arXiv subjects

Ran Xiao

Publications and source records attributed to Ran Xiao.

16 recordsLinked to original sources

arXiv2026

Deep Learning-Based Airway Segmentation in Systemic Lupus Erythematosus Patients with Interstitial Lung Disease (SLE-ILD): A Comparative High-Resolution CT Analysis

To characterize lobar and segmental airway volume differences between systemic lupus erythematosus (SLE) patients with interstitial lung disease (ILD) and those without ILD (non-ILD) using a deep learning-based approach on non-contrast chest high-resolution CT (HRCT). Methods: A retrospective analysis was conducted on 106 SLE patients (27 SLE-ILD, 79 SLE-non-ILD) who underwent HRCT. A customized deep learning framework based on the U-Net architecture was developed to automatically segment airway structures at the lobar and segmental levels via HRCT. Volumetric measurements of lung lobes and segments derived from the segmentations were statistically compared between the two groups using two-sample t-tests (significance threshold: p < 0.05). Results: At lobar level, significant airway volume enlargement in SLE-ILD patients was observed in the right upper lobe (p=0.009) and left upper lobe (p=0.039) compared to SLE-non-ILD. At the segmental level, significant differences were found in segments including R1 (p=0.016), R3 (p<0.001), and L3 (p=0.038), with the most marked changes in the upper lung zones, while lower zones showed non-significant trends. Conclusion: Our study demonstrates that an automated deep learning-based approach can effectively quantify airway volumes on HRCT scans and reveal significant, region-specific airway dilation in patients with SLE-ILD compared to those without ILD. The pattern of involvement, predominantly affecting the upper lobes and specific segments, highlights a distinct topographic phenotype of SLE-ILD and implicates airway structural alterations as a potential biomarker for disease presence. This AI-powered quantitative imaging biomarker holds promise for enhancing the early detection and monitoring of ILD in the SLE population, ultimately contributing to more personalized patient management.

eess.IV↗

arXiv2025

Generalist vs Specialist Time Series Foundation Models: Investigating Potential Emergent Behaviors in Assessing Human Health Using PPG Signals

Foundation models are large-scale machine learning models that are pre-trained on massive amounts of data and can be adapted for various downstream tasks. They have been extensively applied to tasks in Natural Language Processing and Computer Vision with models such as GPT, BERT, and CLIP. They are now also increasingly gaining attention in time-series analysis, particularly for physiological sensing. However, most time series foundation models are specialist models - with data in pre-training and testing of the same type, such as Electrocardiogram, Electroencephalogram, and Photoplethysmogram (PPG). Recent works, such as MOMENT, train a generalist time series foundation model with data from multiple domains, such as weather, traffic, and electricity. This paper aims to conduct a comprehensive benchmarking study to compare the performance of generalist and specialist models, with a focus on PPG signals. Through an extensive suite of total 51 tasks covering cardiac state assessment, laboratory value estimation, and cross-modal inference, we comprehensively evaluate both models across seven dimensions, including win score, average performance, feature quality, tuning gain, performance variance, transferability, and scalability. These metrics jointly capture not only the models' capability but also their adaptability, robustness, and efficiency under different fine-tuning strategies, providing a holistic understanding of their strengths and limitations for diverse downstream scenarios. In a full-tuning scenario, we demonstrate that the specialist model achieves a 27% higher win score. Finally, we provide further analysis on generalization, fairness, attention visualizations, and the importance of training data choice.

cs.LG↗

arXiv2025

Wav2Arrest 2.0: Long-Horizon Cardiac Arrest Prediction with Time-to-Event Modeling, Identity-Invariance, and Pseudo-Lab Alignment

