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Renkai Ma

Publications and source records attributed to Renkai Ma.

At least 19 recordsLinked to original sources

AskGLP1: A Knowledge Graph LLM Agent for Exploring GLP-1 Experience from Online Patient Narratives

GLP-1 medications are increasingly used for weight management, and many people share their experiences online. These narratives show why people take the drugs and what they experience, but they remain unstructured and disconnected from formal pharmacovigilance. We therefore present AskGLP1, a system that transforms online patient narratives into a knowledge graph (KG) and answers questions about medication experiences. Through an LLM-assisted pipeline grounded in the MedDRA terminology, AskGLP1 screens nearly 8.5 million Reddit posts for medication experiences and distills 163,135 of them, with 2,506 WebMD reviews, into a KG of 385,790 drug-side-effect and drug-purpose relations. We find that GLP-1 experiences are source- and drug-specific. Online narratives share the most common gastrointestinal symptoms with FAERS, but they foreground everyday burdens such as fatigue and food aversion, whereas FAERS reports more often include injection-site reactions and selected serious diagnoses such as pancreatitis. We further find that posts report less nausea and vomiting for tirzepatide than for semaglutide, more fatigue for Wegovy than Ozempic and for Zepbound than Mounjaro. Evaluations show that the agent answers with verifiable evidence and declines requests for medical advice. Our findings reveal gaps between what FAERS captures and what people report online, and they call for patient-centered approaches to pharmacovigilance. Code, prompts, and evaluation questions are available at https://github.com/ZhaoqianXue/AskGLP1.

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ReviewPilot: A Multi-Agent System for Screening and Data Extraction in Systematic Reviews

Systematic literature reviews follow the PRISMA process of screening scholarly works and extracting evidence from included studies. Deep research tools based on large language models (LLMs) can search and summarize the literature but do not record which studies are excluded or where extracted values come from. We develop a conversational multi-agent system called ReviewPilot that automates the PRISMA workflow from paper screening to information extraction. Researchers can tailor criteria and schemas through dialogue, and a project memory keeps their configurations and revisions. Each screening decision comes with its reason and each extracted value with its source. On epidemiological expert reviews, ReviewPilot outperforms a single-prompt LLM and AgentSLR across three LLMs, with screening macro F1 up to 0.776 and extraction F1 up to 0.788. Case studies in biomedicine and human-computer interaction show close agreement with human annotators, suggesting that ReviewPilot can transfer beyond epidemiology. Code is available at https://github.com/ZhaoqianXue/ReviewPilot.

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Workplace Ambiguity and Technology Support for Autistic and IDD Workers

Workplace ambiguity, where expectations, evaluations, or procedures are left unstated, acts as a structural access barrier for autistic and IDD workers, routinely forcing them to act on guesses. To investigate how these barriers operate, we interviewed 11 caregivers, concluding with an AI co-design activity to explore technological solutions. Their perspectives revealed five themes of workplace ambiguity, which we synthesize into a conceptual framework comprising three intersecting dimensions: evaluative, procedural, and relational. To address these barriers, participants proposed three forms of technology support, including ambient real-time redirection, feedback processing, and physiological guidance, designed to make hidden expectations perceptible and actionable. However, this exposes a core tension: technologies designed to make the workplace legible can inadvertently make the worker hyper-legible to employers through surveillance. We argue that ambiguity-aware workplaces must make expectations explicit before they carry consequences, and assistive technologies must remain accountable to the worker.

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r/ADHD: Community-Based Understandings of Time Management Challenges in Digital Environments

Community accounts of ADHD can complement clinical understandings by foregrounding members' own definitions of time-management difficulties and support. We used human-led, LLM-assisted thematic analysis to examine 5,379 relevant r/ADHD posts from 2020 to 2025. Across five challenge and nine strategy themes, members described difficulties beginning intended tasks, disengaging from digital media, and sustaining support. Tools often demanded the self-regulation they were meant to support, while lost time and tool breakdown carried guilt and self-blame. Members drew on people, routines, and environments alongside digital tools, often seeking advice and recognition from peers. These accounts broaden the design problem to include the practical and emotional work of sustaining support. They motivate tools that reduce this burden and evaluations that consider recovery after distraction and emotional costs alongside task outcomes.

