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Raisa Z. Freidlin

Publications and source records attributed to Raisa Z. Freidlin.

2 recordsLinked to original sources

Visual Cue Interactions in AR-Guided Needle Insertion: A Prostate Biopsy-Inspired Phantom Study

Despite the apparent simplicity of the motor action involved during percutaneous needle procedures, manipulating the tool's direction becomes challenging when clinicians cannot directly visualize internal anatomy and must rely on ultrasound images, which increase cognitive demand. Augmented reality (AR) offers the promise to assist with these tasks by providing pertinent visual information in the clinician's field of view. However, simply providing visual information that ignores meaningful visual cues can complicate depth perception and spatial understanding. In this work, we introduce and evaluate three visualization techniques for needle alignment developed during design sessions with medical experts: a localized focus-and-context window, a color-based proximity encoding, and an explicit trajectory overlay. These techniques were evaluated in a user study (n=26) including clinical experts (n=7) using a prostate-biopsy-inspired phantom. Results from this study suggest that cue effects depended on the surrounding cue configuration and user expertise. For novices, explicit trajectory overlay improved targeting accuracy and reduced retreat behavior, but its effect on completion time varied across cue configurations, with slower performance when the overlay was presented alone. For experts, the focus-and-context window reduced completion time and retreat events, while color-based proximity overlay improved completion time. Subjectively, color cues were often perceived as helpful even when their effects on accuracy were not consistent. These results suggest that AR guidance strategies for percutaneous interventions should consider user expertise and visual context.

cs.GR

A novel in vitro device to deliver induced electromagnetic fields to cell and tissue cultures

We have developed a novel in vitro instrument that can deliver intermediate frequency (100 - 400 kHz), moderate intensity (up to and exceeding 6.5 V/cm pk-pk) electric fields (EFs) to cell and tissue cultures generated using induced electromagnetic fields (EMFs) in a solenoid coil. A major application of these EFs is as an emerging cancer treatment modality. In vitro studies by Novocure Ltd. reported that intermediate frequency (100 - 300 kHz), low amplitude (1 - 3 V/cm) EFs, which they called "Tumor Treating Fields" (TTFields), had an anti-mitotic effect on glioblastoma multiforme (GBM) cells. The effect was found to increase with increasing EF amplitude. Despite continued theoretical, preclinical, and clinical study, the mechanism of action remains incompletely understood. Previous in vitro studies of "TTFields" have used attached, capacitively coupled electrodes to deliver alternating EFs to cell and tissue cultures. This contacting delivery method suffers from a poorly characterized EF profile and conductive heating that limits the duration and amplitude of the applied EFs. In contrast, our device delivers EFs with a well-characterized radial profile in a non-contacting manner, eliminating conductive heating and enabling thermally regulated EF delivery. To test and demonstrate our system, we generated continuous 200 kHz EMF with an EF amplitude profile spanning 0 - 6.5 V/cm pk-pk and applied them to human thyroid cell cultures for 72 hours. We observed moderate reduction in cell density (< 10%) at low EF amplitudes (< 4 V/cm) and a greater reduction in cell density of up to 25% at higher amplitudes (4 - 6.5 V/cm). Our device can be extended to other EF frequency and amplitude regimes. Future studies with this device should contribute to the ongoing debate about the efficacy and mechanism(s) of action of "TTFields" by better isolating the effects of EFs.

physics.bio-ph