High-frequency physiological waveform modality offers deep, real-time insights into patient status. Recently, physiological foundation models based on Photoplethysmography (PPG), such as PPG-GPT, have been shown to predict critical events, including Cardiac Arrest (CA). However, their powerful representation still needs to be leveraged suitably, especially when the downstream data/label is scarce. We offer three orthogonal improvements to improve PPG-only CA systems by using minimal auxiliary information. First, we propose to use time-to-event modeling, either through simple regression to the event onset time or by pursuing fine-grained discrete survival modeling. Second, we encourage the model to learn CA-focused features by making them patient-identity invariant. This is achieved by first training the largest-scale de-identified biometric identification model, referred to as the p-vector, and subsequently using it adversarially to deconfound cues, such as person identity, that may cause overfitting through memorization. Third, we propose regression on the pseudo-lab values generated by pre-trained auxiliary estimator networks. This is crucial since true blood lab measurements, such as lactate, sodium, troponin, and potassium, are collected sparingly. Via zero-shot prediction, the auxiliary networks can enrich cardiac arrest waveform labels and generate pseudo-continuous estimates as targets. Our proposals can independently improve the 24-hour time-averaged AUC from the 0.74 to the 0.78-0.80 range. We primarily improve over longer time horizons with minimal degradation near the event, thus pushing the Early Warning System research. Finally, we pursue multi-task formulation and diagnose it with a high gradient conflict rate among competing losses, which we alleviate via the PCGrad optimization technique.

cs.LG↗

arXiv2025

Learning ECG Representations via Poly-Window Contrastive Learning

Electrocardiogram (ECG) analysis is foundational for cardiovascular disease diagnosis, yet the performance of deep learning models is often constrained by limited access to annotated data. Self-supervised contrastive learning has emerged as a powerful approach for learning robust ECG representations from unlabeled signals. However, most existing methods generate only pairwise augmented views and fail to leverage the rich temporal structure of ECG recordings. In this work, we present a poly-window contrastive learning framework. We extract multiple temporal windows from each ECG instance to construct positive pairs and maximize their agreement via statistics. Inspired by the principle of slow feature analysis, our approach explicitly encourages the model to learn temporally invariant and physiologically meaningful features that persist across time. We validate our approach through extensive experiments and ablation studies on the PTB-XL dataset. Our results demonstrate that poly-window contrastive learning consistently outperforms conventional two-view methods in multi-label superclass classification, achieving higher AUROC (0.891 vs. 0.888) and F1 scores (0.680 vs. 0.679) while requiring up to four times fewer pre-training epochs (32 vs. 128) and 14.8% in total wall clock pre-training time reduction. Despite processing multiple windows per sample, we achieve a significant reduction in the number of training epochs and total computation time, making our method practical for training foundational models. Through extensive ablations, we identify optimal design choices and demonstrate robustness across various hyperparameters. These findings establish poly-window contrastive learning as a highly efficient and scalable paradigm for automated ECG analysis and provide a promising general framework for self-supervised representation learning in biomedical time-series data.

cs.LG↗

arXiv2025

Bronchovascular Tree-Guided Weakly Supervised Learning Method for Pulmonary Segment Segmentation

Pulmonary segment segmentation is crucial for cancer localization and surgical planning. However, the pixel-wise annotation of pulmonary segments is laborious, as the boundaries between segments are indistinguishable in medical images. To this end, we propose a weakly supervised learning (WSL) method, termed Anatomy-Hierarchy Supervised Learning (AHSL), which consults the precise clinical anatomical definition of pulmonary segments to perform pulmonary segment segmentation. Since pulmonary segments reside within the lobes and are determined by the bronchovascular tree, i.e., artery, airway and vein, the design of the loss function is founded on two principles. First, segment-level labels are utilized to directly supervise the output of the pulmonary segments, ensuring that they accurately encompass the appropriate bronchovascular tree. Second, lobe-level supervision indirectly oversees the pulmonary segment, ensuring their inclusion within the corresponding lobe. Besides, we introduce a two-stage segmentation strategy that incorporates bronchovascular priori information. Furthermore, a consistency loss is proposed to enhance the smoothness of segment boundaries, along with an evaluation metric designed to measure the smoothness of pulmonary segment boundaries. Visual inspection and evaluation metrics from experiments conducted on a private dataset demonstrate the effectiveness of our method.

eess.IV↗

arXiv2025

Fusion of ECG Foundation Model Embeddings to Improve Early Detection of Acute Coronary Syndromes

