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Ralf A. Wilke

Publications and source records attributed to Ralf A. Wilke.

5 recordsLinked to original sources

Nonparametric regression with dependent censoring or competing risks

Single-index models or time-to-event models are frequently applied in empirical research. These models are non-identifiable in presence of unknown (dependent) censoring or competing risks and do not give informative results in empirical analysis unless rather strong, non-testable restrictions hold. Little is known, whether the known robustness properties of the single-index model carry over to models with dependent censoring or competing risks. This paper shows that the ratio of partial covariate effects on the margins is identifiable in nonparametric models with unknown dependent censoring or nonparametric competing risks models with nonparametric dependence structure, provided an exclusion restriction holds. Commonly used (semi)parametric models for the margin and independent censoring, such as Cox proportional hazards, accelerated failure time or proportional odds models, can be used to obtain relative covariate effects despite their misspecified censoring mechanism. Several nonparametric estimators for the general model are introduced and their numerical properties are studied.

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On the implications of proportional hazards assumptions for competing risks modelling

The assumption of hazard rates being proportional in covariates is widely made in empirical research and extensive research has been done to develop tests of its validity. This paper does not contribute on this end. Instead, it gives new insights on the implications of proportional hazards (PH) modelling in competing risks models. It is shown that the use of a PH model for the cause-specific hazards or subdistribution hazards can strongly restrict the class of copulas and marginal hazards for being compatible with a competing risks model. The empirical researcher should be aware that working with these models can be so restrictive that only degenerate or independent risks models are compatible. Numerical results confirm that estimates of cause-specific hazards models are not informative about patterns in the data generating process.

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Identifiability and estimation of the competing risks model under exclusion restrictions

The non-identifiability of the competing risks model requires researchers to work with restrictions on the model to obtain informative results. We present a new identifiability solution based on an exclusion restriction. Many areas of applied research use methods that rely on exclusion restrcitions. It appears natural to also use them for the identifiability of competing risks models. By imposing the exclusion restriction couple with an Archimedean copula, we are able to avoid any parametric restriction on the marginal distributions. We introduce a semiparametric estimation approach for the nonparametric marginals and the parametric copula. Our simulation results demonstrate the usefulness of the suggested model, as the degree of risk dependence can be estimated without parametric restrictions on the marginal distributions.

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A single risk approach to the semiparametric copula competing risks model

A typical situation in competing risks analysis is that the researcher is only interested in a subset of risks. This paper considers a depending competing risks model with the distribution of one risk being a parametric or semi-parametric model, while the model for the other risks being unknown. Identifiability is shown for popular classes of parametric models and the semiparametric proportional hazards model. The identifiability of the parametric models does not require a covariate, while the semiparametric model requires at least one. Estimation approaches are suggested which are shown to be $\sqrt{n}$-consistent. Applicability and attractive finite sample performance are demonstrated with the help of simulations and data examples.

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Bi-log-concave distribution functions

Nonparametric statistics for distribution functions F or densities f=F' under qualitative shape constraints provides an interesting alternative to classical parametric or entirely nonparametric approaches. We contribute to this area by considering a new shape constraint: F is said to be bi-log-concave, if both log(F) and log(1 - F) are concave. Many commonly considered distributions are compatible with this constraint. For instance, any c.d.f. F with log-concave density f = F' is bi-log-concave. But in contrast to the latter constraint, bi-log-concavity allows for multimodal densities. We provide various characterizations. It is shown that combining any nonparametric confidence band for F with the new shape-constraint leads to substantial improvements, particularly in the tails. To pinpoint this, we show that these confidence bands imply non-trivial confidence bounds for arbitrary moments and the moment generating function of F.

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