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Qingguo Xie

Publications and source records attributed to Qingguo Xie.

9 recordsLinked to original sources

Multi-Threshold Sampling: Signal Space, Sampling Operators, and Crossing-Time Distributions

Multi-threshold (MT) sampling records crossing times at selected thresholds for parameter estimation and waveform reconstruction. For suitable high-speed signals, it can reduce data volume, hardware cost, and power consumption compared with high-rate uniform time-domain sampling. Applications in nuclear science include positron emission tomography, oil well logging, and photon-counting X-ray imaging. However, its theoretical foundations require further development to support performance evaluation and system design. A necessary first step is to rigorously define the signal space and sampling operators, but a general mathematical framework for this purpose is still needed. We propose a unified mathematical framework that maps the signal distribution to the distribution of recorded crossings through the sampling operators. It provides a common description of how mismatch and noise in signals and thresholds, time quantization, and selection shape the recorded data, enabling their individual and combined effects to be analyzed. For nonhomogeneous Poisson photon arrivals and deterministic MT sampling, the framework yields the exact distribution of the first recorded crossing time at a specified threshold within a given recorded-time interval. Predictions for a scintillation pulse model agree with independent Monte Carlo simulations, demonstrating the framework's predictive capability. The framework lays the groundwork for determining the fundamental performance limits of MT sampling and designing systems that approach those limits.

eess.SP

A Unified Analytical Framework for LYSO-SiPM Scintillation Pulse Dynamics

Existing scintillation-detector models typically treat scintillation kinetics, optical transport, silicon photomultiplier (SiPM) response, and timing statistics separately, limiting end-to-end prediction of waveform formation and detector performance. We present a unified analytical framework for lutetium-yttrium oxyorthosilicate (LYSO)-SiPM scintillation detectors that links these processes within a single forward model. The framework incorporates finite thermalization, depth-dependent optical transit-time spread, and microcell occupancy dynamics to provide a physics-based description of macroscopic pulse formation. It yields closed-form exponentially modified Gaussian pulses in the linear regime, state-dependent integral solutions in saturation, and recovers the conventional bi-exponential pulse model---ubiquitously used yet hitherto only empirically justified in scintillation pulse fitting and sparse-sampling reconstruction---as a controlled reduction of the full optoelectronic cascade. Experimental validation on 10,000 directly digitized Na-22 pulses shows that the dynamic saturation model captures amplitude-dependent waveform distortion and is favored by the Akaike information criterion (AIC) over a matched bi-exponential baseline in 100/100 high-amplitude pulses and 98/100 medium-amplitude pulses. By coupling the dynamic triggering rate to compound Poisson statistics, the framework also predicts current-variance envelopes and Fisher-information-based timing limits, including an intrinsic coincidence timing resolution lower bound of about 100 ps full width at half maximum (FWHM) for a reference 511-keV LYSO-SiPM configuration. These results deepen the physical understanding of scintillation-detector waveform formation and timing limits by clarifying how scintillation kinetics, optical transport, and SiPM microcell dynamics jointly shape the observed response.

physics.med-ph

Prior-Based Multi-Voltage Threshold Sampling as a Structured Inverse Problem

Prior-based Multi-Voltage Threshold (MVT) sampling reconstructs pulse parameters from sparse threshold-crossing times rather than full waveforms, making parameter recovery inherently a model-dependent inverse problem. However, prior-based MVT has lacked a formal mathematical statement, leaving identifiability, stochastic error propagation, and threshold design without a unified theoretical foundation. We formalize prior-based MVT for strictly unimodal pulse families as a structured inverse problem. On that foundation, we develop the first unified theory of prior-based MVT, comprising deterministic identifiability conditions, a stochastic timing-error model with leading-order mismatch bias, and a nuisance-profiled threshold-design theory centered on an effective-information equation for robust single-event and partial-trigger multi-event operation. We instantiate the framework for the bi-exponential pulse model, derive executable design recipes, and validate the resulting predictions on a 10,000-pulse $^{22}$Na/LYSO/SiPM dataset. The experiments confirm that the framework yields useful threshold designs in the photopeak regime while also revealing the regime boundary at which partial triggering and model mismatch limit the predictive power of Fisher-guided optimization. These results provide the first unified mathematical foundation for prior-based MVT and recast it from an empirical threshold heuristic as a principled inferential framework.

