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Qiong Xiao

Publications and source records attributed to Qiong Xiao.

7 recordsLinked to original sources
arXiv2026

A Synthetic Data-Driven Radiology Foundation Model for Pan-tumor Clinical Diagnosis

AI-assisted imaging made substantial advances in tumor diagnosis and management. However, a major barrier to developing robust oncology foundation models is the scarcity of large-scale, high-quality annotated datasets, which are limited by privacy restrictions and the high cost of manual labeling. To address this gap, we present PASTA, a pan-tumor radiology foundation model built on PASTA-Gen, a synthetic data framework that generated 30,000 3D CT scans with pixel-level lesion masks and structured reports of tumors across ten organ systems. Leveraging this resource, PASTA achieves state-of-the-art performance on 45 of 46 oncology tasks, including non-contrast CT tumor screening, lesion segmentation, structured reporting, tumor staging, survival prediction, and MRI-modality transfer. To assess clinical applicability, we developed PASTA-AID, a clinical decision support system, and ran a retrospective simulated clinical trial across two scenarios. For pan-tumor screening on plain CT with fixed reading time, PASTA-AID increased radiologists' throughput by 11.1-25.1% and improved sensitivity by 17.0-31.4% and precision by 10.5-24.9%; additionally, in a diagnosis-aid workflow, it reduced segmentation time by up to 78.2% and reporting time by up to 36.5%. Beyond gains in accuracy and efficiency, PASTA-AID narrowed the expertise gap, enabling less-experienced radiologists to approach expert-level performance. Together, this work establishes an end-to-end, synthetic data-driven pipeline spanning data generation, model development, and clinical validation, thereby demonstrating substantial potential for pan-tumor research and clinical translation.

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arXiv2026

CT Synthesis with Conditional Diffusion Models for Abdominal Lymph Node Segmentation

Despite the significant success achieved by deep learning methods in medical image segmentation, researchers still struggle in the computer-aided diagnosis of abdominal lymph nodes due to the complex abdominal environment, small and indistinguishable lesions, and limited annotated data. To address these problems, we present a pipeline that integrates the conditional diffusion model for lymph node generation and the nnU-Net model for lymph node segmentation to improve the segmentation performance of abdominal lymph nodes through synthesizing a diversity of realistic abdominal lymph node data. We propose LN-DDPM, a conditional denoising diffusion probabilistic model (DDPM) for lymph node (LN) generation. LN-DDPM utilizes lymph node masks and anatomical structure masks as model conditions. These conditions work in two conditioning mechanisms: global structure conditioning and local detail conditioning, to distinguish between lymph nodes and their surroundings and better capture lymph node characteristics. The obtained paired abdominal lymph node images and masks are used for the downstream segmentation task. Experimental results on the abdominal lymph node datasets demonstrate that LN-DDPM outperforms other generative methods in the abdominal lymph node image synthesis and better assists the downstream abdominal lymph node segmentation task.

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arXiv2025

Charge state regulation of nuclear excitation by electron capture in $^{229}$Th ions

Nuclear excitation by electron capture (NEEC) in $^{229}$Th holds significant potential for precise nuclear state manipulation. In this study, we thoroughly investigate NEEC in $^{229}\text{Th}^{q+}$ ions by integrating quantum numbers ($n, l, j$) effects and analyzing key parameters (e.g., resonance energy $E_r$, cross section $σ$, resonance strength $S$, and NEEC transition width $Γ_{\text{NEEC}}$) influences across charge state from $q=1^+$ to $90^+$. Especially, we focus on the charge-state regulation of the isomeric state (IS, 8.36 eV) and second-excited state (SE, 29.19 keV). Our calculations uncover critical charge-state-dependent behaviors of NEEC in $^{229}\text{Th}$ ions: (1) For the IS, valid NEEC channels exhibit threshold migration, where the dominant principal quantum number $n$ increases linearly with $q$ following the relation $n \approx 1.28q + 4.23$; meanwhile, single-$n$-channel $S$ stabilizes between $10^{-2}$ to $10^0$ barn eV via compensatory nucleus-electron coupling, ensuring the total resonance $S$ constant. (2) For the SE, its excitation energy far exceeds nearly all electron binding energies, leading to negligible channel screening and causing the total $S$ to increase monotonically with $q$. This research clarifies the intrinsic mechanisms of charge-state-driven nuclear-electronic interactions in $^{229}\text{Th}^{q+}$ NEEC and provides a critical reference for future experimental efforts to manipulate $^{229}\text{Th}$ nuclear states, particularly via indirect regulation of the SE.

