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Qianni Zhang

Publications and source records attributed to Qianni Zhang.

35 records · Page 2Linked to original sources

Deep Learning Based Brain Tumor Segmentation: A Survey

Brain tumor segmentation is one of the most challenging problems in medical image analysis. The goal of brain tumor segmentation is to generate accurate delineation of brain tumor regions. In recent years, deep learning methods have shown promising performance in solving various computer vision problems, such as image classification, object detection and semantic segmentation. A number of deep learning based methods have been applied to brain tumor segmentation and achieved promising results. Considering the remarkable breakthroughs made by state-of-the-art technologies, we use this survey to provide a comprehensive study of recently developed deep learning based brain tumor segmentation techniques. More than 100 scientific papers are selected and discussed in this survey, extensively covering technical aspects such as network architecture design, segmentation under imbalanced conditions, and multi-modality processes. We also provide insightful discussions for future development directions.

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AGMB-Transformer: Anatomy-Guided Multi-Branch Transformer Network for Automated Evaluation of Root Canal Therapy

Accurate evaluation of the treatment result on X-ray images is a significant and challenging step in root canal therapy since the incorrect interpretation of the therapy results will hamper timely follow-up which is crucial to the patients' treatment outcome. Nowadays, the evaluation is performed in a manual manner, which is time-consuming, subjective, and error-prone. In this paper, we aim to automate this process by leveraging the advances in computer vision and artificial intelligence, to provide an objective and accurate method for root canal therapy result assessment. A novel anatomy-guided multi-branch Transformer (AGMB-Transformer) network is proposed, which first extracts a set of anatomy features and then uses them to guide a multi-branch Transformer network for evaluation. Specifically, we design a polynomial curve fitting segmentation strategy with the help of landmark detection to extract the anatomy features. Moreover, a branch fusion module and a multi-branch structure including our progressive Transformer and Group Multi-Head Self-Attention (GMHSA) are designed to focus on both global and local features for an accurate diagnosis. To facilitate the research, we have collected a large-scale root canal therapy evaluation dataset with 245 root canal therapy X-ray images, and the experiment results show that our AGMB-Transformer can improve the diagnosis accuracy from 57.96% to 90.20% compared with the baseline network. The proposed AGMB-Transformer can achieve a highly accurate evaluation of root canal therapy. To our best knowledge, our work is the first to perform automatic root canal therapy evaluation and has important clinical value to reduce the workload of endodontists.

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Dispensed Transformer Network for Unsupervised Domain Adaptation

Accurate segmentation is a crucial step in medical image analysis and applying supervised machine learning to segment the organs or lesions has been substantiated effective. However, it is costly to perform data annotation that provides ground truth labels for training the supervised algorithms, and the high variance of data that comes from different domains tends to severely degrade system performance over cross-site or cross-modality datasets. To mitigate this problem, a novel unsupervised domain adaptation (UDA) method named dispensed Transformer network (DTNet) is introduced in this paper. Our novel DTNet contains three modules. First, a dispensed residual transformer block is designed, which realizes global attention by dispensed interleaving operation and deals with the excessive computational cost and GPU memory usage of the Transformer. Second, a multi-scale consistency regularization is proposed to alleviate the loss of details in the low-resolution output for better feature alignment. Finally, a feature ranking discriminator is introduced to automatically assign different weights to domain-gap features to lessen the feature distribution distance, reducing the performance shift of two domains. The proposed method is evaluated on large fluorescein angiography (FA) retinal nonperfusion (RNP) cross-site dataset with 676 images and a wide used cross-modality dataset from the MM-WHS challenge. Extensive results demonstrate that our proposed network achieves the best performance in comparison with several state-of-the-art techniques.

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GT U-Net: A U-Net Like Group Transformer Network for Tooth Root Segmentation

To achieve an accurate assessment of root canal therapy, a fundamental step is to perform tooth root segmentation on oral X-ray images, in that the position of tooth root boundary is significant anatomy information in root canal therapy evaluation. However, the fuzzy boundary makes the tooth root segmentation very challenging. In this paper, we propose a novel end-to-end U-Net like Group Transformer Network (GT U-Net) for the tooth root segmentation. The proposed network retains the essential structure of U-Net but each of the encoders and decoders is replaced by a group Transformer, which significantly reduces the computational cost of traditional Transformer architectures by using the grouping structure and the bottleneck structure. In addition, the proposed GT U-Net is composed of a hybrid structure of convolution and Transformer, which makes it independent of pre-training weights. For optimization, we also propose a shape-sensitive Fourier Descriptor (FD) loss function to make use of shape prior knowledge. Experimental results show that our proposed network achieves the state-of-the-art performance on our collected tooth root segmentation dataset and the public retina dataset DRIVE. Code has been released at https://github.com/Kent0n-Li/GT-U-Net.

