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Qiao Jin

Publications and source records attributed to Qiao Jin.

At least 19 recordsLinked to original sources
arXiv2026

When Single-User-Oriented LLM-based Assistants Involve Others: A Scoping Review of Pathways, Risks, and Responses

LLM-based assistants are increasingly extending into multi-party contexts, while core operational processes for context management, personalization, identity attribution, authority attribution, and action execution often remain organized around a single user. Existing work examines particular multi-party settings, but lacks a systematic account of how these single-user-oriented assistants begin to involve additional human parties and what risks emerge. To address this gap, we conducted a scoping review of 58 studies. We identify five operational pathways spanning direct and indirect involvement, five recurring risk domains, and five areas of implemented and proposed responses. Based on these findings, we argue for governance that attends to changing cross-person roles and relationships in practice, and for assistant designs that preserve person-specific boundaries throughout interaction.

cs.HC↗
arXiv2026

Towards AI-Assisted Clinical Trial Matching: Practical Considerations, Multicenter Evaluation, and Real-World Deployment

Clinical trials are essential for advancing cancer care and drug development, but many fail because of insufficient patient enrollment. While there is growing interest in using AI to support patient recruitment, existing systems largely perform eligibility assessment alone and have rarely been evaluated in real-world oncology workflows. Here we present TrialGPT 2.0, an AI-assisted clinical trial recommendation system designed for real-world deployment. Rather than asking only whether a patient may qualify, the system also assesses which trials warrant further consideration given the patient's current clinical needs and local workflow priorities, and provides structured, inspectable explanations for expert review. Importantly, we evaluated TrialGPT 2.0 retrospectively and prospectively across multiple oncology-focused settings, spanning government, academic cancer-center, patient-advocacy, and NIH referral workflows. In retrospective multicenter cohorts comprising 288 cases, TrialGPT 2.0 retrieved at least one clinician-recommended trial in its top 10 recommendations for approximately 91% of cases while reducing clinician screening time by 55.0%. In a six-month prospective evaluation embedded in an active precision oncology tumor board, TrialGPT 2.0 contributed additional trial opportunities missed by the routine workflow, expanding patient access to clinical trial participation by 90.9%. To support scientific reproducibility, we also introduce NIH-TrialBench, a clinician-authored dataset comprising 126 diverse synthetic patient vignettes and matching scenarios from 11 NIH Institutes and Centers. Together, these results support the value of AI to assist clinical trial matching by improving clinician efficiency and identifying frequently overlooked trial opportunities, ultimately helping to expand and accelerate accrual to cancer trials.

cs.CL↗
arXiv2026

Context or Digits? Balancing Memorability and Efficiency in Virtual Reality Authentication

We present Adaptive Direction-Based Authentication (ADBA), a knowledge-based authentication method for Virtual Reality that decouples users' needs temporally by enforcing password creation based on virtual environment context while supporting both context- and digit-based entries during authentication. This design prioritizes memorability for new passwords and offers both efficient and memorable options to support users' evolving needs. We conducted a remote longitudinal study with 66 participants comparing ADBA against 6-digit PINs over 2-3 weeks. The results demonstrated that ADBA achieved superior memorability and lower perceived task load. Interestingly, no participant chose to enter via digits in the study, yet they still perceived ADBA to be highly efficiency despite longer objective entry times. ADBA also provided security benefits through randomly-generated digit representations, though some degree of password homogeneity was observed in specific virtual environments. Our findings suggest that ADBA offers solid advantages to the traditional PINs, and successfully addresses the tradeoffs between efficiency, memorability, and security under the usage scenarios considered in the study.

cs.CR↗
arXiv2026

Do AI chatbots find what experts would? Effects of model, user role, and sample size on study retrieval for medical questions

