arXiv subjects

Ravi Madduri

Publications and source records attributed to Ravi Madduri.

15 recordsLinked to original sources

arXiv2026

Towards Global Federated Genome-Wide Association Meta-Analysis Using GA4GH TES

Genome-wide association studies (GWAS) gain statistical power from large, ancestrally diverse cohorts, but privacy regulations and data-residency constraints often prevent genomic data from being centrally pooled across institutional or national borders. We present a privacy-preserving federated GWAS meta-analysis pipeline built on the APPFL framework, in which each site computes local GWAS summary statistics and transmits only aggregate results, never individual-level genotypes. Analysis is executed through a global network of Global Alliance for Genomics and Health (GA4GH) Task Execution Service (TES) endpoints, which allows computation to move to the data rather than the reverse. The server performs inverse-variance-weighted fixed-effect meta-analysis and returns aggregated results to all sites, while HiveWatch, our developed geographic observability toolkit, provides real-time monitoring of distributed task execution. In a five-site simulation over 100,000 synthetic individuals and roughly 240,000 variants for Type 2 Diabetes and Body Mass Index, the federated meta-analysis reproduces the association signal expected from a pooled analysis without centralizing any genotype data, showing that standards-based task execution and federated learning enables a practical privacy-preserving infrastructure for international GWAS meta-analysis.

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arXiv2026

Federated Learning on the American Science Cloud using APPFL

The American Science Cloud (AmSC), established under the Genesis Mission of the U.S. Department of Energy (DOE), aims to integrate DOE high-performance computing systems, experimental facilities, and data resources into a single, coordinated, AI-driven discovery platform. AmSC's early services focus on curated artifacts, such as gated inference access to hosted models, experiment tracking, and function execution across computing facilities. However, what these services lack is a means to train a model across organizational boundaries where data cannot be centralized due to policy, privacy, or scale. This is, by definition, a use case for federated learning (FL) and a growing class of scientific AI. In this paper, we show that this gap can be bridged by deploying the orchestration logic of the Advanced Privacy-Preserving Federated Learning (APPFL) framework as a scalable cloud service on top of the primitives AmSC already provides: project-scoped authentication that supports secure and reliable federation membership, function execution that drives distributed training at each site, experiment tracking that records round-level performance, and finally, the model-hosting and inference infrastructure that can be leveraged to distribute the federated trained models to authorized participants. We argue that offering federated computing as an important AmSC service would unlock privacy-constrained scientific collaborations, enabling public-private partnerships in model building while exercising and enhancing the platform's own federated infrastructure.

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arXiv2026

FedQueue: Queue-Aware Federated Learning for Cross-Facility HPC Training

Federated learning (FL) across multiple HPC facilities faces stochastic admission delays from batch schedulers that dominate wall-clock time. Synchronous FL suffers from severe stragglers, while asynchronous FL accumulates stale updates when queues spike. We propose FedQueue, a queue-aware FL protocol that incorporates scheduler delays directly into training and aggregation, which (i) predicts per-facility queue delays online to budget local work, (ii) applies cutoff-based admission that buffers late arrivals to bound staleness, and (iii) performs staleness-aware aggregation to stabilize heterogeneous local workloads. We prove the convergence for non-convex objectives at rate $\mathcal{O}(1/\sqrt{R})$ under bounded staleness, and show that the admission controls yield bounded staleness with high probability under queue-prediction error. Real-world cross-facility deployment of FedQueue shows 20.5% improvement over baseline algorithms. Controlled queue simulations demonstrate robust improvement over the baselines; in particular, up to 60% reduction in time to reach a target accuracy level under high queue variance and non-IID partitions.

