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Qianjin Feng

Publications and source records attributed to Qianjin Feng.

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Dual-Manifold Geometry Guided Representation Learning: Adaptive Coupling between Kernel and Data Spaces

Deep representation learning has primarily focused on how features evolve across network layers, while largely overlooking the structured geometry embedded in network parameters. We introduce a dual-manifold perspective in which each convolutional layer contains two coupled geometric spaces: a Kernel Manifold induced by convolutional filters and a Data Manifold characterized by intermediate feature representations. Because these manifolds share the same channel space, parameter geometry can provide complementary structural information to guide feature evolution. Based on this insight, we propose Kernel-Guided Feature Transform (KGFT), a lightweight module that derives a geometric guidance matrix from the kernel Gram matrix and uses it to transform the covariance structure of feature representations. Unlike conventional attention mechanisms that reweight feature responses, KGFT explicitly reshapes feature relationships by transferring geometric information from the kernel manifold to the data manifold. To accommodate network hierarchy, we further introduce Exploit and Explore modes with a depth-aware scheduling strategy and a learnable guidance strength that adaptively controls the contribution of geometric transformation. This design promotes geometric alignment in shallow layers while encouraging feature diversity in deeper layers, without imposing excessive constraints on representation learning. Theoretical analysis establishes the validity of the proposed transformation and characterizes its effect on feature covariance. Extensive experiments across CNN- and Transformer-based architectures, including ResNet, ViT, and LLaMA-7B, demonstrate consistent improvements on image classification and arithmetic reasoning tasks, validating the generality and effectiveness of kernel-guided dual-manifold representation learning. Code will be publicly available.

cs.CV

Building artificial intelligence virtual tissue (AIVT) for tissue state representation, feature prediction, and dynamic simulation

Modeling tissue states and their transitions is essential for understanding tissue homeostasis in health and pathological remodeling in disease. However, conventional computational modeling approaches are inadequate to capture the complexity of tissues as spatially organized, multiscale biological systems. Artificial intelligence (AI) has shown a remarkable ability for representing intricate systems, creating new opportunities to characterize tissue states and their transitions. Here, we propose the concept of AI virtual tissue (AIVT), an AI framework grounded in spatial multimodal data for modeling tissues in health and disease. AIVT is designed to learn unified, spatially resolved, and dynamically manipulatable representations of tissue state, enabling tissue state representation and analysis, molecular and morphological feature prediction, and simulation of spatiotemporal tissue dynamics. We outline the fundamental assumptions, core capabilities, architectural components, as well as data and algorithm foundations of AIVT as a framework for AI-driven tissue modeling.

cs.CV

MSR:Hybrid Field Modeling for CT-MRI Rigid-Deformable Registration of the Cervical Spine with an Annotated Dataset

Accurate CT-MRI registration of the cervical spine is essential for preoperative planning because this region is anatomically complex,highly variable,and vulnerable to injury of the vertebral arteries and spinal cord. However,cervical CT-MRI registration remains underexplored,particularly for rigid-deformable hybrid modeling,and the lack of high-quality annotated multimodal data further limits progress. To address these challenges, we construct and release a comprehensively annotated CT-MRI dataset, R-D-Reg, and propose MSR, a rigid-deformable hybrid registration framework for complex joint structures. Specifically, MSR includes a rigid registration module for independent local rigid alignment of individual vertebrae and a deformable registration module with an MSL block that combines Mamba-based global modeling and Swin Transformer-based local modeling through adaptive gating. The rigid and deformable deformation fields are then fused to generate a hybrid field that better preserves local anatomical consistency. The code and dataset are publicly available at https://github.com/ssc1230609-spec/MSR-registration.

cs.CV

EDU-Net: Retinal Pathological Fluid Segmentation in OCT Images with Multiscale Feature Fusion and Boundary Optimization

Objective: Diabetic macular edema (DME) is the leading cause of severe visual impairment in patients with diabetes. Quantification of retinal fluid, particularly intraretinal fluid (IRF) and subretinal fluid (SRF), plays a critical role in the management of DME. Although optical coherence tomography (OCT) can be used for detection, the variable morphology of fluid accumulation and the blurred boundaries caused by noise interference still limit the accuracy of OCT's automatic segmentation. Methods: Retrospective model development and validation study. This study proposes a novel edge-guided dual-branch encoder-decoder network (EDU-Net) to achieve accurate and efficient automatic segmentation of OCT liquid lesions. The local feature extraction branch is based on the EfficientNet model, which precisely captures tiny lesions by leveraging its lightweight separable convolution and high-resolution feature preservation strategy. The global feature extraction branch is based on the large-kernel efficient convolution (LKEC) module and the downsampling layer design to enhance long-range dependencies and global semantics. EDU-Net applies a multi-category edge-guided attention module to fuse high-frequency boundary detail information to each resolution feature to optimize the boundary segmentation performance. Results: Extensive results on the in-house and public datasets demonstrate that EDU-Net achieves state-of-the-art DSC segmentation performance in terms of efficiency and robustness, especially in the segmentation of IRF lesions. Conclusions: EDU-Net integrates local details with global context and optimizes boundaries, achieving an improvement in the accuracy of automatic segmentation of retinal fluid.