Large language model (LLM) chatbots are increasingly used to answer clinical questions with citations to relevant clinical studies. Prior research has largely focused on citation fabrication, leaving a gap in evaluating the quality of retrieved studies and the factors driving their selection. In this study, we evaluated three general-purpose LLM chatbots: Claude Sonnet 5, Gemini 3.1 Pro, and ChatGPT GPT-5.5. We prompted the models with clinical questions adapted from 20 review questions in Issues 6 and 7 of the 2026 Cochrane Database of Systematic Reviews, simulating patient, clinician, and evidence-synthesis researcher roles. Each chatbot was queried under each user role with four independent repetitions, yielding 720 responses. Each chatbot was asked to support its answers with primary clinical citations, which we benchmarked against the included and excluded study sets of the Cochrane reviews. On average, a chatbot response retrieved 39.2% $\pm$ 29.8% of Cochrane included studies, while citing 5.0% $\pm$ 9.4% of excluded studies. Recall of Cochrane included studies varied significantly by model and user role. ChatGPT achieved higher recall than Claude or Gemini (63.1% $\pm$ 29.5% vs. 37.0% $\pm$ 23.8% vs. 17.3% $\pm$ 13.1%; $p=2.0\times10^{-5}$). The researcher role yielded higher recall than the clinician or patient roles (42.8% $\pm$ 30.8% vs. 38.6% $\pm$ 28.9% vs. 36.1% $\pm$ 29.3%; $p=2.0\times10^{-5}$). Controlling for publication year, citations per year, and open-access status, sample size was the only independently significant predictor of retrieval (odds ratio 1.80 per 1-unit increase in log sample size, 95% CI 1.37-2.36, $p=2.34\times10^{-5}$). These findings suggest that while LLM chatbots can retrieve some studies identified by expert reviewers, their performance varies by model and user role, and they exhibit a bias toward clinical trials with larger sample sizes.

cs.IR↗
arXiv2026

"If I Can See You": Understanding Spatially Situated Virtual Embodiment in Close Human-AI Relationships

AI companions are increasingly used for emotional support, companionship, and intimate interaction. While prior work has examined text- and voice-based AI companionship and emerging XR companion designs, less is known about how users with existing close AI companion relationships expect those relationships to change when companions become virtually embodied and spatially situated in everyday environments. To address this gap, we conducted a qualitative study with 17 AI companion users recruited from Reddit AI companion communities. We frame spatially situated virtual embodiment as a form of relational escalation: embodiment can make AI companionship more present, socially legible, and risk-sensitive in everyday life. Our findings show that: (1) embodiment creates tensions between support and intrusion, concreteness and imaginative openness, and growth and consistency; (2) embodiment can turn private AI companionship into a socially legible relational arrangement, requiring visibility, form, interaction style, and mode of access to be negotiated across social contexts; and (3) embodiment can intensify risks of emotional dependence, sensitive disclosure, social judgment, and misguided spatial action by increasing the companion's perceived relational presence, intimacy, public legibility, and spatial authority. We argue that future system design should first consider when embodiment is warranted, how embodied presence should be staged, how visibility and role boundaries should be negotiated, and how embodied companionship can remain safe. This work contributes to HCI research on human-AI intimacy by showing how virtual embodiment can transform close AI companionship into a spatial, socially visible, and risk-sensitive relationship.

cs.HC↗
arXiv2026

Med-V1: Small Language Models for Zero-shot and Scalable Biomedical Evidence Attribution

Assessing whether an article supports an assertion is essential for hallucination detection and claim verification. While large language models (LLMs) have the potential to automate this task, achieving strong performance requires frontier models such as GPT-5 that are prohibitively expensive to deploy at scale. To efficiently perform biomedical evidence attribution, we present Med-V1, a family of small language models with only three billion parameters. Trained on high-quality synthetic data newly developed in this study, Med-V1 substantially outperforms (+27.0% to +71.3%) its base models on five biomedical benchmarks unified into a verification format. Despite its smaller size, Med-V1 performs comparably to frontier LLMs such as GPT-5, along with high-quality explanations for its predictions. We use Med-V1 to conduct a first-of-its-kind use case study that quantifies hallucinations in LLM-generated answers under different citation instructions. Results show that the format instruction strongly affects citation validity and hallucination, with GPT-5 generating more claims but exhibiting hallucination rates similar to GPT-4o. Additionally, we present a second use case showing that Med-V1 can automatically identify high-stakes evidence misattributions in clinical practice guidelines, revealing potentially negative public health impacts that are otherwise challenging to identify at scale. Overall, Med-V1 provides an efficient and accurate lightweight alternative to frontier LLMs for practical and real-world applications in biomedical evidence attribution and verification tasks. Med-V1 is available at https://github.com/ncbi-nlp/Med-V1.

cs.CL↗
arXiv2026

Rethinking Visual Attribution for Chest X-ray Reasoning in Large Vision Language Models