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arXiv2026

Scalable Cross-Facility Federated Learning for Scientific Foundation Models on Multiple Supercomputers

Artificial Intelligence for scientific applications increasingly requires training large models on data that cannot be centralized due to privacy constraints, data sovereignty, or the sheer volume of data generated. Federated learning (FL) addresses this by enabling collaborative training without centralizing raw data, but scientific applications demand model scales that requires extensive computing resources, typically offered at High Performance Computing (HPC) facilities. Deploying FL experiments across HPC facilities introduces challenges beyond cloud or enterprise settings. We present a comprehensive cross-facility FL framework for heterogeneous HPC environments, built on Advanced Privacy-Preserving Federated Learning (APPFL) framework with Globus Compute and Transfer orchestration, and evaluate it across four U.S. Department of Energy (DOE) leadership-class supercomputers. We demonstrate that FL experiments across HPC facilities are practically achievable, characterize key sources of heterogeneity impacting the training performance, and show that algorithmic choices matter significantly under realistic HPC scheduling conditions. We validate the scientific applicability by fine-tuning a large language model on a chemistry instruction dataset, and identify scheduler-aware algorithm design as a critical open challenge for future deployments.

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arXiv2025

Experiences Building Enterprise-Level Privacy-Preserving Federated Learning to Power AI for Science

Federated learning (FL) is a promising approach to enabling collaborative model training without centralized data sharing, a crucial requirement in scientific domains where data privacy, ownership, and compliance constraints are critical. However, building user-friendly enterprise-level FL frameworks that are both scalable and privacy-preserving remains challenging, especially when bridging the gap between local prototyping and distributed deployment across heterogeneous client computing infrastructures. In this paper, based on our experiences building the Advanced Privacy-Preserving Federated Learning (APPFL) framework, we present our vision for an enterprise-grade, privacy-preserving FL framework designed to scale seamlessly across computing environments. We identify several key capabilities that such a framework must provide: (1) Scalable local simulation and prototyping to accelerate experimentation and algorithm design; (2) seamless transition from simulation to deployment; (3) distributed deployment across diverse, real-world infrastructures, from personal devices to cloud clusters and HPC systems; (4) multi-level abstractions that balance ease of use and research flexibility; and (5) comprehensive privacy and security through techniques such as differential privacy, secure aggregation, robust authentication, and confidential computing. We further discuss architectural designs to realize these goals. This framework aims to bridge the gap between research prototypes and enterprise-scale deployment, enabling scalable, reliable, and privacy-preserving AI for science.

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arXiv2025

CADRE: Customizable Assurance of Data Readiness in Privacy-Preserving Federated Learning

Privacy-Preserving Federated Learning (PPFL) is a decentralized machine learning approach where multiple clients train a model collaboratively. PPFL preserves the privacy and security of a client's data without exchanging it. However, ensuring that data at each client is of high quality and ready for federated learning (FL) is a challenge due to restricted data access. In this paper, we introduce CADRE (Customizable Assurance of Data Readiness) for federated learning (FL), a novel framework that allows users to define custom data readiness (DR) metrics, rules, and remedies tailored to specific FL tasks. CADRE generates comprehensive DR reports based on the user-defined metrics, rules, and remedies to ensure datasets are prepared for FL while preserving privacy. We demonstrate a practical application of CADRE by integrating it into an existing PPFL framework. We conducted experiments across six datasets and addressed seven different DR issues. The results illustrate the versatility and effectiveness of CADRE in ensuring DR across various dimensions, including data quality, privacy, and fairness. This approach enhances the performance and reliability of FL models as well as utilizes valuable resources.

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arXiv2025

FedCostAware: Enabling Cost-Aware Federated Learning on the Cloud

Federated learning (FL) is a distributed machine learning (ML) approach that allows multiple clients to collaboratively train ML models without exchanging original training data, offering a solution that is particularly valuable in sensitive domains such as biomedicine. However, training robust FL models often requires substantial computing resources from participating clients, which may not be readily available at institutions such as hospitals. While cloud platforms offer on-demand access to such resources, their usage can incur significant costs, particularly in distributed training scenarios where poor coordination strategies can lead to substantial resource wastage. To address this, we introduce FedCostAware, a cost-aware scheduling algorithm designed to optimize synchronous FL on cloud spot instances. FedCostAware addresses the challenges of training on spot instances and different client budgets by employing intelligent management of the lifecycle of spot instances. This approach minimizes resource idle time and overall expenses. Comprehensive experiments across multiple datasets demonstrate that FedCostAware significantly reduces cloud computing costs compared to conventional spot and on-demand schemes, enhancing the accessibility and affordability of FL.

