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Qian Yan

Publications and source records attributed to Qian Yan.

4 recordsLinked to original sources

Learning Diffusions under Uncertainty

To infer a diffusion network based on observations from historical diffusion processes, existing approaches assume that observation data contain exact occurrence time of each node infection, or at least the eventual infection statuses of nodes in each diffusion process. They determine potential influence relationships between nodes by identifying frequent sequences, or statistical correlations, among node infections. In some real-world settings, such as the spread of epidemics, tracing exact infection times is often infeasible due to a high cost; even obtaining precise infection statuses of nodes is a challenging task, since observable symptoms such as headache only partially reveal a node's true status. In this work, we investigate how to effectively infer a diffusion network from observation data with uncertainty. Provided with only probabilistic information about node infection statuses, we formulate the problem of diffusion network inference as a constrained nonlinear regression w.r.t. the probabilistic data. An alternating maximization method is designed to solve this regression problem iteratively, and the improvement of solution quality in each iteration can be theoretically guaranteed. Empirical studies are conducted on both synthetic and real-world networks, and the results verify the effectiveness and efficiency of our approach.

cs.SI

Least product relative error estimation for functional multiplicative model and optimal subsampling

In this paper, we study the functional linear multiplicative model based on the least product relative error criterion. Under some regularization conditions, we establish the consistency and asymptotic normality of the estimator. Further, we investigate the optimal subsampling for this model with massive data. Both the consistency and the asymptotic distribution of the subsampling estimator are first derived. Then, we obtain the optimal subsampling probabilities based on the A-optimality criterion. Moreover, the useful alternative subsampling probabilities without computing the inverse of the Hessian matrix are also proposed, which are easier to implement in practise. Finally, numerical studies and real data analysis are done to evaluate the performance of the proposed approaches.

math.ST

Optimal subsampling for functional quantile regression

Subsampling is an efficient method to deal with massive data. In this paper, we investigate the optimal subsampling for linear quantile regression when the covariates are functions. The asymptotic distribution of the subsampling estimator is first derived. Then, we obtain the optimal subsampling probabilities based on the A-optimality criterion. Furthermore, the modified subsampling probabilities without estimating the densities of the response variables given the covariates are also proposed, which are easier to implement in practise. Numerical experiments on synthetic and real data show that the proposed methods always outperform the one with uniform sampling and can approximate the results based on full data well with less computational efforts.

math.NA

A pathway-based network analysis of hypertension-related genes

Complex network approach has become an effective way to describe interrelationships among large amounts of biological data, which is especially useful in finding core functions and global behavior of biological systems. Hypertension is a complex disease caused by many reasons including genetic, physiological, psychological and even social factors. In this paper, based on the information of biological pathways, we construct a network model of hypertension-related genes of the salt-sensitive rat to explore the interrelationship between genes. Statistical and topological characteristics show that the network has the small-world but not scale-free property, and exhibits a modular structure, revealing compact and complex connections among these genes. By the threshold of integrated centrality larger than 0.71, seven key hub genes are found: Jun, Rps6kb1, Cycs, Creb3l2, Cdk4, Actg1 and RT1-Da. These genes should play an important role in hypertension, suggesting that the treatment of hypertension should focus on the combination of drugs on multiple genes.

q-bio.MN