Large Vision Language Models (LVLMs) show promise in medical applications, but their inability to faithfully ground responses in visual evidence raises serious concerns about clinical trustworthiness. While visual attribution methods are widely used to explain LVLM predictions, whether these explanations actually reflect the visual evidence underlying the model's decision is largely unverified, since ground-truth annotations for internal model reasoning are typically unavailable. We address this question for chest X-ray (CXR) reasoning by developing a causal evaluation framework that retains only CXR-VQA samples for which the expert-annotated region is verified, via counterfactual editing, to be causally responsible for the model's prediction. Using this framework across 11 attribution methods, six open-source LVLMs, and two output modes (direct answer and step-by-step reasoning), we find that existing attribution methods often fail to identify the evidence used by LVLMs. To address this failure, we propose MedFocus, a concept-based attribution method that localizes clinically meaningful anatomical regions via unbalanced optimal transport and measures their causal effect on model outputs through targeted interventions. MedFocus produces spatial, concept-level, and token-level attributions and substantially outperforms prior methods, taking a step toward more trustworthy attribution for medical LVLMs. Our data and code are available at https://github.com/gzxiong/medfocus/.

cs.CV↗
arXiv2026

Entry-level guide to the use of large language models for medical research

Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses across diverse contexts and adapting to novel tasks following human instructions. Their potential application spans a broad range of medical tasks, such as clinical documentation, matching patients to clinical trials, and answering medical questions. In this paper, we propose an actionable guideline to help healthcare professionals more effectively and efficiently utilize LLMs in their work, along with a set of best practices. The overall workflow consists of several main phases, including formulating the task, choosing LLMs, prompt engineering, fine-tuning, and model deployment. We start with the discussion of critical considerations in identifying medical tasks that align with the core capabilities of LLMs and selecting models based on the selected task and data, performance requirements, and model interface. We then review the strategies, such as prompt engineering and fine-tuning, to adapt standard LLMs to specialized medical tasks. Deployment considerations, including regulatory compliance, ethical guidelines, and continuous monitoring for fairness and bias, are also discussed. By providing a structured step-by-step methodology, this entry-level tutorial aims to equip healthcare professionals with the tools necessary to effectively integrate LLMs into clinical practice, ensuring that these powerful technologies are applied in a safe, reliable, and impactful manner.

cs.AI↗
arXiv2026

Supervising the search process produces reliable and generalizable information-seeking agents

Large language models (LLMs) are transforming web search by shifting from document ranking to synthesizing answers, and are increasingly deployed as autonomous agentic search systems that iteratively interact with external knowledge sources. Despite this progress, building effective search agents remains challenging because high-quality intermediate search steps are difficult to generate. Previous approaches have primarily relied on outcome supervision, rewarding agents only for producing correct final answers. This often leads to reward hacking and excessive dependence on parametric memory, limiting generalization to out-of-domain tasks. To address these limitations, we introduce RAG-Gym, a framework that shifts supervision from final answers to the search process itself. With RAG-Gym, we systematically investigate architecture design, parameter optimization, and action evaluation, identifying reasoning reflection as a critical capability for search agents. Building on this insight, we propose Re$^2$Search++, a process-supervised agent that achieves substantial improvements on multi-hop information-seeking benchmarks, especially in out-of-domain settings. Performance gains are driven primarily by higher-quality search queries rather than answer optimization alone, and the learned search critics transfer across models, including proprietary LLMs. These findings show that supervising the search process produces more reliable and generalizable information-seeking agents.

cs.CL↗
arXiv2026

Large Language Models Lack Temporal Awareness of Medical Knowledge

The existing methods for evaluating the medical knowledge of Large Language Models (LLMs) are largely based on atemporal examination-style benchmarks, while in reality, medical knowledge is inherently dynamic and continuously evolves as new evidence emerges and treatments are approved. Consequently, evaluating medical knowledge without a temporal context may provide an incomplete assessment of whether LLMs can accurately reason about time-specific medical knowledge. Moreover, most medical data are historical, requiring the models not only to recall the correct knowledge, but also to know when that knowledge is correct. To bridge the gap, we built TempoMed-Bench, the first-of-its-kind benchmark for evaluating the temporal awareness of the LLMs in the medical domain through evolving guideline knowledge. Based on the TempoMed-Bench, our evaluation analysis first reveals that LLMs lack temporal awareness in medical knowledge through the key findings: (1) model performance on up-to-date medical knowledge exhibits a gradual linear decline over time rather than a sharp knowledge-cutoff behavior, suggesting that parametric medical knowledge is not strictly bounded by knowledge cutoffs; (2) LLMs consistently struggle more with recalling outdated historical medical knowledge than with up-to-date recommendations: accuracy of historical knowledge is only 25.37%-53.89% of up-to-date knowledge, indicating potential knowledge forgetting effects during training; and (3) LLMs often exhibit temporally inconsistent behaviors, where predictions fluctuate irregularly across neighboring years. We also show that the temporal awareness problem is a challenge that cannot be easily solved when integrated with agentic search tools (-3.15%-14.14%). This work highlights an important yet underexplored challenge and motivates future research on developing LLMs that can better encode time-specific medical knowledge.

