SearcharxivSearch

arXiv subjects

Ramesh Nadarajah

Publications and source records attributed to Ramesh Nadarajah.

2 recordsLinked to original sources

Knowledge Augmentation via Synthetic Data: A Framework for Real-World ECG Image Classification

In real-world clinical practice, electrocardiograms (ECGs) are often captured and shared as photographs. However, publicly available ECG data, and thus most related research, relies on digital signals. This has led to a disconnect in which computer assisted interpretation of ECG cannot easily be applied to ECG images. The emergence of high-fidelity synthetic data generators has introduced practical alternatives by producing realistic, photo-like, ECG images derived from the digital signal that could help narrow this divide. To address this, we propose a novel knowledge augmentation framework that uses synthetic data generated from multiple sources to provide generalisable and accurate interpretation of ECG photographs. Our framework features two key contributions. First, we introduce a robust pre-processing pipeline designed to remove background artifacts and reduces visual differences between images. Second, we implement a two-stage training strategy: a Morphology Learning Stage, where the model captures broad morphological features from visually different, scan-like synthetic data, followed by a Task-Specific Adaptation Stage, where the model is fine-tuned on the photo-like target data. We tested the model on the British Heart Foundation Challenge dataset, to classify five common ECG findings: myocardial infarction (MI), atrial fibrillation, hypertrophy, conduction disturbance, and ST/T changes. Our approach, built upon the ConvNeXt backbone, outperforms a single-source training baseline and achieved \textbf{1st} place in the challenge with an macro-AUROC of \textbf{0.9677}. These results suggest that incorporating morphology learning from heterogeneous sources offers a more robust and generalizable paradigm than conventional single-source training.

cs.CV

Empirical investigation of multi-source cross-validation in clinical ECG classification

Traditionally, machine learning-based clinical prediction models have been trained and evaluated on patient data from a single source, such as a hospital. Cross-validation methods can be used to estimate the accuracy of such models on new patients originating from the same source, by repeated random splitting of the data. However, such estimates tend to be highly overoptimistic when compared to accuracy obtained from deploying models to sources not represented in the dataset, such as a new hospital. The increasing availability of multi-source medical datasets provides new opportunities for obtaining more comprehensive and realistic evaluations of expected accuracy through source-level cross-validation designs. In this study, we present a systematic empirical evaluation of standard K-fold cross-validation and leave-source-out cross-validation methods in a multi-source setting. We consider the task of electrocardiogram based cardiovascular disease classification, combining and harmonizing the openly available PhysioNet CinC Challenge 2021 and the Shandong Provincial Hospital datasets for our study. Our results show that K-fold cross-validation, both on single-source and multi-source data, systemically overestimates prediction performance when the end goal is to generalize to new sources. Leave-source-out cross-validation provides more reliable performance estimates, having close to zero bias though larger variability. The evaluation highlights the dangers of obtaining misleading cross-validation results on medical data and demonstrates how these issues can be mitigated when having access to multi-source data.

cs.LG