arXiv subjects

Pierre-Étienne Meunier

Publications and source records attributed to Pierre-Étienne Meunier.

12 recordsLinked to original sources

arXiv2020

On the directed tile assembly systems at temperature 1

We show here that a model called directed self-assembly at temperature 1 is unable to do complex computations like the ones of a Turing machine. Since this model can be seen as a generalization of finite automata to 2D languages, a logical approach is to proceed in two steps. The first one is to develop a 2D pumping lemma and the second one is to use this pumping lemma to classify the different types of possible computation. Previously, Meunier at al have proven a pumping lemma and Doty et al, assuming the existence of a pumping lemma, have classified the different types of terminal assembly. Thus the combination of these two papers solves the directed temperature 1 conjecture ... but in an imperfect way. Indeed, since the work of Doty et al is anterior to the pumping lemma of Meunier et al, the authors assumed a different and stronger pumping lemma. Nevertheless, all the demonstrations made in Doty et al still hold with the pumping lemma of Meunier et al. In this paper, we harmonize the notations between these two articles in order to clearly solve the directed temperature 1 conjecture. We are also able to give an optimal description of the bi-periodic structures which may appear in some tile assembly system.

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arXiv2020

The program-size complexity of self-assembled paths

We prove a Pumping Lemma for the noncooperative abstract Tile Assembly Model, a model central to the theory of algorithmic self-assembly since the beginning of the field. This theory suggests, and our result proves, that small differences in the nature of adhesive bindings between abstract square molecules gives rise to vastly different expressive capabilities. In the cooperative abstract Tile Assembly Model, square tiles attach to each other using multi-sided cooperation of one, two or more sides. This precise control of tile binding is directly exploited for algorithmic tasks including growth of specified shapes using very few tile types, as well as simulation of Turing machines and even self-simulation of self-assembly systems. But are cooperative bindings required for these computational tasks? The definitionally simpler noncooperative (or Temperature 1) model has poor control over local binding events: tiles stick if they bind on at least one side. This has led to the conjecture that it is impossible for it to exhibit precisely controlled growth of computationally-defined shapes. Here, we prove such an impossibility result. We show that any planar noncooperative system that attempts to grow large algorithmically-controlled tile-efficient assemblies must also grow infinite non-algorithmic (pumped) structures with a simple closed-form description, or else suffer blocking of intended algorithmic structures. Our result holds for both directed and nondirected systems, and gives an explicit upper bound of $(8|T|)^{4|T|+1}(5|σ| + 6)$, where $|T|$ is the size of the tileset and $|σ|$ is the size of the seed assembly, beyond which any path of tiles is pumpable or blockable.

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arXiv2018

Proving the Turing Universality of Oritatami Co-Transcriptional Folding (Full Text)

We study the oritatami model for molecular co-transcriptional folding. In oritatami systems, the transcript (the "molecule") folds as it is synthesized (transcribed), according to a local energy optimisation process, which is similar to how actual biomolecules such as RNA fold into complex shapes and functions as they are transcribed. We prove that there is an oritatami system embedding universal computation in the folding process itself. Our result relies on the development of a generic toolbox, which is easily reusable for future work to design complex functions in oritatami systems. We develop "low-level" tools that allow to easily spread apart the encoding of different "functions" in the transcript, even if they are required to be applied at the same geometrical location in the folding. We build upon these low-level tools, a programming framework with increasing levels of abstraction, from encoding of instructions into the transcript to logical analysis. This framework is similar to the hardware-to-algorithm levels of abstractions in standard algorithm theory. These various levels of abstractions allow to separate the proof of correctness of the global behavior of our system, from the proof of correctness of its implementation. Thanks to this framework, we were able to computerize the proof of correctness of its implementation and produce certificates, in the form of a relatively small number of proof trees, compact and easily readable and checkable by human, while encapsulating huge case enumerations. We believe this particular type of certificates can be generalized to other discrete dynamical systems, where proofs involve large case enumerations as well.

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arXiv2017

The non-cooperative tile assembly model is not intrinsically universal or capable of bounded Turing machine simulation

