Peter Schier | Searcharxiv

arXiv2019

European research on magnetic nanoparticles for biomedical applications: standardisation aspects

Magnetic nanoparticles have many applications in biomedicine and other technical areas. Despite their huge economic impact, there are no standardised procedures available to measure their basic magnetic properties. The International Organization for Standardization is working on a series of documents on the definition of characteristics of magnetic nanomaterials. We review previous and ongoing European research projects on characteristics of magnetic nanoparticles and present results of an online survey among European researchers.

physics.med-ph↗

arXiv2018

Douglas-Rachford Algorithm for Magnetorelaxometry Imaging using Random and Deterministic Activations

Magnetorelaxometry imaging is a novel tool for quantitative determination of the spatial distribution of magnetic nanoparticle inside an organism. The use of multiple excitation patterns has been demonstrated to significantly improve spatial resolution. However, increasing the number of excitation patterns is considerably more time consuming, because several sequential measurements have to be performed. In this paper, we use compressed sensing in combination with sparse recovery to reduce the total measurement time and to improve spatial resolution. For image reconstruction, we propose using the Douglas-Rachford splitting algorithm applied to the sparse Tikhonov functional including a positivity constraint. Our numerical experiments demonstrate that the resulting algorithm is capable to accurately recover the magnetic nanoparticle distribution from a small number of activation patterns. For example, our algorithm applied with 10 activations yields half the reconstruction error of quadratic Tikhonov regularization applied with 50 activations, for a tumor-like phantom.

math.NA↗