eess.IV

Cross-modal ultra-scale learning with tri-modalities of renal biopsy images for glomerular multi-disease auxiliary diagnosis

Constructing a multi-modal automatic classification model based on three types of renal biopsy images can assist pathologists in glomerular multi-disease identification. However, the substantial scale difference between transmission electron microscopy (TEM) image features at the nanoscale and optical microscopy (OM) or immunofluorescence microscopy (IM) images at the microscale poses a challenge for existing multi-modal and multi-scale models in achieving effective feature fusion and improving classification accuracy. To address this issue, we propose a cross-modal ultra-scale learning network (CMUS-Net) for the auxiliary diagnosis of multiple glomerular diseases. CMUS-Net utilizes multiple ultrastructural information to bridge the scale difference between nanometer and micrometer images. Specifically, we introduce a sparse multi-instance learning module to aggregate features from TEM images. Furthermore, we design a cross-modal scale attention module to facilitate feature interaction, enhancing pathological semantic information. Finally, multiple loss functions are combined, allowing the model to weigh the importance among different modalities and achieve precise classification of glomerular diseases. Our method follows the conventional process of renal biopsy pathology diagnosis and, for the first time, performs automatic classification of multiple glomerular diseases including IgA nephropathy (IgAN), membranous nephropathy (MN), and lupus nephritis (LN) based on images from three modalities and two scales. On an in-house dataset, CMUS-Net achieves an ACC of 95.37+/-2.41%, an AUC of 99.05+/-0.53%, and an F1-score of 95.32+/-2.41%. Extensive experiments demonstrate that CMUS-Net outperforms other well-known multi-modal or multi-scale methods and show its generalization capability in staging MN. Code is available at https://github.com/SMU-GL-Group/MultiModal_lkx/tree/main.

cs.CV

DCMIL: A Progressive Representation Learning of Whole Slide Images for Cancer Prognosis Analysis

The burgeoning discipline of computational pathology shows promise in harnessing whole slide images (WSIs) to quantify morphological heterogeneity and develop objective prognostic modes for human cancers. However, progress is impeded by the computational bottleneck of gigapixel-size inputs and the scarcity of dense manual annotations. Current methods often overlook fine-grained information across multi-magnification WSIs and variations in tumor microenvironments. Here, we propose an easy-to-hard progressive representation learning, termed dual-curriculum contrastive multi-instance learning (DCMIL), to efficiently process WSIs for cancer prognosis. The model does not rely on dense annotations and enables the direct transformation of gigapixel-size WSIs into outcome predictions. Extensive experiments on twelve cancer types (5,954 patients, 12.54 million tiles) demonstrate that DCMIL outperforms standard WSI-based prognostic models. Additionally, DCMIL identifies fine-grained prognosis-salient regions, provides robust instance uncertainty estimation, and captures morphological differences between normal and tumor tissues, with the potential to generate new biological insights. All codes have been made publicly accessible at https://github.com/tuuuc/DCMIL.

cs.CV

FSDA-DG: Improving Cross-Domain Generalizability of Medical Image Segmentation with Few Source Domain Annotations

Deep learning-based medical image segmentation faces significant challenges arising from limited labeled data and domain shifts. While prior approaches have primarily addressed these issues independently, their simultaneous occurrence is common in medical imaging. A method that generalizes to unseen domains using only minimal annotations offers significant practical value due to reduced data annotation and development costs. In pursuit of this goal, we propose FSDA-DG, a novel solution to improve cross-domain generalizability of medical image segmentation with few single-source domain annotations. Specifically, our approach introduces semantics-guided semi-supervised data augmentation. This method divides images into global broad regions and semantics-guided local regions, and applies distinct augmentation strategies to enrich data distribution. Within this framework, both labeled and unlabeled data are transformed into extensive domain knowledge while preserving domain-invariant semantic information. Additionally, FSDA-DG employs a multi-decoder U-Net pipeline semi-supervised learning (SSL) network to improve domain-invariant representation learning through consistent prior assumption across multiple perturbations. By integrating data-level and model-level designs, FSDA-DG achieves superior performance compared to state-of-the-art methods in two challenging single domain generalization (SDG) tasks with limited annotations. The code is publicly available at https://github.com/yezanting/FSDA-DG.

