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R. Dubois

Publications and source records attributed to R. Dubois.

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Critical fluctuations of the electrical activity of the heart: Shortcomings of models of excitability and interpretation

We report unexpected evidence of critical fluctuations of the electric potential of the heart during atrial fibrillation in humans. Scale invariance and long range correlations are found, which we show cannot be accounted for solely with the property of excitability, since disorder emerges by the formation of chaotic patterns in excitable media. To shed light on the data, we discuss the hypothesis that, in fact, fibrillation appears through a phase transition, which we compare on phenomenological grounds to a quenched-in disorder magnetic transition. We infer that, during propagation of pulses, random pinning might occur due to random modulation of the gap junction channels.

q-bio.TO

Towards the selection of patients requiring ICD implantation by automatic classification from Holter monitoring indices

The purpose of this study is to optimize the selection of prophylactic cardioverter defibrillator implantation candidates. Currently, the main criterion for implantation is a low Left Ventricular Ejection Fraction (LVEF) whose specificity is relatively poor. We designed two classifiers aimed to predict, from long term ECG recordings (Holter), whether a low-LVEF patient is likely or not to undergo ventricular arrhythmia in the next six months. One classifier is a single hidden layer neural network whose variables are the most relevant features extracted from Holter recordings, and the other classifier has a structure that capitalizes on the physiological decomposition of the arrhythmogenic factors into three disjoint groups: the myocardial substrate, the triggers and the autonomic nervous system (ANS). In this ad hoc network, the features were assigned to each group; one neural network classifier per group was designed and its complexity was optimized. The outputs of the classifiers were fed to a single neuron that provided the required probability estimate. The latter was thresholded for final discrimination A dataset composed of 186 pre-implantation 30-mn Holter recordings of patients equipped with an implantable cardioverter defibrillator (ICD) in primary prevention was used in order to design and test this classifier. 44 out of 186 patients underwent at least one treated ventricular arrhythmia during the six-month follow-up period. Performances of the designed classifier were evaluated using a cross-test strategy that consists in splitting the database into several combinations of a training set and a test set. The average arrhythmia prediction performances of the ad-hoc classifier are NPV = 77% $\pm$ 13% and PPV = 31% $\pm$ 19% (Negative Predictive Value $\pm$ std, Positive Predictive Value $\pm$ std). According to our study, improving prophylactic ICD-implantation candidate selection by automatic classification from ECG features may be possible, but the availability of a sizable dataset appears to be essential to decrease the number of False Negatives.

cs.LG

The missing GeV γ-ray binary: Searching for HESS J0632+057 with Fermi-LAT

The very high energy (VHE; >100 GeV) source HESS J0632+057 has been recently confirmed as a γ-ray binary, a subclass of the high mass X-ray binary (HMXB) population, through the detection of an orbital period of 321 days. We performed a deep search for the emission of HESS J0632+057 in the GeV energy range using data from the Fermi Large Area Telescope (LAT). The analysis was challenging due to the source being located in close proximity to the bright γ-ray pulsar PSR J0633+0632 and lying in a crowded region of the Galactic plane where there is prominent diffuse emission. We formulated a Bayesian block algorithm adapted to work with weighted photon counts, in order to define the off-pulse phases of PSR J0633+0632. A detailed spectral-spatial model of a 5 deg circular region centred on the known location of HESS J0632+057 was generated to accurately model the LAT data. No significant emission from the location of HESS J0632+057 was detected in the 0.1-100 GeV energy range integrating over ~3.5 years of data; with a 95% flux upper limit of F_{0.1-100 GeV} < 3 x 10-8 ph cm-2 s-1. A search for emission over different phases of the orbit also yielded no significant detection. A search for source emission on shorter timescales (days--months) did not yield any significant detections. We also report the results of a search for radio pulsations using the 100-m Green Bank Telescope (GBT). No periodic signals or individual dispersed bursts of a likely astronomical origin were detected. We estimated the flux density limit of < 90/40 μJy at 2/9 GHz. The LAT flux upper limits combined with the detection of HESS J0632+057 in the 136-400 TeV energy band by the MAGIC collaboration imply that the VHE spectrum must turn over at energies <136 GeV placing constraints on any theoretical models invoked to explain the γ-ray emission.

