arXiv subjects

Qin Ren

Publications and source records attributed to Qin Ren.

10 recordsLinked to original sources

arXiv2026

FreeBridge: Variational Schr\"odinger Bridges for Cellular Transition Dynamics

High-content imaging assays quantify cellular responses to chemical and genetic perturbations, yet continuous trajectories of individual cells are unobservable because cells are chemically fixed at acquisition. Perturbation modeling therefore reduces to inferring stochastic transport between control and treated populations observed only as separate marginals. While recent generative models achieve strong end-point alignment, boundary consistency does not determine intermediate evolution: multiple stochastic processes may connect identical marginals while traversing regions unsupported by observed single-cell morphologies. We introduce \textbf{FreeBridge}, a Schr\"odinger Bridge formulation for single-cell transition modeling under endpoint-only supervision. FreeBridge defines atomic states as instance-segmented single-cell representations, establishing a fixed cellular manifold, and learns stochastic transport constrained within this geometry via empirical latent support regularization. Across BBBC021, RxRx1, and JUMP, FreeBridge maintains competitive or improved endpoint fidelity and mechanism-of-action retention under a unified evaluation protocol; on BBBC021, it further reduces intermediate support violations. These findings highlight the importance of geometric grounding for biologically interpretable perturbation dynamics. Project page: https://y-research-sbu.github.io/FreeBridge/.

cs.LG↗

arXiv2025

Scale Where It Matters: Training-Free Localized Scaling for Diffusion Models

Diffusion models have become the dominant paradigm in text-to-image generation, and test-time scaling (TTS) improves sample quality by allocating additional computation at inference. Existing TTS methods, however, resample the entire image, while generation quality is often spatially heterogeneous. This leads to unnecessary computation on regions that are already correct, and localized defects remain insufficiently corrected. In this paper, we explore a new direction - Localized TTS - that adaptively resamples defective regions while preserving high-quality regions, thereby substantially reducing the search space. This raises two challenges: accurately localizing defects and maintaining global consistency. We propose LoTTS, the first fully training-free framework for localized TTS. For defect localization, LoTTS contrasts cross- and self-attention signals under quality-aware prompts (e.g., high-quality vs. low-quality) to identify defective regions, and then refines them into coherent masks. For consistency, LoTTS perturbs only defective regions and denoises them locally, ensuring that corrections remain confined while the rest of the image remains undisturbed. Extensive experiments on SD2.1, SDXL, and FLUX demonstrate that LoTTS achieves state-of-the-art performance: it consistently improves both local quality and global fidelity, while reducing GPU cost by 2-4x compared to Best-of-N sampling. These findings establish localized TTS as a promising new direction for scaling diffusion models at inference time.

cs.CV↗

arXiv2025

Supervise Less, See More: Training-free Nuclear Instance Segmentation with Prototype-Guided Prompting

Accurate nuclear instance segmentation is a pivotal task in computational pathology, supporting data-driven clinical insights and facilitating downstream translational applications. While large vision foundation models have shown promise for zero-shot biomedical segmentation, most existing approaches still depend on dense supervision and computationally expensive fine-tuning. Consequently, training-free methods present a compelling research direction, yet remain largely unexplored. In this work, we introduce SPROUT, a fully training- and annotation-free prompting framework for nuclear instance segmentation. SPROUT leverages histology-informed priors to construct slide-specific reference prototypes that mitigate domain gaps. These prototypes progressively guide feature alignment through a partial optimal transport scheme. The resulting foreground and background features are transformed into positive and negative point prompts, enabling the Segment Anything Model (SAM) to produce precise nuclear delineations without any parameter updates. Extensive experiments across multiple histopathology benchmarks demonstrate that SPROUT achieves competitive performance without supervision or retraining, establishing a novel paradigm for scalable, training-free nuclear instance segmentation in pathology.

cs.CV↗

arXiv2025

Together, Then Apart: Balancing Alignment and Distinctiveness for Multimodal Survival Analysis