cs.CV

Medical Image Fusion for High-Level Analysis: A Mutual Enhancement Framework for Unaligned PAT and MRI

Photoacoustic tomography (PAT) offers optical contrast, whereas magnetic resonance imaging (MRI) excels in imaging soft tissue and organ anatomy. The fusion of PAT with MRI holds promising application prospects due to their complementary advantages. Existing image fusion have made considerable progress in pre-registered images, yet spatial deformations are difficult to avoid in medical imaging scenarios. More importantly, current algorithms focus on visual quality and statistical metrics, thus overlooking the requirements of high-level tasks. To address these challenges, we propose an unsupervised fusion model, termed PAMRFuse+, which integrates image generation and registration. Specifically, a cross-modal style transfer network is introduced to simplify cross-modal registration to single-modal registration. Subsequently, a multi-level registration network is employed to predict displacement vector fields. Furthermore, a dual-branch feature decomposition fusion network is proposed to address the challenges of cross-modal feature modeling and decomposition by integrating modality-specific and modality-shared features. PAMRFuse+ achieves satisfactory results in registering and fusing unaligned PAT-MRI datasets. Moreover, for the first time, we evaluate the performance of medical image fusion with multi-organ instance segmentation. Extensive experimental demonstrations reveal the advantages of PAMRFuse+ in improving the performance of medical image analysis tasks.

eess.IV

SpineMamba: Enhancing 3D Spinal Segmentation in Clinical Imaging through Residual Visual Mamba Layers and Shape Priors

Accurate segmentation of 3D clinical medical images is critical in the diagnosis and treatment of spinal diseases. However, the inherent complexity of spinal anatomy and uncertainty inherent in current imaging technologies, poses significant challenges for semantic segmentation of spinal images. Although convolutional neural networks (CNNs) and Transformer-based models have made some progress in spinal segmentation, their limitations in handling long-range dependencies hinder further improvements in segmentation accuracy.To address these challenges, we introduce a residual visual Mamba layer to effectively capture and model the deep semantic features and long-range spatial dependencies of 3D spinal data. To further enhance the structural semantic understanding of the vertebrae, we also propose a novel spinal shape prior module that captures specific anatomical information of the spine from medical images, significantly enhancing the model's ability to extract structural semantic information of the vertebrae. Comparative and ablation experiments on two datasets demonstrate that SpineMamba outperforms existing state-of-the-art models. On the CT dataset, the average Dice similarity coefficient for segmentation reaches as high as 94.40, while on the MR dataset, it reaches 86.95. Notably, compared to the renowned nnU-Net, SpineMamba achieves superior segmentation performance, exceeding it by up to 2 percentage points. This underscores its accuracy, robustness, and excellent generalization capabilities.

eess.IV

A multi-stage semi-supervised learning for ankle fracture classification on CT images

Because of the complicated mechanism of ankle injury, it is very difficult to diagnose ankle fracture in clinic. In order to simplify the process of fracture diagnosis, an automatic diagnosis model of ankle fracture was proposed. Firstly, a tibia-fibula segmentation network is proposed for the joint tibiofibular region of the ankle joint, and the corresponding segmentation dataset is established on the basis of fracture data. Secondly, the image registration method is used to register the bone segmentation mask with the normal bone mask. Finally, a semi-supervised classifier is constructed to make full use of a large number of unlabeled data to classify ankle fractures. Experiments show that the proposed method can segment fractures with fracture lines accurately and has better performance than the general method. At the same time, this method is superior to classification network in several indexes.

eess.IV

Decomposing and Coupling Saliency Map for Lesion Segmentation in Ultrasound Images

