arXiv subjects

Qindong Zheng

Publications and source records attributed to Qindong Zheng.

3 recordsLinked to original sources

arXiv2026

A Mapping Sheath with Thermally Drawn Multi-Electrode Basket for Cardiac Electrophysiological Recording and Ablation Catheter Delivery

Cardiac arrhythmias, particularly atrial fibrillation, represent a major cardiovascular health burden and underscore the need for efficient and integrated strategies for electrical mapping and targeted therapy. Cardiac electrophysiology procedures depend on accurate identification of arrhythmogenic substrates followed by timely catheter ablation, but conventional diagnostic and therapeutic devices remain separate, often requiring repeated catheter exchanges and multiple access routes. Here, we report an adaptable strategy for functionalizing hollow-core sheaths with EP mapping capabilities, integrating multielectrode recording and ablation catheter delivery within a single compact platform. The device leverages thermal drawing to enable complex geometric fabrication, miniaturization, rapid prototyping, and scalable manufacturing of ultrathin electrode splines arranged circumferentially at the distal end to form an adjustable basket. The mapping sheath exhibited mechanical and electrophysiological properties suitable for intracardiac navigation and electrogram recording in bench-top evaluations, an in vitro left atrial phantom study, and ex vivo Langendorff-perfused porcine heart testing. In vivo porcine studies further demonstrated translational feasibility through vascular introduction, fluoroscopic visualization, intracardiac deployment, tissue contact, electrogram acquisition, and reconstruction of voltage and activation maps. These results support the development of intracardiac platforms with an adapted manufacturing approach, potentially guiding advances in agile cardiac mapping and ablation.

physics.med-ph↗

arXiv2025

Multiplexed Catheter-Integrated Pressure Sensing System for Endoluminal Interventions

Advances in flexible catheters pave the way for minimally invasive diagnosis and treatment of luminal organs and tubular structures through endoluminal interventions. A key challenge is in establishing non-constraining pressure monitoring at the interfaces between medical catheters and intraluminal anatomy exhibiting curvilinear contours, structural variability, and time-dependent physiological motion. This work presents a scalable and multi-purpose pressure sensing system for multidirectional monitoring of tissue interactions, establishing a robust solution for deploying diagnostic and therapeutic instruments in various types of endoluminal interventions. This approach provides an integrated system encompassing pressure sensors, catheters, and signal acquisition devices. A poly (vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) film is miniaturized and configured into a multiplexed piezoelectric-based pressure sensor, providing flexibility and scalability in conforming to medical catheters with curved surfaces. The catheter is fabricated with a cost-effective and highly scalable fiber drawing technology, establishing a means of fast prototyping catheters with bespoke structures for sensor integration and medical instrument integration. The system achieves enhanced pressure detection sensitivity and a comparable sensing range, compared with state-of-the-art catheter-integrated sensors. Through in-vitro phantom studies, the system performs precise multi-directional sensing within various clinical endoluminal scenarios, showing its potential in digitalizing tissue interactions during endoluminal interventions.

physics.med-ph↗

arXiv2024

Precise Hybrid-Actuation Robotic Fiber for Enhanced Cervical Disease Treatment

Treatment for high-grade precancerous cervical lesions and early-stage cancers, mainly affecting women of reproductive age, often involves fertility-sparing treatment methods. Commonly used local treatments for cervical precancers have shown the risk of leaving a positive cancer margin and engendering subsequent complications according to the precision and depth of excision. An intra-operative device that allows the careful excision of the disease while conserving healthy cervical tissue would potentially enhance such treatment. In this study, we developed a polymer-based robotic fiber measuring 150 mm in length and 1.7 mm in diameter, fabricated using a highly scalable fiber drawing technique. This robotic fiber utilizes a hybrid actuation mechanism, combining electrothermal and tendon-driven actuation mechanisms, thus enabling a maximum motion range of 46 mm from its origin with a sub-100 μm motion precision. We also developed control algorithms for the actuation methods of this robotic fiber, including predefined path control and telemanipulation, enabling coarse positioning of the fiber tip to the target area followed by a precise scan. The combination of a surgical laser fiber with the robotic fiber allows for high-precision surgical ablation. Additionally, we conducted experiments using a cervical phantom that demonstrated the robotic fiber's ability to access and perform high-precision scans, highlighting its potential for cervical disease treatments and improvement of oncological outcomes.

cs.RO↗