arXiv subjects

Pietro Biroli

Publications and source records attributed to Pietro Biroli.

8 recordsLinked to original sources

arXiv2026

Sources of Inequality at Birth: The Interplay Between Genes and Parental Socioeconomic Status

The start of a human's life can be characterized by two lotteries: that of your genes (nature) and the family you were born into (nurture). These set in motion a trajectory, from birth onward, in health and human capital. Leveraging three longitudinal social-science data sets, we systematically analyze the relationship between an individual's genotype, the socioeconomic status (SES) of the families they grew up in, and their realized traits in adulthood. We proxy an individual's genetic predisposition by polygenic indexes (PGIs) and family SES by a latent factor of parental education and father's (former) occupational status. We then investigate how PGIs, parental SES, and their interaction contribute to later-life outcomes across a range of forty-five socioeconomic, anthropometric, health, behavioral, and personality traits. We find strong genetic and socioeconomic associations with these phenotypes, but no evidence of sizable gene-environment interactions.

econ.GN↗

arXiv2026

Tracing the Genetic Footprints of the UK National Health Service

The establishment of the UK National Health Service (NHS) in July 1948 was one of the most consequential health policy interventions of the twentieth century, providing universal and free access to medical care and substantially expanding maternal and infant health services. In this paper, we estimate the causal effect of the NHS introduction on early-life mortality and we test whether survival is selective. We adopt a regression discontinuity design under local randomization, comparing individuals born just before and just after July 1948. Leveraging newly digitized weekly death records, we document a significant decline in stillbirths and infant mortality following the introduction of the NHS, the latter driven primarily by reductions in deaths from congenital conditions and diarrhea. We then use polygenic indexes (PGIs), fixed at conception, to track changes in population composition, showing that cohorts born at or after the NHS introduction exhibit higher PGIs associated with contextually-adverse traits (e.g., depression, COPD, and preterm birth) and lower PGIs associated with contextually-valued traits (e.g., educational attainment, self-rated health, and pregnancy length), with effect sizes as large as 7.5% of a standard deviation. These results based on the UK Biobank data are robust to family-based designs and replicate in the English Longitudinal Study of Ageing and the UK Household Longitudinal Study. Effects are strongest in socioeconomically disadvantaged areas and among males. This novel evidence on the existence and magnitude of selective survival highlights how large-scale public policies can leave a persistent imprint on population composition and generate long-term survival biases.

econ.GN↗

arXiv2025

Aggregating Epigenetic Clocks to Study Human Capital Formation

Epigenetics is the study of how people's behavior and environments influence the way their genes are expressed, even though their DNA sequence is itself unchanged. By aggregating age-related epigenetic markers, epigenetic 'clocks' have become the leading tool for studying biological aging. We make an important contribution by developing a novel, integrated measure of epigenetic aging--the Multi EpiGenetic Age (MEGA) clock--which combines several existing epigenetic clocks to reduce measurement error and improve estimation efficiency. We use the MEGA clock in three empirical contexts to show that: i) accelerated epigenetic aging in adolescence is associated with worse educational, mental-health, and labor market outcomes in early adulthood; ii) exposure to child maltreatment before adolescence is associated with half a year higher epigenetic aging; and iii) that entering school one year later accelerates epigenetic aging by age seven, particularly among disadvantaged children. The MEGA clock is robust to alternative methods for constructing it, providing a flexible and interpretable approach for incorporating epigenetic data into a wide variety of settings.

econ.GN↗

arXiv2025

Beyond Time: Unveiling the Invisible Burden of Mental Load

This paper introduces a novel, scalable methodology to measure individual perceptions of gaps in mental load -- the cognitive and emotional burden associated with organizing household and childcare tasks -- within heterosexual couples. Using original data from the TIMES Observatory in Italy, the study combines time-use diaries with new survey indicators to quantify cognitive labor, emotional fatigue, and the spillover of mental load into the workplace. Results reveal systematic gender asymmetries: women are significantly more likely than men to bear organizational responsibility for domestic tasks, report lower satisfaction with this division, and experience higher emotional fatigue. These burdens are underestimated by their partners. The effects are particularly pronounced among college-educated and employed women, who also report greater spillovers of family responsibilities than men during paid work hours. The perceived responsibility for managing family activities is more strongly associated with within-couple gaps in time use than with the absolute time spent on their execution, underscoring the relational and conflictual nature of mental load.

