arXiv subjects

Prasenjit Kabi

Publications and source records attributed to Prasenjit Kabi.

4 recordsLinked to original sources

arXiv2024

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

The transmission of viruses/ bacteria cause infection predominantly via aerosols. The transmission mechanism of respiratory diseases is complex, including direct or indirect contact, large droplet, and airborne routes apart from close contact transmission. With this pretext, we have investigated two modes of droplet evaporation to understand its significance in airborne disease transmission; a droplet in a contact-free environment, which evaporates and forms droplet nuclei, and a droplet on a hydrophilic substrate (fomite). The study examines mass transport, the deposition pattern of bacteria in the precipitates, and their survival and virulence. The osmotic pressure increases with the salt concentration, inactivating the bacteria embedded in the precipitates with accelerated evaporation. Further, the bacteria's degree of survival and enhanced pathogenicity are compared for both evaporation modes. The striking differences in pathogenicity are attributed to the evaporation rate, oxygen availability, and reactive oxygen species (ROS) generation.

physics.bio-ph↗

arXiv2020

Dynamics of Droplet Generation from Corneal Tear Film during Non-contact Eye Procedure in the Context of COVID-19

Non-invasive medical diagnostics demonstrate a propensity for droplet generation and should be studied to devise risk mitigation strategies against the spread of the SARS-CoV-2 virus. We investigate the air-puff tonometry, which uses a short-timed air-puff to applanate the human eye in a bid to detect the early onset of glaucoma by measuring the intraocular pressure. The air-puff consists of a vortex trailed by a high-speed jet. High-speed imaging of the eye during a typical tonometry measurement reveals a sequence of events starting with the interaction between the tear layer and the air puff leading to an initial sheet ejection. It is immediately followed by the trailing jet applanating the central corneal section, causing capillary waves to form and interact with the highly 3D transient expanding sheet. Such interaction with the capillary waves and the surrounding airfield due to the trailing jet causes the expanding sheet to undergo bag breakup, finger formation by Rayleigh Taylor instability and further break up into subsequent droplets by Rayleigh Plateau instability, which eventually splashes onto nearby objects, potentially forming fomites or aerosols which can lead to infections. The complex spatiotemporal phenomenon is carefully documented by rigorous experiments and corroborated using comprehensive theoretical analyses.

physics.med-ph↗

arXiv2020

Insights on drying and precipitation dynamics of respiratory droplets in the perspective of Covid-19

We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into the infectivity of air borne nuclei during the Covid-19 pandemic. Evaporation experiments are performed with salt-water solutions seeded with a viral load of inactive nanoparticles in an acoustic levitator. We seek to emulate the drying, flow and precipitation dynamics of such air borne mucosalivary droplets. Observations with the surrogate fluid are validated by similar experiments with actual samples from a healthy subject. A unique feature emerges with regards to the final crystallite dimension; it is always 20-30% of the initial droplet diameter for different sizes and ambient conditions. The preserved precipitates from levitated droplets show that 15% of the total virion population remain dispersed on the outer surface of air-desiccated air borne nuclei. This fraction increases to ~90% if the respiratory droplets (of larger initial size) settle on a surface and then evaporate in the sessile mode.

cond-mat.soft↗

arXiv2020

Modeling ambient temperature and relative humidity sensitivity of respiratory droplets and their role in Covid-19 outbreaks

One of the many unresolved questions that revolves around the Covid-19 pandemic is whether local outbreaks can depend on ambient conditions like temperature and relative humidity. In this paper, we develop a model that tries to explain and describe the temperature and relative humidity sensitivity of respiratory droplets and their possible connection in determining viral outbreaks. The model has two parts. First, we model the growth rate of the infected population based on a reaction mechanism - the final equations of which are similar to the well-known SIR model. The advantage of modeling the pandemic using the reaction mechanism is that the rate constants have sound physical interpretation. The infection rate constant is derived using collision rate theory and shown to be a function of the respiratory droplet lifetime. In the second part, we have emulated the respiratory droplets responsible for disease transmission as salt solution droplets and computed their evaporation time accounting for droplet cooling, heat and mass transfer and finally crystallization of the salt. The model output favourably compares with the experimentally obtained evaporation characteristics of levitated droplets of pure water and salt solution, respectively, ensuring fidelity of the model. Droplet evaporation/desiccation time is indeed dependent on ambient temperature and relative humidity, considered at both outdoor and indoor conditions. Since the droplet evaporation time determines the infection rate constant, ambient temperature and relative humidity are shown to impact the outbreak growth rates.

physics.flu-dyn↗