astro-ph.HE

Binary Millisecond Pulsar Discovery via Gamma-Ray Pulsations

Millisecond pulsars, old neutron stars spun-up by accreting matter from a companion star, can reach high rotation rates of hundreds of revolutions per second. Until now, all such "recycled" rotation-powered pulsars have been detected by their spin-modulated radio emission. In a computing-intensive blind search of gamma-ray data from the Fermi Large Area Telescope (with partial constraints from optical data), we detected a 2.5-millisecond pulsar, PSR J1311-3430. This unambiguously explains a formerly unidentified gamma-ray source that had been a decade-long enigma, confirming previous conjectures. The pulsar is in a circular orbit with an orbital period of only 93 minutes, the shortest of any spin-powered pulsar binary ever found.

astro-ph.HE

Multi-wavelength observations of blazar AO 0235+164 in the 2008-2009 flaring state

The blazar AO 0235+164 (z = 0.94) has been one of the most active objects observed by Fermi Large Area Telescope (LAT) since its launch in Summer 2008. In addition to the continuous coverage by Fermi, contemporaneous observations were carried out from the radio to γ -ray bands between 2008 September and 2009 February. In this paper, we summarize the rich multi-wavelength data collected during the campaign (including F-GAMMA, GASP- WEBT, Kanata, OVRO, RXTE, SMARTS, Swift, and other instruments), examine the cross-correlation between the light curves measured in the different energy bands, and interpret the resulting spectral energy distributions in the context of well-known blazar emission models. We find that the γ -ray activity is well correlated with a series of near-IR/optical flares, accompanied by an increase in the optical polarization degree. On the other hand, the X-ray light curve shows a distinct 20 day high state of unusually soft spectrum, which does not match the extrapolation of the optical/UV synchrotron spectrum. We tentatively interpret this feature as the bulk Compton emission by cold electrons contained in the jet, which requires an accretion disk corona with an effective covering factor of 19% at a distance of 100 Rg . We model the broadband spectra with a leptonic model with external radiation dominated by the infrared emission from the dusty torus.

astro-ph.HE

Anisotropies in the diffuse gamma-ray background measured by the Fermi LAT

The contribution of unresolved sources to the diffuse gamma-ray background could induce anisotropies in this emission on small angular scales. We analyze the angular power spectrum of the diffuse emission measured by the Fermi LAT at Galactic latitudes |b| > 30 deg in four energy bins spanning 1 to 50 GeV. At multipoles \ell \ge 155, corresponding to angular scales \lesssim 2 deg, angular power above the photon noise level is detected at >99.99% CL in the 1-2 GeV, 2-5 GeV, and 5-10 GeV energy bins, and at >99% CL at 10-50 GeV. Within each energy bin the measured angular power takes approximately the same value at all multipoles \ell \ge 155, suggesting that it originates from the contribution of one or more unclustered source populations. The amplitude of the angular power normalized to the mean intensity in each energy bin is consistent with a constant value at all energies, C_P/ ^2 = 9.05 +/- 0.84 x 10^{-6} sr, while the energy dependence of C_P is consistent with the anisotropy arising from one or more source populations with power-law photon spectra with spectral index Γ_s = 2.40 +/- 0.07. We discuss the implications of the measured angular power for gamma-ray source populations that may provide a contribution to the diffuse gamma-ray background.

astro-ph.HE

Long-term monitoring of the high-energy gamma-ray emission from LS I +61° 303 and LS 5039

The Fermi Large Area Telescope (LAT) reported the first definitive GeV detections of the binaries LS I +61\degree 303 and LS 5039 in the first year after its launch in June, 2008. These detections were unambiguous as a consequence of the reduced positional uncertainty and the detection of modulated gamma-ray emission on the corresponding orbital periods. An analysis of new data from the LAT, comprising 30 months of observations, identifies a change in the gamma-ray behavior of LS I +61\degree 303. An increase in flux is detected in March 2009 and a steady decline in the orbital flux modulation is observed. Significant emission up to 30GeV is detected by the LAT; prior datasets led to upper limits only. Contemporaneous TeV observations no longer detected the source, or found it -in one orbit- close to periastron, far from the phases at which the source previously appeared at TeV energies. The detailed numerical simulations and models that exist within the literature do not predict or explain many of these features now observed at GeV and TeV energies. New ideas and models are needed to fully explain and understand this behavior. A detailed phase-resolved analysis of the spectral characterization of LS I +61\degree 303 in the GeV regime ascribes a power law with an exponential cutoff spectrum along each analyzed portion of the system's orbit. The on-source exposure of LS 5039 is also substantially increased with respect to our prior publication. In this case, whereas the general gamma-ray properties remain consistent, the increased statistics of the current dataset allows for a deeper investigation of its orbital and spectral evolution.