The field of algorithmic self-assembly is concerned with the computational and expressive power of nanoscale self-assembling molecular systems. In the well-studied cooperative, or temperature 2, abstract tile assembly model it is known that there is a tile set to simulate any Turing machine and an intrinsically universal tile set that simulates the shapes and dynamics of any instance of the model, up to spatial rescaling. It has been an open question as to whether the seemingly simpler noncooperative, or temperature 1, model is capable of such behaviour. Here we show that this is not the case, by showing that there is no tile set in the noncooperative model that is intrinsically universal, nor one capable of time-bounded Turing machine simulation within a bounded region of the plane. Although the noncooperative model intuitively seems to lack the complexity and power of the cooperative model it was not obvious how to prove this. One reason is that there have been few tools to analyse the structure of complicated paths in the plane. This paper provides a number of such tools. A second reason is that almost every obvious and small generalisation to the model (e.g. allowing error, 3D, non-square tiles, signals/wires on tiles, tiles that repel each other, parallel synchronous growth) endows it with great computational, and sometimes simulation, power. Our main results show that all of these generalisations provably increase computational and/or simulation power. Our results hold for both deterministic and nondeterministic noncooperative systems. Our first main result stands in stark contrast with the fact that for both the cooperative tile assembly model, and for 3D noncooperative tile assembly, there are respective intrinsically universal tilesets. Our second main result gives a new technique (reduction to simulation) for proving negative results about computation in tile assembly.

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arXiv2016

A pumping lemma for non-cooperative self-assembly

We prove a result which strongly hints at the computational weakness of a model of tile assembly that has so far resisted many attempts of formal analysis or positive constructions. Specifically, we prove that, in Winfree's abstract Tile Assembly Model, when restricted to use only noncooperative bindings, any long enough path starting from the seed that can grow in all terminal assemblies is pumpable, meaning that this path can be extended into an infinite, ultimately periodic path. This result can be seen as a geometric generalization of the pumping lemma of finite state automata, and closes the question of what can be computed deterministically in this model. Moreover, this question has motivated the development of a new method called visible glues. We believe that this method can also be used to tackle other long-standing problems in computational geometry, in relation for instance with self-avoiding paths. Tile assembly (including non-cooperative tile assembly) was originally introduced by Winfree and Rothemund in STOC 2000 to understand how to program shapes. The non-cooperative variant, also known as temperature 1 tile assembly, is the model where tiles are allowed to bind as soon as they match on one side, whereas in cooperative tile assembly, some tiles need to match on several sides in order to bind. Previously, exactly one known result (SODA 2014) showed a restriction on the assemblies general non-cooperative self-assembly could achieve, without any implication on its computational expressiveness. With non-square tiles (like polyominos, SODA 2015), other recent works have shown that the model quickly becomes computationally powerful.

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arXiv2015

A pumping lemma for non-cooperative self-assembly

We prove the computational weakness of a model of tile assembly that has so far resisted many attempts of formal analysis or positive constructions. Specifically, we prove that, in Winfree's abstract Tile Assembly Model, when restricted to use only noncooperative bindings, any long enough path that can grow in all terminal assemblies is pumpable, meaning that this path can be extended into an infinite, ultimately periodic path. This result can be seen as a geometric generalization of the pumping lemma of finite state automata, and closes the question of what can be computed deterministically in this model. Moreover, this question has motivated the development of a new method called visible glues. We believe that this method can also be used to tackle other long-standing problems in computational geometry, in relation for instance with self-avoiding paths. Tile assembly (including non-cooperative tile assembly) was originally introduced by Winfree and Rothemund in STOC 2000 to understand how to program shapes. The non-cooperative variant, also known as temperature 1 tile assembly, is the model where tiles are allowed to bind as soon as they match on one side, whereas in cooperative tile assembly, some tiles need to match on several sides in order to bind. In this work, we prove that only very simple shapes can indeed be programmed, whereas exactly one known result (SODA 2014) showed a restriction on the assemblies general non-cooperative self-assembly could achieve, without any implication on its computational expressiveness. With non-square tiles (like polyominos, SODA 2015), other recent works have shown that the model quickly becomes computationally powerful.

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arXiv2015

It's a Tough Nanoworld: in Tile Assembly, Cooperation is not (strictly) more Powerful than Competition

We present a strict separation between the class of "mismatch free" self-assembly systems and general aTAM systems. Mismatch free systems are those systems in which concurrently grown parts must always agree with each other. Tile self-assembly is a model of the formation of crystal growth, in which a large number of particles concurrently and selectively stick to each other, forming complex shapes and structures. It is useful in nanotechnologies, and more generally in the understanding of these processes, ubiquitous in natural systems. The other property of the local assembly process known to change the power of the model is cooperation between two tiles to attach another. We show that disagreement (mismatches) and cooperation are incomparable: neither can be used to simulate the other one. The fact that mismatches are a hard property is especially surprising, since no known, explicit construction of a computational device in tile assembly uses mismatches, except for the recent construction of an intrinsically universal tileset, i.e. a tileset capable of simulating any other tileset up to rescaling. This work shows how to use intrinsic universality in a systematic way to highlight the essence of different features of tile assembly. Moreover, even the most recent experimental realizations do not use competition, which, in view of our results, suggests that a large part of the natural phenomena behind DNA self-assembly remains to be understood experimentally.