Complex scenario of ultrasound image, in which adjacent tissues (i.e., background) share similar intensity with and even contain richer texture patterns than lesion region (i.e., foreground), brings a unique challenge for accurate lesion segmentation. This work presents a decomposition-coupling network, called DC-Net, to deal with this challenge in a (foreground-background) saliency map disentanglement-fusion manner. The DC-Net consists of decomposition and coupling subnets, and the former preliminarily disentangles original image into foreground and background saliency maps, followed by the latter for accurate segmentation under the assistance of saliency prior fusion. The coupling subnet involves three aspects of fusion strategies, including: 1) regional feature aggregation (via differentiable context pooling operator in the encoder) to adaptively preserve local contextual details with the larger receptive field during dimension reduction; 2) relation-aware representation fusion (via cross-correlation fusion module in the decoder) to efficiently fuse low-level visual characteristics and high-level semantic features during resolution restoration; 3) dependency-aware prior incorporation (via coupler) to reinforce foreground-salient representation with the complementary information derived from background representation. Furthermore, a harmonic loss function is introduced to encourage the network to focus more attention on low-confidence and hard samples. The proposed method is evaluated on two ultrasound lesion segmentation tasks, which demonstrates the remarkable performance improvement over existing state-of-the-art methods.

eess.IV

Multi-View Imputation and Cross-Attention Network Based on Incomplete Longitudinal and Multimodal Data for Conversion Prediction of Mild Cognitive Impairment

Predicting whether subjects with mild cognitive impairment (MCI) will convert to Alzheimer's disease is a significant clinical challenge. Longitudinal variations and complementary information inherent in longitudinal and multimodal data are crucial for MCI conversion prediction, but persistent issue of missing data in these data may hinder their effective application. Additionally, conversion prediction should be achieved in the early stages of disease progression in clinical practice, specifically at baseline visit (BL). Therefore, longitudinal data should only be incorporated during training to capture disease progression information. To address these challenges, a multi-view imputation and cross-attention network (MCNet) was proposed to integrate data imputation and MCI conversion prediction in a unified framework. First, a multi-view imputation method combined with adversarial learning was presented to handle various missing data scenarios and reduce imputation errors. Second, two cross-attention blocks were introduced to exploit the potential associations in longitudinal and multimodal data. Finally, a multi-task learning model was established for data imputation, longitudinal classification, and conversion prediction tasks. When the model was appropriately trained, the disease progression information learned from longitudinal data can be leveraged by BL data to improve MCI conversion prediction at BL. MCNet was tested on two independent testing sets and single-modal BL data to verify its effectiveness and flexibility in MCI conversion prediction. Results showed that MCNet outperformed several competitive methods. Moreover, the interpretability of MCNet was demonstrated. Thus, our MCNet may be a valuable tool in longitudinal and multimodal data analysis for MCI conversion prediction. Codes are available at https://github.com/Meiyan88/MCNET.

eess.IV

Semi-Supervised Hybrid Spine Network for Segmentation of Spine MR Images

Automatic segmentation of vertebral bodies (VBs) and intervertebral discs (IVDs) in 3D magnetic resonance (MR) images is vital in diagnosing and treating spinal diseases. However, segmenting the VBs and IVDs simultaneously is not trivial. Moreover, problems exist, including blurry segmentation caused by anisotropy resolution, high computational cost, inter-class similarity and intra-class variability, and data imbalances. We proposed a two-stage algorithm, named semi-supervised hybrid spine network (SSHSNet), to address these problems by achieving accurate simultaneous VB and IVD segmentation. In the first stage, we constructed a 2D semi-supervised DeepLabv3+ by using cross pseudo supervision to obtain intra-slice features and coarse segmentation. In the second stage, a 3D full-resolution patch-based DeepLabv3+ was built. This model can be used to extract inter-slice information and combine the coarse segmentation and intra-slice features provided from the first stage. Moreover, a cross tri-attention module was applied to compensate for the loss of inter-slice and intra-slice information separately generated from 2D and 3D networks, thereby improving feature representation ability and achieving satisfactory segmentation results. The proposed SSHSNet was validated on a publicly available spine MR image dataset, and remarkable segmentation performance was achieved. Moreover, results show that the proposed method has great potential in dealing with the data imbalance problem. Based on previous reports, few studies have incorporated a semi-supervised learning strategy with a cross attention mechanism for spine segmentation. Therefore, the proposed method may provide a useful tool for spine segmentation and aid clinically in spinal disease diagnoses and treatments. Codes are publicly available at: https://github.com/Meiyan88/SSHSNet.

eess.IV

Unsupervised Deformable Medical Image Registration via Pyramidal Residual Deformation Fields Estimation

