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Rena Elkin

Publications and source records attributed to Rena Elkin.

5 recordsLinked to original sources

Optimal Transport for Kernel Gaussian Mixture Models

The Wasserstein distance from optimal mass transport (OMT) is a powerful mathematical tool with numerous applications that provides a natural measure of the distance between two probability distributions. Several methods to incorporate OMT into widely used probabilistic models, such as Gaussian or Gaussian mixture, have been developed to enhance the capability of modeling complex multimodal densities of real datasets. However, very few studies have explored the OMT problems in a reproducing kernel Hilbert space (RKHS), wherein the kernel trick is utilized to avoid the need to explicitly map input data into a high-dimensional feature space. In the current study, we propose a Wasserstein-type metric to compute the distance between two Gaussian mixtures in a RKHS via the kernel trick, i.e., kernel Gaussian mixture models.

cs.LG

Visualizing fluid flows via regularized optimal mass transport with applications to neuroscience

Regularized optimal mass transport (rOMT) problem adds a diffusion term to the continuity equation in the original dynamic formulation of the optimal mass transport (OMT) problem proposed by Benamou and Brenier. We show that the rOMT model serves as a powerful tool in computational fluid dynamics (CFD) for visualizing fluid flows in the glymphatic system. In the present work, we describe how to modify the previous numerical method for efficient implementation, resulting in a significant reduction in computational runtime. Numerical results applied to synthetic and real-data are provided.

math.NA

A Vectorial Approach to Unbalanced Optimal Mass Transport

Unbalanced optimal mass transport (OMT) seeks to remove the conservation of mass constraint by adding a source term to the standard continuity equation in the Benamou-Brenier formulation of OMT. In this note, we show how the addition of the source fits into the vector-valued OMT framework.

math.OC

Fisher-Rao Regularized Transport Analysis of the Glymphatic System and Waste Drainage

In this work, a unified representation of all the time-varying dynamics is accomplished with a Lagrangian framework for analyzing Fisher-Rao regularized dynamical optimal mass transport (OMT) derived flows. While formally equivalent to the Eulerian based Schrödinger bridge OMT regularization scheme, the Fisher-Rao approach allows a simple and interpretable methodology for studying the flows of interest in the present work. The advantage of the proposed Lagrangian technique is that the time-varying particle trajectories and attributes are displayed in a single visualization. This provides a natural capability to identify and distinguish flows under different conditions. The Lagrangian analysis applied to the glymphatic system (brain waste removal pathway associated with Alzheimer's Disease) successfully captures known flows and distinguishes between flow patterns under two different anesthetics, providing deeper insights into altered states of waste drainage.

physics.flu-dyn

GlymphVIS: Visualizing Glymphatic Transport Pathways Using Regularized Optimal Transport

The glymphatic system (GS) is a transit passage that facilitates brain metabolic waste removal and its dysfunction has been associated with neurodegenerative diseases such as Alzheimer's disease. The GS has been studied by acquiring temporal contrast enhanced magnetic resonance imaging (MRI) sequences of a rodent brain, and tracking the cerebrospinal fluid injected contrast agent as it flows through the GS. We present here a novel visualization framework, GlymphVIS, which uses regularized optimal transport (OT) to study the flow behavior between time points at which the images are taken. Using this regularized OT approach, we can incorporate diffusion, handle noise, and accurately capture and visualize the time varying dynamics in GS transport. Moreover, we are able to reduce the registration mean-squared and infinity-norm error across time points by up to a factor of 5 as compared to the current state-of-the-art method. Our visualization pipeline yields flow patterns that align well with experts' current findings of the glymphatic system.

cs.CV