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Structure-aware scale-adaptive networks for cancer segmentation in whole-slide images

Cancer segmentation in whole-slide images is a fundamental step for viable tumour burden estimation, which is of great value for cancer assessment. However, factors like vague boundaries or small regions dissociated from viable tumour areas make it a challenging task. Considering the usefulness of multi-scale features in various vision-related tasks, we present a structure-aware scale-adaptive feature selection method for efficient and accurate cancer segmentation. Based on a segmentation network with a popular encoder-decoder architecture, a scale-adaptive module is proposed for selecting more robust features to represent the vague, non-rigid boundaries. Furthermore, a structural similarity metric is proposed for better tissue structure awareness to deal with small region segmentation. In addition, advanced designs including several attention mechanisms and the selective-kernel convolutions are applied to the baseline network for comparative study purposes. Extensive experimental results show that the proposed structure-aware scale-adaptive networks achieve outstanding performance on liver cancer segmentation when compared to top ten submitted results in the challenge of PAIP 2019. Further evaluation on colorectal cancer segmentation shows that the scale-adaptive module improves the baseline network or outperforms the other excellent designs of attention mechanisms when considering the tradeoff between efficiency and accuracy.

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SRPN: similarity-based region proposal networks for nuclei and cells detection in histology images

The detection of nuclei and cells in histology images is of great value in both clinical practice and pathological studies. However, multiple reasons such as morphological variations of nuclei or cells make it a challenging task where conventional object detection methods cannot obtain satisfactory performance in many cases. A detection task consists of two sub-tasks, classification and localization. Under the condition of dense object detection, classification is a key to boost the detection performance. Considering this, we propose similarity based region proposal networks (SRPN) for nuclei and cells detection in histology images. In particular, a customized convolution layer termed as embedding layer is designed for network building. The embedding layer is added into the region proposal networks, enabling the networks to learn discriminative features based on similarity learning. Features obtained by similarity learning can significantly boost the classification performance compared to conventional methods. SRPN can be easily integrated into standard convolutional neural networks architectures such as the Faster R-CNN and RetinaNet. We test the proposed approach on tasks of multi-organ nuclei detection and signet ring cells detection in histological images. Experimental results show that networks applying similarity learning achieved superior performance on both tasks when compared to their counterparts. In particular, the proposed SRPN achieve state-of-the-art performance on the MoNuSeg benchmark for nuclei segmentation and detection while compared to previous methods, and on the signet ring cell detection benchmark when compared with baselines. The sourcecode is publicly available at: https://github.com/sigma10010/nuclei_cells_det.

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High-Resolution Segmentation of Tooth Root Fuzzy Edge Based on Polynomial Curve Fitting with Landmark Detection

As the most economical and routine auxiliary examination in the diagnosis of root canal treatment, oral X-ray has been widely used by stomatologists. It is still challenging to segment the tooth root with a blurry boundary for the traditional image segmentation method. To this end, we propose a model for high-resolution segmentation based on polynomial curve fitting with landmark detection (HS-PCL). It is based on detecting multiple landmarks evenly distributed on the edge of the tooth root to fit a smooth polynomial curve as the segmentation of the tooth root, thereby solving the problem of fuzzy edge. In our model, a maximum number of the shortest distances algorithm (MNSDA) is proposed to automatically reduce the negative influence of the wrong landmarks which are detected incorrectly and deviate from the tooth root on the fitting result. Our numerical experiments demonstrate that the proposed approach not only reduces Hausdorff95 (HD95) by 33.9% and Average Surface Distance (ASD) by 42.1% compared with the state-of-the-art method, but it also achieves excellent results on the minute quantity of datasets, which greatly improves the feasibility of automatic root canal therapy evaluation by medical image computing.

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CANet: Context Aware Network for 3D Brain Glioma Segmentation

Automated segmentation of brain glioma plays an active role in diagnosis decision, progression monitoring and surgery planning. Based on deep neural networks, previous studies have shown promising technologies for brain glioma segmentation. However, these approaches lack powerful strategies to incorporate contextual information of tumor cells and their surrounding, which has been proven as a fundamental cue to deal with local ambiguity. In this work, we propose a novel approach named Context-Aware Network (CANet) for brain glioma segmentation. CANet captures high dimensional and discriminative features with contexts from both the convolutional space and feature interaction graphs. We further propose context guided attentive conditional random fields which can selectively aggregate features. We evaluate our method using publicly accessible brain glioma segmentation datasets BRATS2017, BRATS2018 and BRATS2019. The experimental results show that the proposed algorithm has better or competitive performance against several State-of-The-Art approaches under different segmentation metrics on the training and validation sets.