Multimodal survival analysis aims to improve cancer prognosis using heterogeneous biomedical data, such as histopathology images and genomic profiles. A common strategy is to align representations across modalities so that shared signals can be captured. However, strong cross-modal alignment can also remove modality-specific evidence that is critical for survival prediction. In this paper, we revisit multimodal survival learning from a simple observation: effective models should first discover shared patterns across modalities, and then preserve modality-specific signals. This motivates a representation learning principle that we refer to as Together Then Apart. Based on this idea, we propose TTA, a framework that balances cross-modal alignment and representation distinctiveness. TTA first performs prototype-based alignment to capture shared survival-related structures between modalities. It then encourages modality-specific distinctiveness through an anchor-guided contrastive objective. To further account for modality imbalance and noisy correspondences, we model cross-modal interactions using unbalanced optimal transport. We evaluate the proposed approach on multiple TCGA cancer cohorts with paired histopathology and genomic data. TTA consistently improves survival prediction over recent multimodal survival models. Moreover, the learned prototype structures reveal interpretable cross-modal patterns associated with clinical outcomes.

cs.CV↗

arXiv2025

LongRetriever: Towards Ultra-Long Sequence based Candidate Retrieval for Recommendation

Precisely modeling user ultra-long sequences is critical for industrial recommender systems. Current approaches predominantly focus on leveraging ultra-long sequences in the ranking stage, whereas research for the candidate retrieval stage remains under-explored. This paper presents LongRetriever, a practical framework for incorporating ultra-long sequences into the retrieval stage of recommenders. Specifically, we propose in-context training and multi-context retrieval, which enable candidate-specific interaction between user sequence and candidate item, and ensure training-serving consistency under the search-based paradigm. Extensive online A/B testing conducted on a large-scale e-commerce platform demonstrates statistically significant improvements, confirming the framework's effectiveness. Currently, LongRetriever has been fully deployed in the platform, impacting billions of users.

cs.IR↗

arXiv2025

Ouroboros: Single-step Diffusion Models for Cycle-consistent Forward and Inverse Rendering

While multi-step diffusion models have advanced both forward and inverse rendering, existing approaches often treat these problems independently, leading to cycle inconsistency and slow inference speed. In this work, we present Ouroboros, a framework composed of two single-step diffusion models that handle forward and inverse rendering with mutual reinforcement. Our approach extends intrinsic decomposition to both indoor and outdoor scenes and introduces a cycle consistency mechanism that ensures coherence between forward and inverse rendering outputs. Experimental results demonstrate state-of-the-art performance across diverse scenes while achieving substantially faster inference speed compared to other diffusion-based methods. We also demonstrate that Ouroboros can transfer to video decomposition in a training-free manner, reducing temporal inconsistency in video sequences while maintaining high-quality per-frame inverse rendering.

cs.CV↗

arXiv2025

OTSurv: A Novel Multiple Instance Learning Framework for Survival Prediction with Heterogeneity-aware Optimal Transport

Survival prediction using whole slide images (WSIs) can be formulated as a multiple instance learning (MIL) problem. However, existing MIL methods often fail to explicitly capture pathological heterogeneity within WSIs, both globally -- through long-tailed morphological distributions, and locally through -- tile-level prediction uncertainty. Optimal transport (OT) provides a principled way of modeling such heterogeneity by incorporating marginal distribution constraints. Building on this insight, we propose OTSurv, a novel MIL framework from an optimal transport perspective. Specifically, OTSurv formulates survival predictions as a heterogeneity-aware OT problem with two constraints: (1) global long-tail constraint that models prior morphological distributions to avert both mode collapse and excessive uniformity by regulating transport mass allocation, and (2) local uncertainty-aware constraint that prioritizes high-confidence patches while suppressing noise by progressively raising the total transport mass. We then recast the initial OT problem, augmented by these constraints, into an unbalanced OT formulation that can be solved with an efficient, hardware-friendly matrix scaling algorithm. Empirically, OTSurv sets new state-of-the-art results across six popular benchmarks, achieving an absolute 3.6% improvement in average C-index. In addition, OTSurv achieves statistical significance in log-rank tests and offers high interpretability, making it a powerful tool for survival prediction in digital pathology. Our codes are available at https://github.com/Y-Research-SBU/OTSurv.