astro-ph.HE

A giant radio flare from Cygnus X-3 with associated Gamma-ray emission

With frequent flaring activity of its relativistic jets, Cygnus X-3 is one of the most active microquasars and is the only Galactic black hole candidate with confirmed high energy Gamma-ray emission, thanks to detections by Fermi/LAT and AGILE. In 2011, Cygnus X-3 was observed to transit to a soft X-ray state, which is known to be associated with high-energy Gamma-ray emission. We present the results of a multi-wavelength campaign covering a quenched state, when radio emission from Cygnus X-3 is at its weakest and the X-ray spectrum is very soft. A giant (~ 20 Jy) optically thin radio flare marks the end of the quenched state, accompanied by rising non-thermal hard X-rays. Fermi/LAT observations (E >100 MeV) reveal renewed Gamma-ray activity associated with this giant radio flare, suggesting a common origin for all non-thermal components. In addition, current observations unambiguously show that the Gamma-ray emission is not exclusively related to the rare giant radio flares. A 3-week period of Gamma-ray emission is also detected when Cygnus X-3 was weakly flaring in radio, right before transition to the radio quenched state. No Gamma rays are observed during the ~ one-month long quenched state, when the radio flux is weakest. Our results suggest transitions into and out of the ultrasoft X-ray (radio quenched) state trigger Gamma-ray emission, implying a connection to the accretion process, and also that the Gamma-ray activity is related to the level of radio flux (and possibly shock formation), strengthening the connection to the relativistic jets.

astro-ph.HE

The radio/gamma-ray connection in Active Galactic Nuclei in the era of the Fermi Large Area Telescope

We present a detailed statistical analysis of the correlation between radio and gamma-ray emission of the Active Galactic Nuclei (AGN) detected by Fermi during its first year of operation, with the largest datasets ever used for this purpose. We use both archival interferometric 8.4 GHz data (from the VLA and ATCA, for the full sample of 599 sources) and concurrent single-dish 15 GHz measurements from the Owens Valley Radio Observatory (OVRO, for a sub sample of 199 objects). Our unprecedentedly large sample permits us to assess with high accuracy the statistical significance of the correlation, using a surrogate-data method designed to simultaneously account for common-distance bias and the effect of a limited dynamical range in the observed quantities. We find that the statistical significance of a positive correlation between the cm radio and the broad band (E>100 MeV) gamma-ray energy flux is very high for the whole AGN sample, with a probability <1e-7 for the correlation appearing by chance. Using the OVRO data, we find that concurrent data improve the significance of the correlation from 1.6e-6 to 9.0e-8. Our large sample size allows us to study the dependence of correlation strength and significance on specific source types and gamma-ray energy band. We find that the correlation is very significant (chance probability <1e-7) for both FSRQs and BL Lacs separately; a dependence of the correlation strength on the considered gamma-ray energy band is also present, but additional data will be necessary to constrain its significance.

astro-ph.CO

The bright unidentified gamma-ray source 1FGL J1227.9-4852: Can it be associated with an LMXB?

We present an analysis of high energy (HE; 0.1-300 GeV) gamma-ray observations of 1FGL J1227.9-4852 with the Fermi Gamma-ray Space Telescope, follow-up radio observations with the Australia Telescope Compact Array, Giant Metrewave Radio Telescope and Parkes radio telescopes of the same field and follow-up optical observations with the ESO VLT. We also examine archival XMM-Newton and INTEGRAL X-ray observations of the region around this source. The gamma-ray spectrum of 1FGL J1227.9-4852 is best fit with an exponentially cutoff power-law, reminiscent of the population of pulsars observed by Fermi. A previously unknown, compact radio source within the 99.7% error circle of 1FGL J1227.9-4852 is discovered and has a morphology consistent either with an AGN core/jet structure or with two roughly symmetric lobes of a distant radio galaxy. A single bright X-ray source XSS J12270-4859, a low-mass X-ray binary, also lies within the 1FGL J1227.9-4852 error circle and we report the first detection of radio emission from this source. The potential association of 1FGL J1227.9-4852 with each of these counterparts is discussed. Based upon the available data we find the association of the gamma-ray source to the compact double radio source unlikely and suggest that XSS J12270-4859 is a more likely counterpart to the new HE source. We propose that XSS J12270-4859 may be a millisecond binary pulsar and draw comparisons with PSR J1023+0038.