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Multimodal Gait Recognition for Neurodegenerative Diseases

In recent years, single modality based gait recognition has been extensively explored in the analysis of medical images or other sensory data, and it is recognised that each of the established approaches has different strengths and weaknesses. As an important motor symptom, gait disturbance is usually used for diagnosis and evaluation of diseases; moreover, the use of multi-modality analysis of the patient's walking pattern compensates for the one-sidedness of single modality gait recognition methods that only learn gait changes in a single measurement dimension. The fusion of multiple measurement resources has demonstrated promising performance in the identification of gait patterns associated with individual diseases. In this paper, as a useful tool, we propose a novel hybrid model to learn the gait differences between three neurodegenerative diseases, between patients with different severity levels of Parkinson's disease and between healthy individuals and patients, by fusing and aggregating data from multiple sensors. A spatial feature extractor (SFE) is applied to generating representative features of images or signals. In order to capture temporal information from the two modality data, a new correlative memory neural network (CorrMNN) architecture is designed for extracting temporal features. Afterwards, we embed a multi-switch discriminator to associate the observations with individual state estimations. Compared with several state-of-the-art techniques, our proposed framework shows more accurate classification results.

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Convolutional Recurrent Residual U-Net Embedded with Attention Mechanism and Focal Tversky Loss Function for Cancerous Nuclei Detection

Since the beginning of this decade, CNN has been a very successful tool in the field of Computer Vision tasks.The invention of CNN was inspired from neuroscience and it shares a lot of anatomical similarities with our visual system.Inspired by the anatomyof humanvisual system, wearguethat the existing U-Net architecture can be improvedin many ways. As human visual system uses attention mechanism, we have used attention concatenation in place of normalconcatenation.Although, CNN is purely feed-forward in nature but anatomical evidences show that our brain contains recurrent synapses and they often outnumber feed-forward and top-down connections. Thisfact inspiresus to userecurrent convolution connectionsin place of normalconvolution blocksin U-Net.Thispaper also addressesthe class imbalance issuein the field of medical image analysis. The paperresolvestheproblem of class imbalanceswith the help of state-of-the-art loss functions.Weargue thatourproposed architecturecan be trained end to end with a few training data and it outperforms the other variantsof U-Net.

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Perceptual underwater image enhancement with deep learning and physical priors

Underwater image enhancement, as a pre-processing step to improve the accuracy of the following object detection task, has drawn considerable attention in the field of underwater navigation and ocean exploration. However, most of the existing underwater image enhancement strategies tend to consider enhancement and detection as two independent modules with no interaction, and the practice of separate optimization does not always help the underwater object detection task. In this paper, we propose two perceptual enhancement models, each of which uses a deep enhancement model with a detection perceptor. The detection perceptor provides coherent information in the form of gradients to the enhancement model, guiding the enhancement model to generate patch level visually pleasing images or detection favourable images. In addition, due to the lack of training data, a hybrid underwater image synthesis model, which fuses physical priors and data-driven cues, is proposed to synthesize training data and generalise our enhancement model for real-world underwater images. Experimental results show the superiority of our proposed method over several state-of-the-art methods on both real-world and synthetic underwater datasets.

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Deep Learning Methods for Lung Cancer Segmentation in Whole-slide Histopathology Images -- the ACDC@LungHP Challenge 2019

Accurate segmentation of lung cancer in pathology slides is a critical step in improving patient care. We proposed the ACDC@LungHP (Automatic Cancer Detection and Classification in Whole-slide Lung Histopathology) challenge for evaluating different computer-aided diagnosis (CADs) methods on the automatic diagnosis of lung cancer. The ACDC@LungHP 2019 focused on segmentation (pixel-wise detection) of cancer tissue in whole slide imaging (WSI), using an annotated dataset of 150 training images and 50 test images from 200 patients. This paper reviews this challenge and summarizes the top 10 submitted methods for lung cancer segmentation. All methods were evaluated using the false positive rate, false negative rate, and DICE coefficient (DC). The DC ranged from 0.7354$\pm$0.1149 to 0.8372$\pm$0.0858. The DC of the best method was close to the inter-observer agreement (0.8398$\pm$0.0890). All methods were based on deep learning and categorized into two groups: multi-model method and single model method. In general, multi-model methods were significantly better ($\textit{p}$<$0.01$) than single model methods, with mean DC of 0.7966 and 0.7544, respectively. Deep learning based methods could potentially help pathologists find suspicious regions for further analysis of lung cancer in WSI.