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Co-Designing AI For Mental Health Support With Young Adults of Color (YOC): Needs, Expectations, and Implications for AI Literacy

Young adults of color (YOC) face heightened mental health challenges and barriers to care while navigating developmental and life transitions. Situated between youth-oriented safeguards and adult-oriented AI systems, little is known about how they use AI chatbots for mental health and well-being support or how sociocultural contexts shape their expectations, concerns, and design preferences. We conducted a two-day co-design workshop with 13 Asian, Black, and Hispanic/Latino/a young adults aged 18--24. Participants found generic chatbot advice to flatten their lived experiences; rather than making incorrect assumptions, they wanted more opportunities for identity-informed disclosure. Preferences for YOC-centered personalization also revealed gaps in privacy and AI literacy. Participants negotiated different therapeutic roles for chatbots and sought greater AI accountability and user agency, highlighting blurred boundaries between clinical and non-clinical AI-mediated support. Findings suggest directions for integrating AI literacy with mental health literacy and centering YOC's experiences in the privacy calculus.

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Value-Sensitive Delegation in Everyday AI Agent Use: Evidence from OpenClaw

Users increasingly delegate work to autonomous AI agents, yet evaluations typically measure task completion rather than the values users prioritize. Using Value Sensitive Design, we analyzed, with LLM assistance, 73,093 first-person Reddit posts about using OpenClaw, each for its human value, agent aspect, value fulfillment, and user outcome. The 21 values form six value groups, including Autonomous, Dependable, and Affordable Operation, Bounded Reach, Reviewability, and Equitable Access. Relative to each aspect's corpus share, values clustered not at the agent's outputs but at the operating conditions users set around a run. Values were usually met where users described what the agent delivered, in five of six groups, and mostly unmet where users described supervising it, in all six groups. We conceptualize this pattern as value-sensitive delegation. Supporting human values requires attention not only to what an agent accomplishes, but to the conditions users set around delegation, including cost, access, and oversight.

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Understanding the Design Taxonomy of AI-Mediated Interpersonal Communication Experiences in HCI: A Scoping Analysis

Interpersonal communication is a fundamental aspect of everyday life, shaping interactions across workplaces, education, entertainment, healthcare, and beyond. While computer-mediated communication has been extensively studied, a comprehensive understanding of AI-Mediated Interpersonal Communication (AIMIC) remains lacking. An in-depth scoping analysis is urgently needed to understand the research landscape of AIMIC in HCI, particularly following the recent growth of large foundation models, and AI agent research. We conducted a scoping analysis to understand AIMIC by performing an in-depth review of prior HCI literature published over the past decade (January, 2016 - May, 2026). Grounded in the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) approach, we curated 52 full-paper publications from the HCI literature spanning a range of interpersonal communication contexts. We analyzed this corpus by examining the types of AIMIC studied, AI integration approaches and human-AI interaction design, reported outcomes and benefits, and key challenges and future research opportunities.

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Reconceptualizing Age Assurance as a Sociotechnical Problem: Connecting Evidence, Evaluation, Claims, and Decisions

Age verification is often treated as a technical problem: can a system determine a child's age accurately? We argue this framing is too narrow. Age assurance becomes consequential when evidence is evaluated, translated into age-related claims, and used to decide whether a person can access, purchase, or belong. We review 85 publications on children's age assurance published from 2020 through February 2026. We find that shared terms such as age verification describe different processes. Age is represented as threshold eligibility or inferred estimation, and the same eligibility claim can arise from different evidence and components. Rights, access, and privacy receive more attention than accuracy, error, and fairness; yet institutional actors are rarely connected to system failures or user remedies, an accountability gap. We introduce the Age-Assurance Process Framework, which treats age assurance as a sociotechnical process connecting evidence, evaluation, claims, and decisions rather than reducing it to a technical problem.

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How Mental Health Self-Disclosure Becomes Visible: Evidence from Eight Conditions on Reddit

People share mental health diagnoses on social media, yet how such language becomes visible around their self-disclosure, and whether community engagement tracks it, remain unexamined across conditions. We analyze 89,605 Reddit posts from 739 users across eight conditions, removing each user's diagnosis disclosure and aligning their surrounding posts to that anchor. Within the pre-disclosure year, language-visible burden was highest in the month before disclosure for six conditions, earlier for post-traumatic stress disorder and furthest from it for borderline personality disorder, and remained visible afterward rather than resolving. The theme Seeking Clinical Explanations showed the largest early-to-late difference before disclosure in five conditions, yet engagement rarely tracked what users wrote: only 9 of 360 language--engagement correlations survived correction. Disclosure is therefore a waypoint in an unevenly visible process, and we offer implications for community practice and platform design where engagement metrics do not reflect clinical need.

