarization-sensitive Optical Coherence Tomography

In this paper we provide a mathematical model for imaging an anisotropic, orthotropic medium with Polarization-Sensitive Optical Coherence Tomography (PS-OCT). The imaging problem is formulated as an inverse scattering problem in three dimensions for reconstructing the electrical susceptibility of the medium using Maxwell's equations. Our reconstruction method is based on the second-order Born-approximation of the electric field.

math.AP

Quantitative Photoacoustic Imaging in the Acoustic Regime using SPIM

While in standard photoacoustic imaging the propagation of sound waves is modeled by the standard wave equation, our approach is based on a generalized wave equation with variable sound speed and material density, respectively. In this paper we present an approach for photoacoustic imaging, which in addition to recovering of the absorption density parameter, the imaging parameter of standard photoacoustics, also allows to reconstruct the spatially varying sound speed and density, respectively, of the medium. We provide analytical reconstruction formulas for all three parameters based in a linearized model based on single plane illumination microscopy (SPIM) techniques.

math.AP

Singular Values of the Attenuated Photoacoustic Imaging Operator

We analyse the ill-posedness of the photoacoustic imaging problem in the case of an attenuating medium. To this end, we introduce an attenuated photoacoustic operator and determine the asymptotic behaviour of its singular values. Dividing the known attenuation models into strong and weak attenuation classes, we show that for strong attenuation, the singular values of the attenuated photoacoustic operator decay exponentially, and in the weak attenuation case the singular values of the attenuated photoacoustic operator decay with the same rate as the singular values of the non-attenuated photoacoustic operator.

math.FA

Inverse Problems of Combined Photoacoustic and Optical Coherence Tomography

Optical coherence tomography (OCT) and photoacoustic tomography (PAT) are emerging non-invasive biological and medical imaging techniques. It is a recent trend in experimental science to design experiments that perform PAT and OCT imaging at once. In this paper we present a mathematical model describing the dual experiment. Since OCT is mathematically modelled by Maxwell's equations or some simplifications of it, whereas the light propagation in quantitative photoacoustics is modelled by (simplifications of) the radiative transfer equation, the first step in the derivation of a mathematical model of the dual experiment is to obtain a unified mathematical description, which in our case are Maxwell's equations. As a by-product we therefore derive a new mathematical model of photoacoustic tomography based on Maxwell's equations. It is well known by now, that without additional assumptions on the medium, it is not possible to uniquely reconstruct all optical parameters from either one of these modalities alone. We show that in the combined approach one has additional information, compared to a single modality, and the inverse problem of reconstruction of the optical parameters becomes feasible.

math.AP

Optimal Convergence Rates Results for Linear Inverse Problems in Hilbert Spaces

In this paper, we prove optimal convergence rates results for regularisation methods for solving linear ill-posed operator equations in Hilbert spaces. The result generalises existing convergence rates results on optimality to general source conditions, such as logarithmic source conditions. Moreover, we also provide optimality results under variational source conditions and show the connection to approximative source conditions.

math.FA