arXiv subjects

Pragya Das

Publications and source records attributed to Pragya Das.

3 recordsLinked to original sources

arXiv2026

Roadmap Towards Quantum Entanglement Positron Emission Tomography (QE-PET)

Annihilation photons are quantum entangled in their polarization, a property that is not accessible in state-of-the-art clinical Positron Emission Tomography (PET). This roadmap describes the current status of research in the emerging field of quantum entanglement applications involving these photons for medical diagnosis. It outlines the underlying physics phenomena and the development of detector systems that can serve as a foundation for future Quantum Entanglement PET (QE-PET) scanners. These scanners will be capable of utilizing the entanglement between annihilation photons by measuring their Compton scattering on electrons. This roadmap comprises up-to-date experimental results on the study of quantum entanglement and the decoherence of annihilation photons, alongside the current theoretical understanding of these phenomena. The methods and detector technologies described herein are being developed (i) in order to enhance standard PET imaging by suppressing random coincidences in the reconstruction of annihilation site density distributions, (ii) in order to establish the degree of quantum entanglement as a diagnostic biomarker for tissue pathology and oxygenation, and (iii) in order to elaborate a method for pH imaging. Whether entanglement-based imaging and pH mapping can be successfully translated into clinical practice remains an open question and a subject of exciting ongoing research. This roadmap serves as an invitation to the scientific community to join this burgeoning field.

physics.med-ph↗

arXiv2022

Virtual extrapolation technique for retracing line of response of single scattered events in positron emission tomography

Purpose: The scattering phenomenon creates degrading effects in positron emission tomography (PET) and the corresponding events are rejected conventionally. We have proposed a mathematical model to retrace the original line of response of the single-scattered coincident events with the aim to incorporate such events in PET. Methods: We have devised a new Virtual extrapolation technique based on the concept of the probability density functions. Through which we transformed the original two-parameter list mode data for the coincident photon pairs to a one-parameter data set. The procedure of random sampling and sampling distribution - by utilizing some unique properties like a collective difference and the length compensation - was employed in the data analysis. We studied the effect of finite timing and energy resolution of detectors on the performance of the proposed model. Results: We determined the frequency of occurrence of the data values corresponding to real as well as fictitious scattering points { placed on the arc of a circle drawn with the constant scattering angle - to observe the highest counts. As expected, we found the highest counts at the location of real scattering points. The model was evaluated for a uniform attenuating phantom medium. The results were found impressive for the case of ideal time and energy information, less so for the cases of finite resolutions. Conclusions: Our work outlines a completely new approach; though, a lot more sophistication is required for its practical utility. Nonetheless, the technique seems promising in developing a potential approach to improve the sensitivity of PET imaging.

physics.med-ph↗

arXiv2021

Image reconstruction from tissue scattered events for $β^{+}γ$ coincidences in Compton-PET

For long time non-pure beta emitters are avoided from PET imaging due to extra dose and increase in background from Compton scattering. But advent of high-resolution Compton camera system opens up new domain of imaging. Various non-pure beta emitters are formed as beam irradiation byproduct in therapy which can be used in online beam range verification. In this case, the number of usable counts for imaging is generally 1-3 order lesser than normal PET scan. On the other hand, we know that in human PET scanner, 30-60\% can be tissue scattered coincidences in 3D case containing 80\% single scattered events. In this work, we have investigated feasibility of imaging using only single scattered coincidences for non-pure beta emitters in a Compton-PET system. The locus of tissue scatter point can be reduced to in generally two points after using Compton cone from both ends of 511 keV detections. Finally, annihilation point is estimated using Compton cone of 1157 keV gamma and time-of-flight information for the 511 keV. We believe independent assessment of underlying activity from single scattered data sets will increase confidence in image interpretation.

physics.med-ph↗