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Raymond Dolan

Publications and source records attributed to Raymond Dolan.

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A clinically validated framework for auditing AI chatbot behavior in mental health interactions

Millions of users turn to consumer AI chatbots to discuss emotional, behavioral, and mental-health concerns, creating an urgent need for rigorous and scalable safety evaluations. Here we introduce SIM-VAIL, a clinically validated framework for auditing chatbot behavior in mental-health contexts. SIM-VAIL simulates users with specific psychiatric vulnerabilities and conversational intents, engages them in multi-turn conversations with frontier AI chatbots (including Claude, ChatGPT, Gemini, Grok and Llama models), and scores each exchange across 13 clinically grounded risk dimensions. Across 810 conversations, spanning 9 target chatbots and 30 simulated user profiles, concerning behavior in target chatbots was widespread, albeit reduced in newer models. Concerning behavior varied by user vulnerability and conversational intent, accumulated over turns, and could be reduced by interventions at early escalation points. Risk was highest when otherwise supportive chatbot behaviors reinforced the psychological mechanisms underlying the simulated user's vulnerability, a pattern we term a Vulnerability Amplifying Interaction Loop (VAIL). SIM-VAIL provides a scalable framework for mapping mental health risk across users, chatbots, and conversational trajectories, offering a foundation for targeted safety improvements.

q-bio.NC

A region-specific brain dysfunction underlies cognitive impairment in long COVID brain fog

Long COVID "brain fog" is a common and debilitating subjective syndrome often associated with persistent cognitive impairment after COVID-19 infection. Here we identify a specific regional brain dysfunction that mediates this cognitive impairment and provide evidence that targeted neuromodulation improves this deficit. In 120 patients with long COVID brain fog, we found an aberrant perceptual processing pattern. Patients with more severe brain fog committed significantly more false alarms (impulsive responses to non-signals) despite preserved overall accuracy. Both high-density (128-channel) EEG and structural MRI analyses provided converging evidence of a right inferior insula deficit, characterized by a blunted neural monitoring signal and cortical atrophy. We confirmed this deficit in a separate 796-participant UK Biobank longitudinal COVID re-imaging cohort, where COVID-19 survivors also showed selective impairment on a perceptual processing task and corresponding longitudinal atrophy of the right inferior insula compared with healthy controls. Finally, in a proof-of-principle randomized, sham-controlled trial (n = 40), a non-invasive, excitatory theta-burst ultrasound stimulation protocol targeting the right inferior insula rescued the perceptual deficit by reducing false alarms. These findings provide evidence of a causal role for right inferior insula dysfunction in long COVID-related perceptual impairment and show that modulation of this region can rescue the deficit, establishing it as a novel therapeutic target for long COVID cognitive impairment.

q-bio.NC