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arXiv2014

Noncooperative algorithms in self-assembly

We show the first non-trivial positive algorithmic results (i.e. programs whose output is larger than their size), in a model of self-assembly that has so far resisted many attempts of formal analysis or programming: the planar non-cooperative variant of Winfree's abstract Tile Assembly Model. This model has been the center of several open problems and conjectures in the last fifteen years, and the first fully general results on its computational power were only proven recently (SODA 2014). These results, as well as ours, exemplify the intricate connections between computation and geometry that can occur in self-assembly. In this model, tiles can stick to an existing assembly as soon as one of their sides matches the existing assembly. This feature contrasts with the general cooperative model, where it can be required that tiles match on \emph{several} of their sides in order to bind. In order to describe our algorithms, we also introduce a generalization of regular expressions called Baggins expressions. Finally, we compare this model to other automata-theoretic models.

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arXiv2014

Unraveling simplicity in elementary cellular automata

We show that a large number of elementary cellular automata are computationally simple. This work is the first systematic classification of elementary cellular automata based on a formal notion of computational complexity. Thanks to the generality of communication complexity, the perspectives of our method include its application to other natural systems such as neural networks and gene regulatory networks.

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arXiv2014

Binary pattern tile set synthesis is NP-hard

In the field of algorithmic self-assembly, a long-standing unproven conjecture has been that of the NP-hardness of binary pattern tile set synthesis (2-PATS). The $k$-PATS problem is that of designing a tile assembly system with the smallest number of tile types which will self-assemble an input pattern of $k$ colors. Of both theoretical and practical significance, $k$-PATS has been studied in a series of papers which have shown $k$-PATS to be NP-hard for $k = 60$, $k = 29$, and then $k = 11$. In this paper, we close the fundamental conjecture that 2-PATS is NP-hard, concluding this line of study. While most of our proof relies on standard mathematical proof techniques, one crucial lemma makes use of a computer-assisted proof, which is a relatively novel but increasingly utilized paradigm for deriving proofs for complex mathematical problems. This tool is especially powerful for attacking combinatorial problems, as exemplified by the proof of the four color theorem by Appel and Haken (simplified later by Robertson, Sanders, Seymour, and Thomas) or the recent important advance on the Erdős discrepancy problem by Konev and Lisitsa using computer programs. We utilize a massively parallel algorithm and thus turn an otherwise intractable portion of our proof into a program which requires approximately a year of computation time, bringing the use of computer-assisted proofs to a new scale. We fully detail the algorithm employed by our code, and make the code freely available online.

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arXiv2013

The self-assembly of paths and squares at temperature 1

We prove that the number of tile types required to build squares of size n x n, in Winfree's abstract Tile Assembly Model, when restricted to using only non-cooperative tile bindings, is at least 2n-1, which is also the best known upper bound. Non-cooperative self-assembly, also known as temperature 1, is where tiles bind to each other if they match on one or more sides, whereas in cooperative binding, some tiles can bind only if they match on multiple sides. Our proof introduces a new programming technique for temperature 1, that disproves the very intuitive and commonly held belief that, in the same model, assembling paths between two points A and B cannot be done with less tile types than the Manhattan distance between them. Then, we prove a necessary condition for these "efficient paths" to be assembled, and show that this necessary condition cannot hold in completely filled squares. This result proves the oldest conjecture in algorithmic self-assembly, published by Rothemund and Winfree in STOC 2000, in the case where growth starts from a corner of the square. As a corollary, we establish n as a lower bound on the tile complexity of the general case. The problem of determining the minimal number of tile types to self-assemble a shape is known to be Sigma^p_2-complete.

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arXiv2013

Intrinsic universality in tile self-assembly requires cooperation

We prove a negative result on the power of a model of algorithmic self-assembly for which it has been notoriously difficult to find general techniques and results. Specifically, we prove that Winfree's abstract Tile Assembly Model, when restricted to use noncooperative tile binding, is not intrinsically universal. This stands in stark contrast to the recent result that, via cooperative binding, the abstract Tile Assembly Model is indeed intrinsically universal. Noncooperative self-assembly, also known as "temperature 1", is where tiles bind to each other if they match on one or more sides, whereas cooperative binding requires binding on multiple sides. Our result shows that the change from single- to multi-sided binding qualitatively improves the kinds of dynamics and behavior that these models of nanoscale self-assembly are capable of. Our lower bound on simulation power holds in both two and three dimensions; the latter being quite surprising given that three-dimensional noncooperative tile assembly systems simulate Turing machines. On the positive side, we exhibit a three-dimensional noncooperative self-assembly tile set capable of simulating any two-dimensional noncooperative self-assembly system. Our negative result can be interpreted to mean that Turing universal algorithmic behavior in self-assembly does not imply the ability to simulate arbitrary algorithmic self-assembly processes.

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