Acute Coronary Syndrome (ACS) is a life-threatening cardiovascular condition where early and accurate diagnosis is critical for effective treatment and improved patient outcomes. This study explores the use of ECG foundation models, specifically ST-MEM and ECG-FM, to enhance ACS risk assessment using prehospital ECG data collected in ambulances. Both models leverage self-supervised learning (SSL), with ST-MEM using a reconstruction-based approach and ECG-FM employing contrastive learning, capturing unique spatial and temporal ECG features. We evaluate the performance of these models individually and through a fusion approach, where their embeddings are combined for enhanced prediction. Results demonstrate that both foundation models outperform a baseline ResNet-50 model, with the fusion-based approach achieving the highest performance (AUROC: 0.843 +/- 0.006, AUCPR: 0.674 +/- 0.012). These findings highlight the potential of ECG foundation models for early ACS detection and motivate further exploration of advanced fusion strategies to maximize complementary feature utilization.

eess.SP↗

arXiv2025

Continuous Cardiac Arrest Prediction in ICU using PPG Foundation Model

Non-invasive patient monitoring for tracking and predicting adverse acute health events is an emerging area of research. We pursue in-hospital cardiac arrest (IHCA) prediction using only single-channel finger photoplethysmography (PPG) signals. Our proposed two-stage model Feature Extractor-Aggregator Network (FEAN) leverages powerful representations from pre-trained PPG foundation models (PPG-GPT of size up to 1 Billion) stacked with sequential classification models. We propose two FEAN variants ("1H", "FH") which use the latest one-hour and (max) 24-hour history to make decisions respectively. Our study is the first to present IHCA prediction results in ICU patients using only unimodal (continuous PPG signal) waveform deep representations. With our best model, we obtain an average of 0.79 AUROC over 24~h prediction window before CA event onset with our model peaking performance at 0.82 one hour before CA. We also provide a comprehensive analysis of our model through architectural tuning and PaCMAP visualization of patient health trajectory in latent space.

cs.LG↗

arXiv2025

Baichuan-Omni-1.5 Technical Report

We introduce Baichuan-Omni-1.5, an omni-modal model that not only has omni-modal understanding capabilities but also provides end-to-end audio generation capabilities. To achieve fluent and high-quality interaction across modalities without compromising the capabilities of any modality, we prioritized optimizing three key aspects. First, we establish a comprehensive data cleaning and synthesis pipeline for multimodal data, obtaining about 500B high-quality data (text, audio, and vision). Second, an audio-tokenizer (Baichuan-Audio-Tokenizer) has been designed to capture both semantic and acoustic information from audio, enabling seamless integration and enhanced compatibility with MLLM. Lastly, we designed a multi-stage training strategy that progressively integrates multimodal alignment and multitask fine-tuning, ensuring effective synergy across all modalities. Baichuan-Omni-1.5 leads contemporary models (including GPT4o-mini and MiniCPM-o 2.6) in terms of comprehensive omni-modal capabilities. Notably, it achieves results comparable to leading models such as Qwen2-VL-72B across various multimodal medical benchmarks.

cs.CL↗

arXiv2024

SQUWA: Signal Quality Aware DNN Architecture for Enhanced Accuracy in Atrial Fibrillation Detection from Noisy PPG Signals

Atrial fibrillation (AF), a common cardiac arrhythmia, significantly increases the risk of stroke, heart disease, and mortality. Photoplethysmography (PPG) offers a promising solution for continuous AF monitoring, due to its cost efficiency and integration into wearable devices. Nonetheless, PPG signals are susceptible to corruption from motion artifacts and other factors often encountered in ambulatory settings. Conventional approaches typically discard corrupted segments or attempt to reconstruct original signals, allowing for the use of standard machine learning techniques. However, this reduces dataset size and introduces biases, compromising prediction accuracy and the effectiveness of continuous monitoring. We propose a novel deep learning model, Signal Quality Weighted Fusion of Attentional Convolution and Recurrent Neural Network (SQUWA), designed to learn how to retain accurate predictions from partially corrupted PPG. Specifically, SQUWA innovatively integrates an attention mechanism that directly considers signal quality during the learning process, dynamically adjusting the weights of time series segments based on their quality. This approach enhances the influence of higher-quality segments while reducing that of lower-quality ones, effectively utilizing partially corrupted segments. This approach represents a departure from the conventional methods that exclude such segments, enabling the utilization of a broader range of data, which has great implications for less disruption when monitoring of AF risks and more accurate estimation of AF burdens. Our extensive experiments show that SQUWA outperform existing PPG-based models, achieving the highest AUCPR of 0.89 with label noise mitigation. This also exceeds the 0.86 AUCPR of models trained with using both electrocardiogram (ECG) and PPG data.

