arXiv subjects

Rainer A. Leitgeb

Publications and source records attributed to Rainer A. Leitgeb.

5 recordsLinked to original sources

arXiv2026

Bridging the gap: Using deep learning to reconstruct noise-reduced super-resolved OCT images from gapped spectra

Fourier-domain (FD) optical coherence tomography (OCT) depends on broadband sources to maximize axial resolution and image quality. However, these lasers significantly drive device cost or may be unavailable at desired wavelength and bandwidth ranges. A potential solution lies in integrating multiple, more affordable sources with lower individual bandwidth into a single system. However, difficulties arise if the resulting spectrum exhibits discontinuities. In this letter, we present a method that can combine OCT images from a flexible number of spectra with arbitrary, possibly non-overlapping gaps using a neural network. Compared to low-resolution input images, reconstructed B-scans are super-resolved, preserve even fine and low-contrast details and edges, and exhibit strong noise reduction that increases with the band gap. The proposed method could thereby provide a major step towards high-quality OCT imaging using spectrally disjoint, low-bandwidth sources. In broadband settings, it can be directly applied as a Fourier-domain masked autoencoder for self-supervised image quality enhancement.

physics.optics↗

arXiv2026

Frequency-Aware Model Parameter Explorer: A new attribution method for improving explainability

State-of-the-art attribution methods rely on adversarial sample generation that applies an all-pass filter across the frequency spectrum, discarding fine-grained high-frequency information that is demonstrably important for accurate feature attribution in deep neural networks. By generating adversarial samples that selectively perturb high- and low-frequency components, we can probe which spectral features a model relies on most -- directly translating frequency-domain exploration into attribution signals. Building on this insight, we propose FAMPE (Frequency-Aware Model Parameter Explorer), a novel attribution method that introduces an FFT-based α-weighted perturbation scheme -- separately modulating high- and low-frequency components via an energy-driven spectral cutoff -- and, crucially, integrates this frequency-aware exploration directly into model parameter exploration for attribution, a connection that has not been established in prior work. Unlike prior frequency-aware adversarial approaches that target transferability or imperceptibility, FAMPE's specific formulation is designed and validated exclusively for explainability, translating spectral structure into fine-grained attribution maps without requiring any manual baseline selection. Evaluated on ImageNet across four architectures spanning CNNs and Vision Transformers, at fixed α= 0.1 FAMPE outperforms AttEXplore by 4.25% on Inception-v3 and 12.04% on MaxViT-T, with per-sample oracle selection further revealing that low-frequency-dominated images systematically benefit from high-frequency perturbations -- underscoring the potential of adaptive spectral exploration. Our ablation studies confirm that high-frequency perturbations are disproportionately responsible for attribution precision, while excessive low-frequency noise degrades global structural coherence.

cs.LG↗

arXiv2023

Multimodal imaging of the mouse eye using visible light photoacoustic ophthalmoscopy and near-infrared-II optical coherence tomography

Non-invasive imaging plays a crucial role in diagnosing and studying eye diseases. However, existing photoacoustic ophthalmoscopy (PAOM) techniques in mice have limitations due to handling restrictions, suboptimal optical properties, limited availability of light sources and permissible light fluence at the retina. This study introduces an innovative approach that utilizes Rose Bengal, a contrast agent, to enhance PAOM contrast. This enables visualization of deeper structures like the choroidal microvasculature and sclera in the mouse eye using visible light. The integration of near-infrared-II optical coherence tomography (NIR-II OCT) provides additional tissue contrast and insights into potential NIR-II PAOM capabilities. To optimize imaging, we developed a cost-effective 3D printable mouse eye phantom and a fully 3D printable tip/tilt mouse platform. This solution elevates PAOM to a user-friendly technology, which can be used to address pressing research questions concerning several ocular diseases such as myopia, glaucoma and/or age-related macular degeneration in the future.

physics.med-ph↗

arXiv2022

Data-centric AI approach to improve optic nerve head segmentation and localization in OCT en face images

The automatic detection and localization of anatomical features in retinal imaging data are relevant for many aspects. In this work, we follow a data-centric approach to optimize classifier training for optic nerve head detection and localization in optical coherence tomography en face images of the retina. We examine the effect of domain knowledge driven spatial complexity reduction on the resulting optic nerve head segmentation and localization performance. We present a machine learning approach for segmenting optic nerve head in 2D en face projections of 3D widefield swept source optical coherence tomography scans that enables the automated assessment of large amounts of data. Evaluation on manually annotated 2D en face images of the retina demonstrates that training of a standard U-Net can yield improved optic nerve head segmentation and localization performance when the underlying pixel-level binary classification task is spatially relaxed through domain knowledge.

eess.IV↗

arXiv2018

Endoscopic optical coherence tomography with a flexible fiber bundle

We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle. In comparison to current conventional forward looking probe schemes, our approach simplifies the endoscope design by avoiding the integration of any beam steering components in the distal probe end due to 2D scanning of a focused light beam over the proximal fiber bundle surface. We describe the challenges that arise when OCT imaging with a fiber bundle is performed, such as multimoding or cross-coupling. The performance of different fiber bundles with varying parameters such as numerical aperture, core size and core structure was consequently compared and artifacts that degrade the image quality were described in detail. Based on our findings, we propose an optimal fiber bundle design for endoscopic OCT imaging.

physics.med-ph↗