cs.CV↗

arXiv2025

LONGER: Scaling Up Long Sequence Modeling in Industrial Recommenders

Modeling ultra-long user behavior sequences is critical for capturing both long- and short-term preferences in industrial recommender systems. Existing solutions typically rely on two-stage retrieval or indirect modeling paradigms, incuring upstream-downstream inconsistency and computational inefficiency. In this paper, we present LONGER, a Long-sequence Optimized traNsformer for GPU-Efficient Recommenders. LONGER incorporates (i) a global token mechanism for stabilizing attention over long contexts, (ii) a token merge module with lightweight InnerTransformers and hybrid attention strategy to reduce quadratic complexity, and (iii) a series of engineering optimizations, including training with mixed-precision and activation recomputation, KV cache serving, and the fully synchronous model training and serving framework for unified GPU-based dense and sparse parameter updates. LONGER consistently outperforms strong baselines in both offline metrics and online A/B testing in both advertising and e-commerce services at ByteDance, validating its consistent effectiveness and industrial-level scaling laws. Currently, LONGER has been fully deployed at more than 10 influential scenarios at ByteDance, serving billion users.

cs.IR↗

arXiv2025

Adaptive Domain Scaling for Personalized Sequential Modeling in Recommenders

Users generally exhibit complex behavioral patterns and diverse intentions in multiple business scenarios of super applications like Douyin, presenting great challenges to current industrial multi-domain recommenders. To mitigate the discrepancies across diverse domains, researches and industrial practices generally emphasize sophisticated network structures to accomodate diverse data distributions, while neglecting the inherent understanding of user behavioral sequence from the multi-domain perspective. In this paper, we present Adaptive Domain Scaling (ADS) model, which comprehensively enhances the personalization capability in target-aware sequence modeling across multiple domains. Specifically, ADS comprises of two major modules, including personalized sequence representation generation (PSRG) and personalized candidate representation generation (PCRG). The modules contribute to the tailored multi-domain learning by dynamically learning both the user behavioral sequence item representation and the candidate target item representation under different domains, facilitating adaptive user intention understanding. Experiments are performed on both a public dataset and two billion-scaled industrial datasets, and the extensive results verify the high effectiveness and compatibility of ADS. Besides, we conduct online experiments on two influential business scenarios including Douyin Advertisement Platform and Douyin E-commerce Service Platform, both of which show substantial business improvements. Currently, ADS has been fully deployed in many recommendation services at ByteDance, serving billions of users.

cs.IR↗

arXiv2021

ViBERTgrid: A Jointly Trained Multi-Modal 2D Document Representation for Key Information Extraction from Documents

Recent grid-based document representations like BERTgrid allow the simultaneous encoding of the textual and layout information of a document in a 2D feature map so that state-of-the-art image segmentation and/or object detection models can be straightforwardly leveraged to extract key information from documents. However, such methods have not achieved comparable performance to state-of-the-art sequence- and graph-based methods such as LayoutLM and PICK yet. In this paper, we propose a new multi-modal backbone network by concatenating a BERTgrid to an intermediate layer of a CNN model, where the input of CNN is a document image and the BERTgrid is a grid of word embeddings, to generate a more powerful grid-based document representation, named ViBERTgrid. Unlike BERTgrid, the parameters of BERT and CNN in our multimodal backbone network are trained jointly. Our experimental results demonstrate that this joint training strategy improves significantly the representation ability of ViBERTgrid. Consequently, our ViBERTgrid-based key information extraction approach has achieved state-of-the-art performance on real-world datasets.

cs.CL↗