astro-ph.HE

Constraints on Cosmological Dark Matter Annihilation from the Fermi-LAT Isotropic Diffuse Gamma-Ray Measurement

The first published Fermi large area telescope (Fermi-LAT) measurement of the isotropic diffuse gamma-ray emission is in good agreement with a single power law, and is not showing any signature of a dominant contribution from dark matter sources in the energy range from 20 to 100 GeV. We use the absolute size and spectral shape of this measured flux to derive cross section limits on three types of generic dark matter candidates: annihilating into quarks, charged leptons and monochromatic photons. Predicted gamma-ray fluxes from annihilating dark matter are strongly affected by the underlying distribution of dark matter, and by using different available results of matter structure formation we assess these uncertainties. We also quantify how the dark matter constraints depend on the assumed conventional backgrounds and on the Universe's transparency to high-energy gamma-rays. In reasonable background and dark matter structure scenarios (but not in all scenarios we consider) it is possible to exclude models proposed to explain the excess of electrons and positrons measured by the Fermi-LAT and PAMELA experiments. Derived limits also start to probe cross sections expected from thermally produced relics (e.g. in minimal supersymmetry models) annihilating predominantly into quarks. For the monochromatic gamma-ray signature, the current measurement constrains only dark matter scenarios with very strong signals.

astro-ph.CO

Fermi LAT Search for Photon Lines from 30 to 200 GeV and Dark Matter Implications

Dark matter (DM) particle annihilation or decay can produce monochromatic $γ$-rays readily distinguishable from astrophysical sources. $γ$-ray line limits from 30 GeV to 200 GeV obtained from 11 months of Fermi Large Area Space Telescope data from 20-300 GeV are presented using a selection based on requirements for a $γ$-ray line analysis, and integrated over most of the sky. We obtain $γ$-ray line flux upper limits in the range $0.6-4.5\times 10^{-9}\mathrm{cm}^{-2}\mathrm{s}^{-1}$, and give corresponding DM annihilation cross-section and decay lifetime limits. Theoretical implications are briefly discussed.

astro-ph.HE

Observations of Milky Way Dwarf Spheroidal galaxies with the Fermi-LAT detector and constraints on Dark Matter models

We report on the observations of 14 dwarf spheroidal galaxies with the Fermi Gamma-Ray Space Telescope taken during the first 11 months of survey mode operations. The Fermi telescope provides a new opportunity to test particle dark matter models through the expected gamma-ray emission produced by pair annihilation of weakly interacting massive particles (WIMPs). Local Group dwarf spheroidal galaxies, the largest galactic substructures predicted by the cold dark matter scenario, are attractive targets for such indirect searches for dark matter because they are nearby and among the most extreme dark matter dominated environments. No significant gamma-ray emission was detected above 100 MeV from the candidate dwarf galaxies. We determine upper limits to the gamma-ray flux assuming both power-law spectra and representative spectra from WIMP annihilation. The resulting integral flux above 100 MeV is constrained to be at a level below around 10^-9 photons cm^-2 s^-1. Using recent stellar kinematic data, the gamma-ray flux limits are combined with improved determinations of the dark matter density profile in 8 of the 14 candidate dwarfs to place limits on the pair annihilation cross-section of WIMPs in several widely studied extensions of the standard model. With the present data, we are able to rule out large parts of the parameter space where the thermal relic density is below the observed cosmological dark matter density and WIMPs (neutralinos here) are dominantly produced non-thermally, e.g. in models where supersymmetry breaking occurs via anomaly mediation. The gamma-ray limits presented here also constrain some WIMP models proposed to explain the Fermi and PAMELA e^+e^- data, including low-mass wino-like neutralinos and models with TeV masses pair-annihilating into muon-antimuon pairs. (Abridged)