cs.LG↗
arXiv2026

MedHopQA: A Disease-Centered Multi-Hop Reasoning Benchmark and Evaluation Framework for LLM-Based Biomedical Question Answering

Evaluating large language models (LLMs) in the biomedical domain requires benchmarks that can distinguish reasoning from pattern matching and remain discriminative as model capabilities improve. Existing biomedical question answering (QA) benchmarks are limited in this respect. Multiple-choice formats can allow models to succeed through answer elimination rather than inference, while widely circulated exam-style datasets are increasingly vulnerable to performance saturation and training data contamination. Multi-hop reasoning, defined as the ability to integrate information across multiple sources to derive an answer, is central to clinically meaningful tasks such as diagnostic support, literature-based discovery, and hypothesis generation, yet remains underrepresented in current biomedical QA benchmarks. MedHopQA is a disease-centered multi-hop reasoning benchmark consisting of 1,000 expert-curated question-answer pairs introduced as a shared task at BioCreative IX. Each question requires synthesis of information across two distinct Wikipedia articles, and answers are provided in an open-ended free-text format. Gold annotations are augmented with ontology-grounded synonym sets from MONDO, NCBI Gene, and NCBI Taxonomy to support both lexical and concept-level evaluation. MedHopQA was constructed through a structured process combining human annotation, triage, iterative verification, and LLM-as-a-judge validation. To reduce leaderboard gaming and contamination risk, the 1,000 scored questions are embedded within a publicly downloadable set of 10,000 questions, with answers withheld, on a CodaBench leaderboard. MedHopQA provides both a benchmark and a reusable framework for constructing future biomedical QA datasets that prioritize compositional reasoning, saturation resistance, and contamination resistance as core design constraints.

cs.CL↗
arXiv2026

SpatialPrompt: XR-Based Spatial Intent Expression as Executable Constraints for AI Generative 3D Design

We present SpatialPrompt, an Extended Reality(XR) system that turns spatial sketches into executable constraints for controllable 3D generation. Users draw rough structures with a 3D pen and add voice prompts for semantic and stylistic intent. The system supports iterative refinement and synchronous co-creation in shared space with color-coded contributions. Implemented on Apple Vision Pro with Logitech Muse and Meshy, a heuristic evaluation suggests that the workflow is intuitive and supports shared understanding in collaborative creation, while revealing needs for faster generation and clearer feedback.

cs.HC↗
arXiv2026

Designing and Evaluating Next-Generation Learning Interfaces: Linking AI, HCI, and the Learning Sciences

This workshop addresses this gap by bringing together researchers and practitioners from AI, HCI, and the learning sciences to explore how interactive systems can better support learning. We focus on the design and evaluation of human-AI collaborative learning interfaces that are technically robust, human-centered, and pedagogically grounded. By fostering interdisciplinary dialogue, the workshop aims to identify shared challenges, design principles, and research directions for next-generation learning technologies.

cs.HC↗
arXiv2026

SemanticVocoder: Bridging Audio Generation and Audio Understanding via Semantic Latents

Recent audio generation models typically rely on Variational Autoencoders (VAEs) and perform generation within the VAE latent space. Although VAEs excel at compression and reconstruction, their latents inherently encode low-level acoustic details rather than semantically discriminative information, leading to entangled event semantics and complicating the training of generative models. To address these issues, we discard VAE acoustic latents and introduce semantic encoder latents, thereby proposing SemanticVocoder, a generative vocoder that directly synthesizes waveforms from semantic latents. Equipped with SemanticVocoder, our text-to-audio generation model achieves a Frechet Distance of 12.823 and a Frechet Audio Distance of 1.709 on the AudioCaps test set, as the introduced semantic latents exhibit superior discriminability compared to acoustic VAE latents. Beyond improved generation performance, it also serves as a promising attempt towards unifying audio understanding and generation within a shared semantic space. Generated samples are available at https://zeyuxie29.github.io/SemanticVocoder/.