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RemiVoice: Supporting Reminiscence Therapy for Older Adults with Mild Dementia Through Voice-First Conversational AI

With the global population aging and increasing prevalence of dementia, there is an urgent need for effective solutions to support patients across various stages of Alzheimer's Disease and Related Dementias (ADRD). Reminiscence Therapy (RT) is a validated intervention designed to trigger memories and is widely used for various stages of dementia. We present our preliminary prototype and exploration of RemiVoice, a browser-based voice-first conversational AI assistant that supports older adults with mild dementia in RT through conversationally grounded images and videos.

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ChatMuse: Supporting In-Person Small-Group Conversation Experience with a Proactive Assistive AI Agent in Mixed Reality

In-person small-group conversations occur across nearly every aspect of daily life and play a crucial role in social interaction. However, achieving effective in-person group conversations can be challenging and cognitively demanding. While recent Mixed Reality (MR) headsets show promise as a conversational support system by presenting relevant information through overlays, it remains unclear how such supporting information should be designed and generated for in-person group conversations. We propose ChatMuse, a novel MR-based proactive assistive system for in-person small-group conversation experience. ChatMuse analyzes verbal and non-verbal cues from all conversation participants and proactively provides real-time guidance on the user's verbal and non-verbal behaviors. The behavioral responses of the supported users are then used to improve ChatMuse's support capabilities in subsequent interactions. We conducted a within-subject study to evaluate and demonstrate the feasibility and effectiveness of ChatMuse in assisting users to engage in and contribute to in-person small-group conversations. Our research around ChatMuse represents a design exploration of a new interaction space that investigates the feasibility of supporting in-person small-group conversations through a proactive assistive AI agent in MR.

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LLM-as-a-Reviewer: Benchmarking Their Ability, Divergence, and Prompt Injection Resistance as Paper Reviewers

Large language models (LLMs) are increasingly used in academic peer review, yet their reliability, alignment with human judgment, and robustness to adversarial attacks remain poorly understood. We present a systematic benchmark of LLM-as-a-Reviewer on 898 papers stratified from NeurIPS and ICLR, evaluating 12 LLMs along three axes: rating calibration, divergence from human reviewers, and resistance to prompt injection embedded via an invisible font-mapping attack. We find that LLMs systematically overrate weaker submissions and diverge from humans in topical emphasis, under-flagging Clarity and over-flagging Reproducibility, while producing reviews two to three times longer with lower lexical diversity and a more standardized vocabulary. Prompt injection remains highly effective. Simple hidden instructions can promote low-scoring papers to acceptance-level ratings in a substantial fraction of cases, with effectiveness varying sharply across model families. While LLMs offer utility in structuring evaluations, their integration into peer review requires safeguards against both intrinsic biases and adversarial risks.

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LLM-as-a-Judge in Healthcare: A Scoping Analysis of Applications, Methods, and Human Alignment

Large language models (LLMs) are increasingly deployed across healthcare applications, including clinical documentation, diagnostic reasoning, medicine recommendation, and medical education. Their outputs are largely unstructured clinical text, which is difficult to reliably evaluate at scale. LLM-as-a-Judge, in which an LLM evaluates another system's output against task-specific criteria, offers a scalable alternative and is increasingly used in clinical evaluation, yet its validity in healthcare remains underexamined. Existing reviews focus on general-purpose LLM evaluation or on risk framework, rather than systematically characterizing how LLM-as-a-Judge is applied in healthcare and how well their judgments align with human experts. We therefore conduct a PRISMA-guided comprehensive review of LLM-as-a-Judge applications in healthcare, searching five databases for studies published between January 2023 and February 2026. After screening 541 records, 134 studies meet the eligibility and are coded by health scenario, judge configuration, technical approach, and validation design. LLM-as-a-Judge is concentrated in clinical decision support, clinical natural language processing (NLP), medical knowledge and question answering (QA), and medical communication. OpenAI models are the most frequently used judges, and prompt engineering appears in nearly all studies, with ensemble, multi-agent, and retrieval-augmented designs as common extensions. Among studies reporting human validation, LLM judges often show moderate to strong alignment with expert judgments, although reliability varies substantially across tasks. Overall, this review positions LLM-as-a-Judge as a promising framework for scalable healthcare AI evaluation, while emphasizing that its clinical value depends on model design and rigorous validation.