astro-ph.CO

The Spectral Energy Distribution of Fermi bright blazars

(Abridged) We have conducted a detailed investigation of the broad-band spectral properties of the γ-ray selected blazars of the Fermi LAT Bright AGN Sample (LBAS). By combining our accurately estimated Fermi gamma-ray spectra with Swift, radio, infra-red, optical and other hard X-ray/gamma-ray data, collected within three months of the LBAS data taking period, we were able to assemble high-quality and quasi-simultaneous Spectral Energy Distributions (SED) for 48 LBAS blazars.The SED of these gamma-ray sources is similar to that of blazars discovered at other wavelengths, clearly showing, in the usual Log $ν$ - Log $ν$ F$_ν$ representation, the typical broad-band spectral signatures normally attributed to a combination of low-energy synchrotron radiation followed by inverse Compton emission of one or more components. We have used these SEDs to characterize the peak intensity of both the low and the high-energy components. The results have been used to derive empirical relationships that estimate the position of the two peaks from the broad-band colors (i.e. the radio to optical and optical to X-ray spectral slopes) and from the gamma-ray spectral index. Our data show that the synchrotron peak frequency $ν_p^S$ is positioned between 10$^{12.5}$ and 10$^{14.5}$ Hz in broad-lined FSRQs and between $10^{13}$ and $10^{17}$ Hz in featureless BL Lacertae objects.We find that the gamma-ray spectral slope is strongly correlated with the synchrotron peak energy and with the X-ray spectral index, as expected at first order in synchrotron - inverse Compton scenarios. However, simple homogeneous, one-zone, Synchrotron Self Compton (SSC) models cannot explain most of our SEDs, especially in the case of FSRQs and low energy peaked (LBL) BL Lacs. (...)

astro-ph.CO

Pulsar Simulations for the Fermi Large Area Telescope

Pulsars are among the prime targets for the Large Area Telescope (LAT) aboard the recently launched Fermi observatory. The LAT will study the gamma-ray Universe between 20 MeV and 300 GeV with unprecedented detail. Increasing numbers of gamma-ray pulsars are being firmly identified, yet their emission mechanisms are far from being understood. To better investigate and exploit the LAT capabilities for pulsar science, a set of new detailed pulsar simulation tools have been developed within the LAT collaboration. The structure of the pulsar simulator package PulsarSpectrum is presented here. Starting from photon distributions in energy and phase obtained from theoretical calculations or phenomenological considerations, gamma rays are generated and their arrival times at the spacecraft are determined by taking into account effects such as barycentric effects and timing noise. Pulsars in binary systems also can be simulated given orbital parameters. We present how simulations can be used for generating a realistic set of gamma rays as observed by the LAT, focusing on some case studies that show the performance of the LAT for pulsar observations.

astro-ph.HE

GLAST Status and Application to Microquasars

The Gamma-ray Large Area Space Telescope (GLAST) is a next generation high energy gamma-ray observatory due for launch in Fall 2007. The primary instrument is the Large Area Telescope (LAT), which will measure gamma-ray flux and spectra from 20 MeV to > 300 GeV and is a successor to the highly successful EGRET experiment on CGRO. The LAT will have better angular resolution, greater effective area, wider field of view and broader energy coverage than any previous experiment in this energy range. An overview of the LAT instrument design and construction is presented which includes performance estimates with particular emphasis on how these apply to strudies of microquasars. The nature and quality of the data that will be provided by the LAT is described with results from recent detailed simulations that illustrate the potential of the LAT to observe gamma ray variability and spectra.

astro-ph

Gleam: the GLAST Large Area Telescope Simulation Framework

This paper presents the simulation of the GLAST high energy gamma-ray telescope. The simulation package, written in C++, is based on the Geant4 toolkit, and it is integrated into a general framework used to process events. A detailed simulation of the electronic signals inside Silicon detectors has been provided and it is used for the particle tracking, which is handled by a dedicated software. A unique repository for the geometrical description of the detector has been realized using the XML language and a C++ library to access this information has been designed and implemented.

astro-ph

Gamma Ray Large Area Space Telescope (GLAST) Balloon Flight Data Handling Overview

The GLAST Balloon Flight Engineering Model (BFEM) represents one of 16 towers that constitute the Large Area Telescope (LAT), a high-energy (>20 MeV) gamma-ray pair-production telescope being built by an international partnership of astrophysicists and particle physicists for a satellite launch in 2006. The prototype tower consists of a Pb/Si pair-conversion tracker (TKR), a CsI hodoscopic calorimeter (CAL), an anti-coincidence detector (ACD) and an autonomous data acquisition system (DAQ). The self-triggering capabilities and performance of the detector elements have been previously characterized using positron, photon and hadron beams. External target scintillators were placed above the instrument to act as sources of hadronic showers. This paper provides a comprehensive description of the BFEM data-reduction process, from receipt of the flight data from telemetry through event reconstruction and background rejection cuts. The goals of the ground analysis presented here are to verify the functioning of the instrument and to validate the reconstruction software and the background-rejection scheme.

astro-ph