physics.med-ph

Super-resolution positron emission tomography by intensity modulation: Proof of concept

We proposed a new approach, which is inspired by the method of super-resolution (SR) structured illumination microscopy (SIM) for overcoming the resolution limit in microscopy due to diffraction of light, for increasing the resolution of clinical positron emission tomography (PET) beyond its instrumentation limit. We implemented the key idea behind SR-SIM by using a rotating intensity modulator in front of a stationary PET detector ring. Its function is to modulate down high-frequency signals of the projection data that originally were above the system's bandwidth and unobservable to appear as aliased lower-frequency ones that are detectable. We formulated a model that relates an image whose resolution is above the instrumentation limit to several thus obtained limited-resolution measurements at various rotational positions of the modulator. We implemented an ordered-subsets expectation-maximization algorithm for inverting the model. Using noise-free data produced by an analytic projector, we showed this approach can resolve 0.9 mm sources when applied to a PET system that employs 4.2 mm-width detectors. With noisy data, the SR performance remains promising. In particular, 1.5 mm sources were resolvable, and the visibility and quantification of small sources and fine structures were improved despite the sensitivity loss incurred by the modulator. These observations remain valid when using more realistic Monte-Carlo simulation data. More studies are needed to better understand the theoretical aspects of the proposed method and to optimize the design of the modulator and the reconstruction algorithm.

physics.med-ph

Analytic Model of Trans-axial Sensitivity in Cylindrical PET Systems Based on Solid Angle

In positron emission tomography (PET), a clear theoretical model describing how system sensitivity varies as a source is moved trans-axially within the field of view (FOV) is lacking. The current understanding and practical intuition often suggest that sensitivity is maximum at the center of the FOV, an assumption reflected in standardized protocols. In this work, we derive an analytic model for the trans-axial-plane sensitivity distribution in a cylindrical PET scanner based on solid angle. The model, formulated as a function of trans-axial offset from the center, is validated through both Monte Carlo simulations and physical experiments on a representative system. We find that the derived theoretical distribution is essentially consistent with simulation and experimental results, revealing a non-intuitive feature: sensitivity increases with trans-axial offset, peaks at the edge of the FOV, and drops off sharply beyond it. This study provides the first closed-form model of trans-axial geometric sensitivity in cylindrical PET scanners, offering a vital benchmark for isolating detector technology improvements and revealing a non-intuitive, offset-dependent sensitivity profile that enables new protocol optimization strategies.

physics.med-ph

Development and experimental validation of an in-house treatment planning system with greedy energy layer optimization for fast IMPT

Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to tumor targets and spare nearby organs-at-risk (OAR). Fast delivery of IMPT can improve patient comfort and reduce motion-induced uncertainties. Since energy layer switching time dominants the plan delivery time, reducing the number of energy layers is important for improving delivery efficiency. Although various energy layer optimization (ELO) methods exist, they are rarely experimentally validated or clinically implemented, since it is technically challenging to integrate these methods into commercially available treatment planning system (TPS) that is not open-source. Methods: The dose calculation accuracy of IH-TPS is verified against the measured beam data and the RayStation TPS. For treatment planning, a novel ELO method via greed selection algorithm is proposed to reduce energy layer switching time and total plan delivery time. To validate the planning accuracy of IH-TPS, the 3D gamma index is calculated between IH-TPS plans and RayStation plans for various scenarios. Patient-specific quality-assurance (QA) verifications are conducted to experimentally verify the delivered dose from the IH-TPS plans for several clinical cases. Results: Dose distributions in IH-TPS matched with those from RayStation TPS, with 3D gamma index results exceeding 95% (2mm, 2%). The ELO method significantly reduced the delivery time while maintaining plan quality. For instance, in a brain case, the number of energy layers was reduced from 78 to 40, leading to a 62% reduction in total delivery time. Patient-specific QA validation with the IBA Proteus ONE proton machine confirmed a >95% pass rate for all cases.