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arXiv2025

Cascading nuclear excitation of \(^{235}\text{U}\) via inelastic electron scattering in laser-irradiated clusters

Nuclear excitation induced by lasers holds broad application prospects in precision metrology and nuclear energy, such as nuclear batteries and nuclear clocks. In the present work, the nuclear excitation via inelastic electron scattering (NEIES) mechanism in \(^{235}\text{U}\) is investigated by combining the Dirac-Hartree-Fock-Slater method for theoretical calculations with 2D3V particle-in-cell (PIC) simulations for numerical modeling. The excitation cross-sections of \(^{235}\text{U}\) from the ground state to excited states is evaluated and an efficient indirect excitation scheme for generating \(^{235}\text{U}\) isomers is proposed by first exciting the nuclei from ground-state to high-energy excited states and then decays to the isomeric state. The calculations show that laser-tuned multi-channel NEIES can boost isomeric state accumulation efficiency by eleven orders of magnitude over direct excitation. Additionally, PIC simulations reveal that laser polarization significantly alters high-energy electron distributions. At identical intensity, p-polarized lasers generate seven times more electrons with energies sufficient for exciting $^{235}\text{U}$ to the second excited state (and beyond to the fourth state) compared to s-polarization. This work offers a practical and feasible way for efficient isomeric state generation, supporting experimental tests of laser-driven nuclear excitation in sub-TW lasers.

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arXiv2024

Inelastic electron scattering-induced nuclear excitation rates and dynamics in $^{229}$Th

In the present work, we investigate the excitation rates and population dynamics of $^{229}$Th nuclei induced by inelastic electron scattering, focusing on how electron energy, flux, and ionic charge state influence the excitation process of the nuclei. Using the Dirac Hartree-Fock-Slater method, we calculate cross sections for both the isomeric state (8.36 eV) and the second-excited state (29.19 keV) of $^{229}$Th over a wide range of ionic charge states and electron energies. Our results demonstrate that these factors significantly impact the nuclear excitation efficiency. The effect of indirect excitation through the second-excited state on enhancing the accumulation of nuclei in the isomeric state cannot be ignored. By applying rate equations to model the temporal evolution of nuclear populations, we show that under optimal conditions, up to 10\% of $^{229}$Th$^{4+}$ ions can be accumulated in the isomeric state. These findings provide important insights for optimizing electron-nucleus interactions, contributing to the development of $^{229}$Th-based nuclear clocks and relevant precision measurement applications.

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arXiv2023

Laser-assisted deformed $α$ decay of the ground state even-even nuclei

In the present work, the influence of ultra-intense laser fields on the $α$ decay half-life of the deformed ground state even-even nucleus with the mass number $52 \leq Z \leq 118$ is systematically studied. The calculations show that the laser field changes the $α$ decay half-life by varying the $α$ decay penetration probability in a small range. Moreover, the analytical formulas for the rate of change of the $α$ decay penetration probability in the ultra-intense laser fields have been derived by the spherical approximation, which agrees well with the numerical solutions for nuclei with more significant proton numbers. This provides a fast way to estimate the rate of change of the $α$ decay penetration probability for superheavy nuclei. Furthermore, the relationship between laser properties and the average rate of change of the $α$ decay penetration probability is investigated. The calculations indicate that the shorter the wavelength of the laser pulse is, the larger the average rate of change of the penetration probability.

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arXiv2022

Half-lives for proton emission and α decay within the deformed Gamow-like model

In the present work, we study α decay and proton emission half-lives within the modified Gamow-like model, which introduces the effects of the nucleus's deformation. The calculations show that it is necessary to consider the deformation in the calculation for nuclei far from the shell. Moreover, we use the improved model to predict the proton emission half-lives of the nuclei far from the shell. The calculation results indicate that our model is in good agreement with most models. Furthermore, the deformed Gamow-like model is used to find the following neutron magic number. This work is meaningful for future research on superheavy nuclei.

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