cs.SD↗
arXiv2026

CT-Bench: A Benchmark for Multimodal Lesion Understanding in Computed Tomography

Artificial intelligence (AI) can automatically delineate lesions on computed tomography (CT) and generate radiology report content, yet progress is limited by the scarcity of publicly available CT datasets with lesion-level annotations. To bridge this gap, we introduce CT-Bench, a first-of-its-kind benchmark dataset comprising two components: a Lesion Image and Metadata Set containing 20,335 lesions from 7,795 CT studies with bounding boxes, descriptions, and size information, and a multitask visual question answering benchmark with 2,850 QA pairs covering lesion localization, description, size estimation, and attribute categorization. Hard negative examples are included to reflect real-world diagnostic challenges. We evaluate multiple state-of-the-art multimodal models, including vision-language and medical CLIP variants, by comparing their performance to radiologist assessments, demonstrating the value of CT-Bench as a comprehensive benchmark for lesion analysis. Moreover, fine-tuning models on the Lesion Image and Metadata Set yields significant performance gains across both components, underscoring the clinical utility of CT-Bench.

cs.CV↗
arXiv2026

Benchmarking Retrieval-Augmented Generation for Chemistry

Retrieval-augmented generation (RAG) has emerged as a powerful framework for enhancing large language models (LLMs) with external knowledge, particularly in scientific domains that demand specialized and dynamic information. Despite its promise, the application of RAG in the chemistry domain remains underexplored, primarily due to the lack of high-quality, domain-specific corpora and well-curated evaluation benchmarks. In this work, we introduce ChemRAG-Bench, a comprehensive benchmark designed to systematically assess the effectiveness of RAG across a diverse set of chemistry-related tasks. The accompanying chemistry corpus integrates heterogeneous knowledge sources, including scientific literature, the PubChem database, PubMed abstracts, textbooks, and Wikipedia entries. In addition, we present ChemRAG-Toolkit, a modular and extensible RAG toolkit that supports five retrieval algorithms and eight LLMs. Using ChemRAG-Toolkit, we demonstrate that RAG yields a substantial performance gain -- achieving an average relative improvement of 17.4% over direct inference methods. We further conduct in-depth analyses on retriever architectures, corpus selection, and the number of retrieved passages, culminating in practical recommendations to guide future research and deployment of RAG systems in the chemistry domain. The code and data is available at https://chemrag.github.io.

cs.CL↗
arXiv2026

Sticky Help, Bounded Effects: Session-by-Session Analytics of Teacher Interventions in K-12 Classrooms

Teachers' in-the-moment support is a limited resource in technology-supported classrooms, and teachers must decide whom to help and when during ongoing student work. However, less is known about how students' prior help history (whether they were helped earlier) and their engagement states (e.g., idle, struggle) shape teachers' decisions, and whether observed learning benefits associated with teacher help extend beyond the current class session. To address these questions, we first conducted interviews with nine K-12 mathematics teachers to identify candidate decision factors for teacher help. We then analyzed 1.4 million student-system interactions from 339 students across 14 classes in the MATHia intelligent tutoring system by linking teacher-logged help events with fine-grained engagement states. Mixed-effects models show that students who received help earlier were more likely to receive additional help later, even after accounting for current engagement state. Cross-lagged panel analyses further show that teacher help recurred across sessions, whereas idle behavior did not receive sustained attention over time. Finally, help coincided with immediate learning within sessions, but did not predict skill acquisition in later sessions, as estimated by additive factor modeling. These findings suggest that teacher help is "sticky" in that it recurs for previously supported students, while its measurable learning benefits in our data are largely session-bound. We discuss implications for designing real-time analytics that track attention coverage and highlight under-visited students to support a more equitable and effective allocation of teacher attention.

cs.CY↗
arXiv2026

Secure Text Entry using a Virtual Radial Keyboard with Dynamically Resized Keys and Non-Intrusive Randomization

As virtual reality (VR) becomes more widely adopted, secure and efficient text entry is an increasingly critical need. In this paper, we identify a vulnerability in a state-of-the-art secure VR text entry method and introduce a novel virtual radial keyboard designed to achieve a balance between security with usability. Keys are arranged alphabetically in a circular layout, with each key selected by controller rotation and dynamically expanding to facilitate precise selection. A randomized rotation mechanism shifts the keyboard after each keystroke, preserving relative key positions while disrupting absolute spatial mappings to protect against inference attacks. We conducted a within-subject study (N=30) comparing our method with the prior secure technique and a standard QWERTY keyboard. Results showed that the radial keyboard significantly improves resistance to keystroke prediction attacks while incurring a tradeoff in entry speed and subjective workload due to the unfamiliar non-QWERTY layout. However, both quantitative trends and qualitative feedback indicate strong potential for performance improvements with practice. We also discuss design implications, possible interface refinements, and directions for future work, including layout variations and visual enhancements.

cs.HC↗