physics.med-ph

Potential Advantages of Peak Picking Multi-Voltage Threshold Digitizer in Energy Determination in Radiation Measurement

The Multi-voltage Threshold (MVT) method, which samples the signal by certain reference voltages, has been well developed as being adopted in pre-clinical and clinical digital positron emission tomography(PET) system. To improve its energy measurement performance, we propose a Peak Picking MVT(PP-MVT) Digitizer in this paper. Firstly, a sampled Peak Point(the highest point in pulse signal), which carries the values of amplitude feature voltage and amplitude arriving time, is added to traditional MVT with a simple peak sampling circuit. Secondly, an amplitude deviation statistical analysis, which compares the energy deviation of various reconstruction models, is used to select adaptive reconstruction models for signal pulses with different amplitudes. After processing 30,000 randomly-chosen pulses sampled by the oscilloscope with a 22Na point source, our method achieves an energy resolution of 17.50% within a 450-650 KeV energy window, which is 2.44% better than the result of traditional MVT with same thresholds; and we get a count number at 15225 in the same energy window while the result of MVT is at 14678. When the PP-MVT involves less thresholds than traditional MVT, the advantages of better energy resolution and larger count number can still be maintained, which shows the robustness and the flexibility of PP-MVT Digitizer. This improved method indicates that adding feature peak information could improve the performance on signal sampling and reconstruction, which canbe proved by the better performance in energy determination in radiation measurement.

eess.SP

Development of a PET/EPRI combined imaging system for assessing tumor hypoxia

Precise quantitative delineation of tumor hypoxia is essential in radiation therapy treatment planning to improve the treatment efficacy by targeting hypoxic sub-volumes. We developed a combined imaging system of positron emission tomography (PET) and electron para-magnetic resonance imaging (EPRI) of molecular oxygen to investigate the accuracy of PET imaging in assessing tumor hypoxia. The PET/EPRI combined imaging system aims to use EPRI to precisely measure the oxygen partial pressure in tissues. This will evaluate the validity of PET hypoxic tumor imaging by (near) simultaneously acquired EPRI as ground truth. The combined imaging system was constructed by integrating a small animal PET scanner (inner ring diameter 62 mm and axial field of view 25.6 mm) and an EPRI subsystem (field strength 25 mT and resonant frequency 700 MHz). The compatibility between the PET and EPRI subsystems were tested with both phantom and animal imaging. Hypoxic imaging on a tumor mouse model using $^{18}$F-fluoromisonidazole radio-tracer was conducted with the developed PET/EPRI system. We report the development and initial imaging results obtained from the PET/EPRI combined imaging system.

physics.med-ph

Segmentation-Free X-ray Energy Spectrum Estimation for Computed Tomography Using Dual-Energy Material Decomposition

X-ray energy spectrum plays an essential role in computed tomography (CT) imaging and related tasks. Due to the high photon flux of clinical CT scanners, most of spectrum estimation methods are indirect and usually suffered from various limitations. In this study, we aim to provide a segmentation-free indirect transmission measurement-based energy spectrum estimation method using dual-energy material decomposition. The general principle of the method is to minimize the quadratic error between the polychromatic forward projection and the raw projection to calibrate a set of unknown weights which are used to express the unknown spectrum together with a set of model spectra. The polychromatic forward projection is performed using material-specific images which are obtained using dual-energy material decomposition. The algorithm has been evaluated using numerical simulations, experimental phantom data as well as realistic patient data. The results show the estimated spectrum matches the reference spectrum quite well and the method is robust. Extensive studies suggest the method provides accurate estimate of the CT spectrum without dedicated physical phantom and prolonged work flow. This paper may be attractive for CT dose calculations, artifacts reduction, polychromatic image reconstruction and other spectrum-involved CT applications.

physics.med-ph