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US-net for robust and efficient nuclei instance segmentation

We present a novel neural network architecture, US-Net, for robust nuclei instance segmentation in histopathology images. The proposed framework integrates the nuclei detection and segmentation networks by sharing their outputs through the same foundation network, and thus enhancing the performance of both. The detection network takes into account the high-level semantic cues with contextual information, while the segmentation network focuses more on the low-level details like the edges. Extensive experiments reveal that our proposed framework can strengthen the performance of both branch networks in an integrated architecture and outperforms most of the state-of-the-art nuclei detection and segmentation networks.

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Multilevel active registration for kinect human body scans: from low quality to high quality

Registration of 3D human body has been a challenging research topic for over decades. Most of the traditional human body registration methods require manual assistance, or other auxiliary information such as texture and markers. The majority of these methods are tailored for high-quality scans from expensive scanners. Following the introduction of the low-quality scans from cost-effective devices such as Kinect, the 3D data capturing of human body becomes more convenient and easier. However, due to the inevitable holes, noises and outliers in the low-quality scan, the registration of human body becomes even more challenging. To address this problem, we propose a fully automatic active registration method which deforms a high-resolution template mesh to match the low-quality human body scans. Our registration method operates on two levels of statistical shape models: (1) the first level is a holistic body shape model that defines the basic figure of human; (2) the second level includes a set of shape models for every body part, aiming at capturing more body details. Our fitting procedure follows a coarse-to-fine approach that is robust and efficient. Experiments show that our method is comparable with the state-of-the-art methods.

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CUNet: A Compact Unsupervised Network for Image Classification

In this paper, we propose a compact network called CUNet (compact unsupervised network) to counter the image classification challenge. Different from the traditional convolutional neural networks learning filters by the time-consuming stochastic gradient descent, CUNet learns the filter bank from diverse image patches with the simple K-means, which significantly avoids the requirement of scarce labeled training images, reduces the training consumption, and maintains the high discriminative ability. Besides, we propose a new pooling method named weighted pooling considering the different weight values of adjacent neurons, which helps to improve the robustness to small image distortions. In the output layer, CUNet integrates the feature maps gained in the last hidden layer, and straightforwardly computes histograms in non-overlapped blocks. To reduce feature redundancy, we implement the max-pooling operation on adjacent blocks to select the most competitive features. Comprehensive experiments are conducted to demonstrate the state-of-the-art classification performances with CUNet on CIFAR-10, STL-10, MNIST and Caltech101 benchmark datasets.

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NIST: An Image Classification Network to Image Semantic Retrieval

This paper proposes a classification network to image semantic retrieval (NIST) framework to counter the image retrieval challenge. Our approach leverages the successful classification network GoogleNet based on Convolutional Neural Networks to obtain the semantic feature matrix which contains the serial number of classes and corresponding probabilities. Compared with traditional image retrieval using feature matching to compute the similarity between two images, NIST leverages the semantic information to construct semantic feature matrix and uses the semantic distance algorithm to compute the similarity. Besides, the fusion strategy can significantly reduce storage and time consumption due to less classes participating in the last semantic distance computation. Experiments demonstrate that our NIST framework produces state-of-the-art results in retrieval experiments on MIRFLICKR-25K dataset.

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A Distributed Deep Representation Learning Model for Big Image Data Classification

This paper describes an effective and efficient image classification framework nominated distributed deep representation learning model (DDRL). The aim is to strike the balance between the computational intensive deep learning approaches (tuned parameters) which are intended for distributed computing, and the approaches that focused on the designed parameters but often limited by sequential computing and cannot scale up. In the evaluation of our approach, it is shown that DDRL is able to achieve state-of-art classification accuracy efficiently on both medium and large datasets. The result implies that our approach is more efficient than the conventional deep learning approaches, and can be applied to big data that is too complex for parameter designing focused approaches. More specifically, DDRL contains two main components, i.e., feature extraction and selection. A hierarchical distributed deep representation learning algorithm is designed to extract image statistics and a nonlinear mapping algorithm is used to map the inherent statistics into abstract features. Both algorithms are carefully designed to avoid millions of parameters tuning. This leads to a more compact solution for image classification of big data. We note that the proposed approach is designed to be friendly with parallel computing. It is generic and easy to be deployed to different distributed computing resources. In the experiments, the largescale image datasets are classified with a DDRM implementation on Hadoop MapReduce, which shows high scalability and resilience.

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