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arXiv2025

AIDRIN 2.0: A Framework to Assess Data Readiness for AI

AI Data Readiness Inspector (AIDRIN) is a framework to evaluate and improve data preparedness for AI applications. It addresses critical data readiness dimensions such as data quality, bias, fairness, and privacy. This paper details enhancements to AIDRIN by focusing on user interface improvements and integration with a privacy-preserving federated learning (PPFL) framework. By refining the UI and enabling smooth integration with decentralized AI pipelines, AIDRIN becomes more accessible and practical for users with varying technical expertise. Integrating with an existing PPFL framework ensures that data readiness and privacy are prioritized in federated learning environments. A case study involving a real-world dataset demonstrates AIDRIN's practical value in identifying data readiness issues that impact AI model performance.

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arXiv2024

Advances in Privacy Preserving Federated Learning to Realize a Truly Learning Healthcare System

The concept of a learning healthcare system (LHS) envisions a self-improving network where multimodal data from patient care are continuously analyzed to enhance future healthcare outcomes. However, realizing this vision faces significant challenges in data sharing and privacy protection. Privacy-Preserving Federated Learning (PPFL) is a transformative and promising approach that has the potential to address these challenges by enabling collaborative learning from decentralized data while safeguarding patient privacy. This paper proposes a vision for integrating PPFL into the healthcare ecosystem to achieve a truly LHS as defined by the Institute of Medicine (IOM) Roundtable.

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arXiv2024

Advances in APPFL: A Comprehensive and Extensible Federated Learning Framework

Federated learning (FL) is a distributed machine learning paradigm enabling collaborative model training while preserving data privacy. In today's landscape, where most data is proprietary, confidential, and distributed, FL has become a promising approach to leverage such data effectively, particularly in sensitive domains such as medicine and the electric grid. Heterogeneity and security are the key challenges in FL, however, most existing FL frameworks either fail to address these challenges adequately or lack the flexibility to incorporate new solutions. To this end, we present the recent advances in developing APPFL, an extensible framework and benchmarking suite for federated learning, which offers comprehensive solutions for heterogeneity and security concerns, as well as user-friendly interfaces for integrating new algorithms or adapting to new applications. We demonstrate the capabilities of APPFL through extensive experiments evaluating various aspects of FL, including communication efficiency, privacy preservation, computational performance, and resource utilization. We further highlight the extensibility of APPFL through case studies in vertical, hierarchical, and decentralized FL. APPFL is fully open-sourced on GitHub at https://github.com/APPFL/APPFL.

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arXiv2024

AI Data Readiness Inspector (AIDRIN) for Quantitative Assessment of Data Readiness for AI

"Garbage In Garbage Out" is a universally agreed quote by computer scientists from various domains, including Artificial Intelligence (AI). As data is the fuel for AI, models trained on low-quality, biased data are often ineffective. Computer scientists who use AI invest a considerable amount of time and effort in preparing the data for AI. However, there are no standard methods or frameworks for assessing the "readiness" of data for AI. To provide a quantifiable assessment of the readiness of data for AI processes, we define parameters of AI data readiness and introduce AIDRIN (AI Data Readiness Inspector). AIDRIN is a framework covering a broad range of readiness dimensions available in the literature that aid in evaluating the readiness of data quantitatively and qualitatively. AIDRIN uses metrics in traditional data quality assessment such as completeness, outliers, and duplicates for data evaluation. Furthermore, AIDRIN uses metrics specific to assess data for AI, such as feature importance, feature correlations, class imbalance, fairness, privacy, and FAIR (Findability, Accessibility, Interoperability, and Reusability) principle compliance. AIDRIN provides visualizations and reports to assist data scientists in further investigating the readiness of data. The AIDRIN framework enhances the efficiency of the machine learning pipeline to make informed decisions on data readiness for AI applications.