Deformation field estimation is an important and challenging issue in many medical image registration applications. In recent years, deep learning technique has become a promising approach for simplifying registration problems, and has been gradually applied to medical image registration. However, most existing deep learning registrations do not consider the problem that when the receptive field cannot cover the corresponding features in the moving image and the fixed image, it cannot output accurate displacement values. In fact, due to the limitation of the receptive field, the 3 x 3 kernel has difficulty in covering the corresponding features at high/original resolution. Multi-resolution and multi-convolution techniques can improve but fail to avoid this problem. In this study, we constructed pyramidal feature sets on moving and fixed images and used the warped moving and fixed features to estimate their "residual" deformation field at each scale, called the Pyramidal Residual Deformation Field Estimation module (PRDFE-Module). The "total" deformation field at each scale was computed by upsampling and weighted summing all the "residual" deformation fields at all its previous scales, which can effectively and accurately transfer the deformation fields from low resolution to high resolution and is used for warping the moving features at each scale. Simulation and real brain data results show that our method improves the accuracy of the registration and the rationality of the deformation field.

cs.CV

CF2-Net: Coarse-to-Fine Fusion Convolutional Network for Breast Ultrasound Image Segmentation

Breast ultrasound (BUS) image segmentation plays a crucial role in a computer-aided diagnosis system, which is regarded as a useful tool to help increase the accuracy of breast cancer diagnosis. Recently, many deep learning methods have been developed for segmentation of BUS image and show some advantages compared with conventional region-, model-, and traditional learning-based methods. However, previous deep learning methods typically use skip-connection to concatenate the encoder and decoder, which might not make full fusion of coarse-to-fine features from encoder and decoder. Since the structure and edge of lesion in BUS image are common blurred, these would make it difficult to learn the discriminant information of structure and edge, and reduce the performance. To this end, we propose and evaluate a coarse-to-fine fusion convolutional network (CF2-Net) based on a novel feature integration strategy (forming an 'E'-like type) for BUS image segmentation. To enhance contour and provide structural information, we concatenate a super-pixel image and the original image as the input of CF2-Net. Meanwhile, to highlight the differences in the lesion regions with variable sizes and relieve the imbalance issue, we further design a weighted-balanced loss function to train the CF2-Net effectively. The proposed CF2-Net was evaluated on an open dataset by using four-fold cross validation. The results of the experiment demonstrate that the CF2-Net obtains state-of-the-art performance when compared with other deep learning-based methods

eess.IV

Cross-lingual Data Transformation and Combination for Text Classification

Text classification is a fundamental task for text data mining. In order to train a generalizable model, a large volume of text must be collected. To address data insufficiency, cross-lingual data may occasionally be necessary. Cross-lingual data sources may however suffer from data incompatibility, as text written in different languages can hold distinct word sequences and semantic patterns. Machine translation and word embedding alignment provide an effective way to transform and combine data for cross-lingual data training. To the best of our knowledge, there has been little work done on evaluating how the methodology used to conduct semantic space transformation and data combination affects the performance of classification models trained from cross-lingual resources. In this paper, we systematically evaluated the performance of two commonly used CNN (Convolutional Neural Network) and RNN (Recurrent Neural Network) text classifiers with differing data transformation and combination strategies. Monolingual models were trained from English and French alongside their translated and aligned embeddings. Our results suggested that semantic space transformation may conditionally promote the performance of monolingual models. Bilingual models were trained from a combination of both English and French. Our results indicate that a cross-lingual classification model can significantly benefit from cross-lingual data by learning from translated or aligned embedding spaces.

cs.IR

Direct Automated Quantitative Measurement of Spine via Cascade Amplifier Regression Network

Automated quantitative measurement of the spine (i.e., multiple indices estimation of heights, widths, areas, and so on for the vertebral body and disc) is of the utmost importance in clinical spinal disease diagnoses, such as osteoporosis, intervertebral disc degeneration, and lumbar disc herniation, yet still an unprecedented challenge due to the variety of spine structure and the high dimensionality of indices to be estimated. In this paper, we propose a novel cascade amplifier regression network (CARN), which includes the CARN architecture and local shape-constrained manifold regularization (LSCMR) loss function, to achieve accurate direct automated multiple indices estimation. The CARN architecture is composed of a cascade amplifier network (CAN) for expressive feature embedding and a linear regression model for multiple indices estimation. The CAN consists of cascade amplifier units (AUs), which are used for selective feature reuse by stimulating effective feature and suppressing redundant feature during propagating feature map between adjacent layers, thus an expressive feature embedding is obtained. During training, the LSCMR is utilized to alleviate overfitting and generate realistic estimation by learning the multiple indices distribution. Experiments on MR images of 195 subjects show that the proposed CARN achieves impressive performance with mean absolute errors of 1.2496 mm, 1.2887 mm, and 1.2692 mm for estimation of 15 heights of discs, 15 heights of vertebral bodies, and total indices respectively. The proposed method has great potential in clinical spinal disease diagnoses.

cs.CV