eess.SP↗

arXiv2024

Evaluation of General Large Language Models in Contextually Assessing Semantic Concepts Extracted from Adult Critical Care Electronic Health Record Notes

The field of healthcare has increasingly turned its focus towards Large Language Models (LLMs) due to their remarkable performance. However, their performance in actual clinical applications has been underexplored. Traditional evaluations based on question-answering tasks don't fully capture the nuanced contexts. This gap highlights the need for more in-depth and practical assessments of LLMs in real-world healthcare settings. Objective: We sought to evaluate the performance of LLMs in the complex clinical context of adult critical care medicine using systematic and comprehensible analytic methods, including clinician annotation and adjudication. Methods: We investigated the performance of three general LLMs in understanding and processing real-world clinical notes. Concepts from 150 clinical notes were identified by MetaMap and then labeled by 9 clinicians. Each LLM's proficiency was evaluated by identifying the temporality and negation of these concepts using different prompts for an in-depth analysis. Results: GPT-4 showed overall superior performance compared to other LLMs. In contrast, both GPT-3.5 and text-davinci-003 exhibit enhanced performance when the appropriate prompting strategies are employed. The GPT family models have demonstrated considerable efficiency, evidenced by their cost-effectiveness and time-saving capabilities. Conclusion: A comprehensive qualitative performance evaluation framework for LLMs is developed and operationalized. This framework goes beyond singular performance aspects. With expert annotations, this methodology not only validates LLMs' capabilities in processing complex medical data but also establishes a benchmark for future LLM evaluations across specialized domains.

cs.CL↗

arXiv2023

Reconsideration on evaluation of machine learning models in continuous monitoring using wearables

This paper explores the challenges in evaluating machine learning (ML) models for continuous health monitoring using wearable devices beyond conventional metrics. We state the complexities posed by real-world variability, disease dynamics, user-specific characteristics, and the prevalence of false notifications, necessitating novel evaluation strategies. Drawing insights from large-scale heart studies, the paper offers a comprehensive guideline for robust ML model evaluation on continuous health monitoring.

cs.LG↗

arXiv2023

Learning From Alarms: A Robust Learning Approach for Accurate Photoplethysmography-Based Atrial Fibrillation Detection using Eight Million Samples Labeled with Imprecise Arrhythmia Alarms

Atrial fibrillation (AF) is a common cardiac arrhythmia with serious health consequences if not detected and treated early. Detecting AF using wearable devices with photoplethysmography (PPG) sensors and deep neural networks has demonstrated some success using proprietary algorithms in commercial solutions. However, further advancement of this paradigm of continuous AF detection in ambulatory settings, towards a population-wide screening use case, still faces several challenges, one of which is the lack of large-scale labeled training data. To address this challenge, in this study, we propose to leverage AF alarms from bedside patient monitors to label concurrent PPG signals, resulting in the largest PPG-AF dataset so far (8.5M 30-second records from 24100 patients) and demonstrating a practical approach to build large labeled PPG datasets. Furthermore, we recognize that the AF labels thus obtained contain errors because of false AF alarms generated from imperfect built-in algorithms from bedside monitors. Dealing with label noise with unknown distribution characteristics in this case requires advanced algorithms. We, therefore, introduce and open source a novel loss design, the cluster membership consistency (CMC) loss, to mitigate label errors. By comparing CMC with state-of-the-art methods selected from a noisy label competition, we demonstrate its superiority in multiple aspects including handling label noise in PPG data, resilience to poor-quality signals, and computational efficiency.

eess.SP↗

arXiv2023

Photoplethysmography based atrial fibrillation detection: an updated review from July 2019

