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Peter Keller

Publications and source records attributed to Peter Keller.

3 recordsLinked to original sources

Fixation probability in Moran-like Processes on graphs

The well-known Isothermal Theorem was introduced in a Nature Communications article in 2005 and has since contributed to the creation of the rich field of evolutionary graph theory. The theorem states under which conditions certain Moran-like processes on graphs ("spatial Moran Processes") have the same fixation probability as the classic one-dimensional Moran Process that was introduced by Moran in 1958. Unfortunately, the Isothermal Theorem has never been proven completely. The main argument, that the projection of the process on the graph dynamics onto a one-dimensional process is a Birth-and-Death-Process, is not true in general, as the projection does not need to be Markovian. The aim of this paper is to present a more general version of the Isothermal Theorem using martingale techniques and a generalised framework using matrix notation. We follow up with a short study of small population size that shows the set of spatial Moran Processes with Moran fixation probability is even richer than previously understood. We underline the role played by the initial condition, and how individuals of the population are chosen for procreation.

math.PR

Commissioning of the novel Continuous Angle Multi-Energy Analysis Spectrometer at the Paul Scherrer Institut

We report on the commissioning results of the cold neutron multiplexing secondary spectrometer CAMEA (\textbf{C}ontinuous \textbf{A}ngle \textbf{M}ulti-\textbf{E}nergy \textbf{A}nalysis) at the Swiss Spallation Neutron Source (SINQ) at the Paul Scherrer Institut, Switzerland. CAMEA is optimized for an efficient data acquisition of scattered neutrons in the horizontal scattering plane, allowing for detailed and rapid mapping of low-energy excitations under extreme sample environment conditions.

physics.ins-det

Mutant number distribution in an exponentially growing population

We present an explicit solution to a classic model of cell-population growth introduced by Luria and Delbrueck 70 years ago to study the emergence of mutations in bacterial populations. In this model a wild-type population is assumed to grow exponentially in a deterministic fashion. Proportional to the wild-type population size, mutants arrive randomly and initiate new sub-populations of mutants that grows stochastically according to a supercritical birth and death process. We give an exact expression for the generating function of the total number of mutants at a given wild type population size. We present a simple expression for the probability of finding no mutants, and a recursion formula for the probability of finding a given number of mutants. In the "large population-small mutation"-limit we recover recent results of Kessler and Levin for a fully stochastic version of the process.

math.PR