arXiv subjects

Phanindra Dewan

Publications and source records attributed to Phanindra Dewan.

3 recordsLinked to original sources

arXiv2026

Symmetry-protected phases in a 1D active solid with mechanochemical feedback

We present a framework for mechanochemical self-organization in active solids where elasticity is reciprocally coupled to Hopf oscillators. Our model reveals a rich landscape of symmetry-protected phases, identified through amplitude equations and group-theoretic analysis. We uncover a universal transition to compression-driven oscillation death (COD), providing a physical basis for localized signaling dampening in biological tissues that resolves inconsistencies in previous models. Our work demonstrates that complex self-organization in active solids can be classified purely through symmetry arguments.

cond-mat.soft↗

arXiv2026

Molecular communication in one-dimensional channels with active transport and crowding

Molecular communication (MC) is a model of information transmission where the signal is transmitted by information-carrying molecules through their physical transport from a transmitter to a receiver through a communication channel. Prior efforts have identified suitable "information molecules" whose efficacy for signal transmission has been studied extensively in diffusive channels (DC). Although easy to implement, DCs are inefficient for distances longer than tens of nanometers. In contrast, molecular motor-driven nonequilibrium or active transport can drastically increase the range of communication and may permit efficient communication up to tens of micrometers. In this paper, we investigate how active transport influences the efficacy of molecular communication, quantified by the mutual information between transmitted and received signals. We consider two specific scenarios: (a) active transport through relays and (b) active transport through a mixture of active and diffusing particles. In each case, we discuss the efficacy of the communication channel and discuss their potential pitfalls.

cond-mat.stat-mech↗

arXiv2026

Glassy dynamics in active epithelia emerge from an interplay of mechanochemical feedback and crowding

Glassy dynamics in active biological cells remain a subject of debate, as cellular activity rarely slows enough for true glassy features to emerge. In this study, we address this paradox of glassy dynamics in epithelial cells by integrating experimental observations with an active vertex model. We demonstrate that while crowding is essential, it is not sufficient for glassy dynamics to emerge. A mechanochemical feedback loop (MCFL), mediated by cell shape changes through the contractile actomyosin network, is required to drive glass transition in dense epithelial tissues, as revealed via a crosstalk between actin-based cell clustering and dynamic heterogeneity in experiments. Incorporating MCFL into the vertex model reveals contrasting results from those previously predicted by theories -- we show that the MCFL can counteract cell division-induced fluidisation and enable glassy dynamics to emerge through active cell-to-cell communication. Furthermore, our analysis reveals, for the first time, the existence of novel collective mechanochemical oscillations that arise from the crosstalk of two MCFLs. Together, we demonstrate that an interplay between crowding and active mechanochemical feedback enables the emergence of glass-like traits and collective biochemical oscillations in epithelial tissues with active cell-cell contacts.

physics.bio-ph↗