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with significant health ramifications, including an elevated susceptibility to ischemic stroke, heart disease, and heightened mortality. Photoplethysmography (PPG) has emerged as a promising technology for continuous AF monitoring for its cost-effectiveness and widespread integration into wearable devices. Our team previously conducted an exhaustive review on PPG-based AF detection before June 2019. However, since then, more advanced technologies have emerged in this field. This paper offers a comprehensive review of the latest advancements in PPG-based AF detection, utilizing digital health and artificial intelligence (AI) solutions, within the timeframe spanning from July 2019 to December 2022. Through extensive exploration of scientific databases, we have identified 59 pertinent studies. Our comprehensive review encompasses an in-depth assessment of the statistical methodologies, traditional machine learning techniques, and deep learning approaches employed in these studies. In addition, we address the challenges encountered in the domain of PPG-based AF detection. Furthermore, we maintain a dedicated website to curate the latest research in this area, with regular updates on a regular basis.

eess.SP↗

arXiv2022

Log-Spectral Matching GAN: PPG-based Atrial Fibrillation Detection can be Enhanced by GAN-based Data Augmentation with Integration of Spectral Loss

Photoplethysmography (PPG) is a ubiquitous physiological measurement that detects beat-to-beat pulsatile blood volume changes and hence has a potential for monitoring cardiovascular conditions, particularly in ambulatory settings. A PPG dataset that is created for a particular use case is often imbalanced, due to a low prevalence of the pathological condition it targets to predict and the paroxysmal nature of the condition as well. To tackle this problem, we propose log-spectral matching GAN (LSM-GAN), a generative model that can be used as a data augmentation technique to alleviate the class imbalance in a PPG dataset to train a classifier. LSM-GAN utilizes a novel generator that generates a synthetic signal without a up-sampling process of input white noises, as well as adds the mismatch between real and synthetic signals in frequency domain to the conventional adversarial loss. In this study, experiments are designed focusing on examining how the influence of LSM-GAN as a data augmentation technique on one specific classification task - atrial fibrillation (AF) detection using PPG. We show that by taking spectral information into consideration, LSM-GAN as a data augmentation solution can generate more realistic PPG signals. The code of LSM-GAN is available at https://github.com/chengding0713/Log-Spectral-matching-GAN.

eess.SP↗

arXiv2017

A segmented conical electric lens for optimization of the beam spot of the low-energy muon facility at PSI: a Geant4 simulation analysis

The low-energy muon facility at PSI provides nearly fully polarized positive muons with tunable energies in the keV range to carry out muon spin rotation (LE-muSR) experiments with nanometer depth resolution on thin films, heterostructures, and near-surface regions. The low-energy muon beam is focused and transported to the sample by electrostatic lenses. In order to achieve a minimum beam spot size at the sample position and to enable the steering of the beam in the horizontal and vertical direction, a special electrostatic device has been implemented close to the sample position. It consists of a cylinder at ground potential followed by four conically shaped electrodes, which can be operated at different electric potential. In LE-muSR experiments, an electric field at the sample along the beam direction can be applied to accelerate/decelerate muons to different energies (0.5-30 keV). Additionally, a horizontal or vertical magnetic field can be superimposed for transverse or longitudinal field muSR experiments. The focusing properties of the conical lens in the presence of these additional electric and magnetic fields have been investigated and optimized by Geant4 simulations. Some experimental tests were also performed and show that the simulation well describes the experimental setup.

physics.acc-ph↗

arXiv2016

A new muon-pion collection and transport system design using superconducting solenoids based on CSNS

A new muon and pion capture system is proposed for the China Spallation Neutron Source (CSNS), currently under construction. Using about 4\% of the pulsed proton beam (1.6 GeV, 4 kW and 1 Hz) of CSNS to bombard a cylindrical graphite target inside a superconducting solenoid, both surface muons and pions can be acquired. The acceptance of this novel capture system - a graphite target wrapped up by a superconducting solenoid - is larger than the normal muon beam lines using quadrupoles at one side of the separated muon target. The muon and pion production at different capture magnetic fields was calculated using Geant4. The bending angle of the capture solenoid with respect to the proton beam was also optimized in simulation to achieve more muons and pions. Based on the layout of the muon experimental area reserved at the CSNS project, a preliminary muon beam line was designed with multi-purpose muon spin rotation areas (surface, decay and low-energy muons). Finally, high-flux surface muons (10$^8$/s) and decay muons (10$^9$/s) simulated by G4beamline will be available at the end of the decay solenoid based on the first phase of CSNS. This collection and transport system will be a very effective beam line at a proton current of 2.5 $μ$A.

physics.acc-ph↗