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arXiv2024

FedCompass: Efficient Cross-Silo Federated Learning on Heterogeneous Client Devices using a Computing Power Aware Scheduler

Cross-silo federated learning offers a promising solution to collaboratively train robust and generalized AI models without compromising the privacy of local datasets, e.g., healthcare, financial, as well as scientific projects that lack a centralized data facility. Nonetheless, because of the disparity of computing resources among different clients (i.e., device heterogeneity), synchronous federated learning algorithms suffer from degraded efficiency when waiting for straggler clients. Similarly, asynchronous federated learning algorithms experience degradation in the convergence rate and final model accuracy on non-identically and independently distributed (non-IID) heterogeneous datasets due to stale local models and client drift. To address these limitations in cross-silo federated learning with heterogeneous clients and data, we propose FedCompass, an innovative semi-asynchronous federated learning algorithm with a computing power-aware scheduler on the server side, which adaptively assigns varying amounts of training tasks to different clients using the knowledge of the computing power of individual clients. FedCompass ensures that multiple locally trained models from clients are received almost simultaneously as a group for aggregation, effectively reducing the staleness of local models. At the same time, the overall training process remains asynchronous, eliminating prolonged waiting periods from straggler clients. Using diverse non-IID heterogeneous distributed datasets, we demonstrate that FedCompass achieves faster convergence and higher accuracy than other asynchronous algorithms while remaining more efficient than synchronous algorithms when performing federated learning on heterogeneous clients. The source code for FedCompass is available at https://github.com/APPFL/FedCompass.

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arXiv2024

Secure Federated Learning Across Heterogeneous Cloud and High-Performance Computing Resources -- A Case Study on Federated Fine-tuning of LLaMA 2

Federated learning enables multiple data owners to collaboratively train robust machine learning models without transferring large or sensitive local datasets by only sharing the parameters of the locally trained models. In this paper, we elaborate on the design of our Advanced Privacy-Preserving Federated Learning (APPFL) framework, which streamlines end-to-end secure and reliable federated learning experiments across cloud computing facilities and high-performance computing resources by leveraging Globus Compute, a distributed function as a service platform, and Amazon Web Services. We further demonstrate the use case of APPFL in fine-tuning a LLaMA 2 7B model using several cloud resources and supercomputers.

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arXiv2023

Enabling End-to-End Secure Federated Learning in Biomedical Research on Heterogeneous Computing Environments with APPFLx

Facilitating large-scale, cross-institutional collaboration in biomedical machine learning projects requires a trustworthy and resilient federated learning (FL) environment to ensure that sensitive information such as protected health information is kept confidential. In this work, we introduce APPFLx, a low-code FL framework that enables the easy setup, configuration, and running of FL experiments across organizational and administrative boundaries while providing secure end-to-end communication, privacy-preserving functionality, and identity management. APPFLx is completely agnostic to the underlying computational infrastructure of participating clients. We demonstrate the capability of APPFLx as an easy-to-use framework for accelerating biomedical studies across institutions and healthcare systems while maintaining the protection of private medical data in two case studies: (1) predicting participant age from electrocardiogram (ECG) waveforms, and (2) detecting COVID-19 disease from chest radiographs. These experiments were performed securely across heterogeneous compute resources, including a mixture of on-premise high-performance computing and cloud computing, and highlight the role of federated learning in improving model generalizability and performance when aggregating data from multiple healthcare systems. Finally, we demonstrate that APPFLx serves as a convenient and easy-to-use framework for accelerating biomedical studies across institutions and healthcare system while maintaining the protection of private medical data.

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arXiv2023

APPFLx: Providing Privacy-Preserving Cross-Silo Federated Learning as a Service

Cross-silo privacy-preserving federated learning (PPFL) is a powerful tool to collaboratively train robust and generalized machine learning (ML) models without sharing sensitive (e.g., healthcare of financial) local data. To ease and accelerate the adoption of PPFL, we introduce APPFLx, a ready-to-use platform that provides privacy-preserving cross-silo federated learning as a service. APPFLx employs Globus authentication to allow users to easily and securely invite trustworthy collaborators for PPFL, implements several synchronous and asynchronous FL algorithms, streamlines the FL experiment launch process, and enables tracking and visualizing the life cycle of FL experiments, allowing domain experts and ML practitioners to easily orchestrate and evaluate cross-silo FL under one platform. APPFLx is available online at https://appflx.link

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