econ.GN↗

arXiv2025

Seeing Stereotypes

Reliance on stereotypes is a persistent feature of human decision-making and has been extensively documented in educational settings, where it can shape students' confidence, performance, and long-term human capital accumulation. While effective techniques exist to mitigate these negative effects, a crucial first step is to establish whether teachers can recognize stereotypes in their professional environment. We introduce the Stereotype Identification Test (SIT), a novel survey tool that asks teachers to evaluate and comment on the presence of stereotypes in images randomly drawn from school textbooks. Their responses are systematically linked to established measures of implicit bias (Implicit Association Test, IAT) and explicit bias (survey scales on teaching stereotypes and social values). Our findings demonstrate that the SIT is a valid and reliable measure of stereotype recognition. Teachers' ability to recognize stereotypes is linked to trainable traits such as implicit bias awareness and inclusive teaching practices. Moreover, providing personalized feedback on implicit bias improves SIT scores by 0.25 standard deviations, reinforcing the idea that stereotype recognition is malleable and can be enhanced through targeted interventions.

econ.GN↗

arXiv2022

Gene-Environment Interplay in the Social Sciences

Nature (one's genes) and nurture (one's environment) jointly contribute to the formation and evolution of health and human capital over the life cycle. This complex interplay between genes and environment can be estimated and quantified using genetic information readily available in a growing number of social science data sets. Using genetic data to improve our understanding of individual decision making, inequality, and to guide public policy is possible and promising, but requires a grounding in essential genetic terminology, knowledge of the literature in economics and social-science genetics, and a careful discussion of the policy implications and prospects of the use of genetic data in the social sciences and economics.

econ.GN↗

arXiv2022

Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age

Adverse conditions in early life can have consequential impacts on individuals' health in older age. In one of the first papers on this topic, Barker and Osmond 1986 show a strong positive relationship between infant mortality rates in the 1920s and ischaemic heart disease in the 1970s. We go 'beyond Barker', first by showing that this relationship is robust to the inclusion of local geographic area fixed effects, but not family fixed effects. Second, we explore whether the average effects conceal underlying heterogeneity: we examine if the infant mortality effect offsets or reinforces one's genetic predisposition for heart disease. We find considerable heterogeneity that is robust to within-area as well as within-family analyses. Our findings show that the effects of one's early life environments mainly affect individuals with the highest genetic risk for developing heart disease. Put differently, in areas with the lowest infant mortality rates, the effect of one's genetic predisposition effectively vanishes. These findings suggest that advantageous environments can cushion one's genetic risk of developing heart disease.

econ.GN↗

arXiv2022

The Economics and Econometrics of Gene-Environment Interplay

Economists and social scientists have debated the relative importance of nature (one's genes) and nurture (one's environment) for decades, if not centuries. This debate can now be informed by the ready availability of genetic data in a growing number of social science datasets. This paper explores the potential uses of genetic data in economics, with a focus on estimating the interplay between nature (genes) and nurture (environment). We discuss how economists can benefit from incorporating genetic data into their analyses even when they do not have a direct interest in estimating genetic effects. We argue that gene--environment (GxE) studies can be instrumental for (i) testing economic theory, (ii) uncovering economic or behavioral mechanisms, and (iii) analyzing treatment effect heterogeneity, thereby improving the understanding of how (policy) interventions affect population subgroups. We introduce the reader to essential genetic terminology, develop a conceptual economic model to interpret gene-environment interplay, and provide practical guidance to empirical researchers.

econ.GN↗