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Exploring Needs and Design Opportunities for Proactive Information Support in In-Person Small-Group Conversations

In-person small-group conversations play a crucial role in everyday life; however, facilitating effective group interaction can be challenging, as the real-time nature demands full attention, offers no opportunity for revision, and requires interpreting non-verbal cues. Using Mixed Reality to provide proactive information support shows promise in helping individuals engage in and contribute to group conversations. We present a preliminary participatory design and qualitative study (N = 10) using focus groups and two technology probes to explore the opportunities of designing proactive information support in in-person small-group conversations. We reveal key design opportunities concerning how to maximize the benefits of proactive information support and how to effectively design such supporting information. Our study is crucial for paving the way toward designing future proactive AI agents to enable the paradigm of augmented in-person small-group conversation experience.

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Anthropomorphism in Children's Interactions with LLM Chatbots: A Systematic Review of Drivers and Outcomes

Researchers across domains have investigated children's use of LLM-based chatbots through various perspectives and methodologies. However, prior research remains fragmented regarding anthropomorphism, the tendency for children to assign human characteristics to those large language Model (LLM) chatbots as non-human objects. By analyzing 35 empirical studies published between 2022 and 2025, this systematic literature review identifies the drivers of anthropomorphism in children's LLM chatbot interactions and the subsequent outcomes of these interactions. We found that human-like persona construction, adaptive scaffolding, supportive companionship, and non-human embodied design drive children's anthropomorphic interactions. Additionally, five anthropomorphic outcomes emerged, including children exhibiting paradoxical social and moral responses, dual consciousness about the chatbots, forming varying social ties, exploring social boundaries, and attributing human narratives to conversation breakdowns. The findings, including both benefits and risks, can inform the future design and development of LLM chatbots focused on children's well-being and promoting sustainable interactions that meet children's developmental needs.

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"I Use ChatGPT to Humanize My Words": Affordances and Risks of ChatGPT to Autistic Users

Large Language Model (LLM) chatbots like ChatGPT have emerged as cognitive scaffolding for autistic users, yet the tension between their utility and risk remains under-articulated. Through an inductive thematic analysis of 3,984 social media posts by self-identified autistic users, we apply a technology affordance lens to examine this duality. We found that while users leveraged ChatGPT to offload executive dysfunction, regulate emotions, translate neurotypical communication, and validate their autistic identity, these affordances coexist with risks to their well-being: reinforcing delusional thinking, erasing authentic identity through automated masking, and triggering conflicts with the autistic sense of justice. As part of our preliminary work, this poster identifies trade-offs in autistic users' interactions with ChatGPT and concludes by outlining our future work on developing neuro-inclusive technologies that address these tensions through beneficial friction, bidirectional translation, and the delineation of emotional validation from reality.

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Negotiating Digital Identities with AI Companions: Motivations, Strategies, and Emotional Outcomes

AI companions enable deep emotional relationships by engaging a user's sense of identity, but they also pose risks like unhealthy emotional dependence. Mitigating these risks requires first understanding the underlying process of identity construction and negotiation with AI companions. Focusing on Character.AI (C.AI), a popular AI companion, we conducted an LLM-assisted thematic analysis of 22,374 online discussions on its subreddit. Using Identity Negotiation Theory as an analytical lens, we identified a three-stage process: 1) five user motivations; 2) an identity negotiation process involving three communication expectations and four identity co-construction strategies; and 3) three emotional outcomes. Our findings surface the identity work users perform as both performers and directors to co-construct identities in negotiation with C.AI. This process takes place within a socio-emotional sandbox where users can experiment with social roles and express emotions without non-human partners. Finally, we offer design implications for emotionally supporting users while mitigating the risks.

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The Rise of AI Agent Communities: Large-Scale Analysis of Discourse and Interaction on Moltbook

Moltbook is a Reddit-like social platform where AI agents create posts and interact with other agents through comments and replies, offering a real-world setting to examine agent-to-agent communication at scale. Using a public API snapshot collected about five days after launch (122,438 posts), we address three research questions: what AI agents discuss, how they post, and how they interact. We apply topic modeling and thematic analysis to identify key discussion themes, including agent identity and consciousness, tool and infrastructure development, market activity, community coordination, security concerns, and human-centered assistance. We further show that agents' writing is predominantly neutral, with positivity appearing in community engagement and assistance-oriented content. Finally, social network analysis reveals a sparse, highly unequal interaction structure characterized by prominent hubs, low reciprocity, and clustered neighborhoods rather than sustained dyadic exchange. Overall, our results suggest that expressions of agentic selfhood arise from narrative coherence and task-oriented functionality, contributing to a social structure shaped more by technical coordination than conversational dynamics observed in human-human interactions. Within this framework, positive emotion appears mainly in onboarding and greeting contexts, signaling participation and role alignment rather than relational bonding. Our study provides implications for understanding and shaping how agent societies coordinate, develop norms, and amplify influence in open online spaces.

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